LORZAFONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H17Cl2N3O3.H2O
Molecular Weight	412.267
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.CN(C(=O)CNC(=O)CN)C1=CC=C(Cl)C=C1C(=O)C2=CC=CC=C2Cl

InChI

InChIKey=KZEVFNKHTIQLJK-UHFFFAOYSA-N

InChI=1S/C18H17Cl2N3O3.H2O/c1-23(17(25)10-22-16(24)9-21)15-7-6-11(19)8-13(15)18(26)12-4-2-3-5-14(12)20;/h2-8H,9-10,21H2,1H3,(H,22,24);1H2

HIDE SMILES / InChI

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C18H17Cl2N3O3
Molecular Weight	394.252
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: DOI: 10.1016/0223-5234(91)90024-H | DOI: 10.1135/cccc19892248 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 743, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | Milne, G.W.A. (2018) Drugs: Synonyms and Properties, retrieved from: https://books.google.ru/books?id=xUlaDwAAQBAJ

Lorzafone showed a pharmacological profile similar to that of diazepam. It belongs to the novel class of ring-opened derivatives of 1,4-benzodiazepines. It is useful minor tranquilizer and muscle relaxant.

Originator

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:34:03 GMT 2025` Edited by `admin` on `Mon Mar 31 17:34:03 GMT 2025`
Record UNII	H19UP2X8L2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LORZAFONE

Official Name

English

LY 123508

Preferred Name

English

LORZAFONE [USAN]

Common Name

English

2-(2-AMINOACETAMIDO)-4'-CHLORO-2'-(O-CHLOROBENZOYL)-N-METHYLACETANILIDE MONOHYDRATE

Common Name

English

GLYCINAMIDE, GLYCYL-N-(4-CHLORO-2-(2-CHLOROBENZOYL)PHENYL)-N-METHYL-, MONOHYDRATE

Systematic Name

English

LORZAFONE [JAN]

Common Name

English

LY-123508

Code

English

Code System Code Type Description

ChEMBL

CHEMBL36565