ALEXIDINE

Possibly Marketed Outside US

Details

Stereochemistry	MIXED
Molecular Formula	C26H56N10
Molecular Weight	508.7898
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC

InChI

InChIKey=LFVVNPBBFUSSHL-UHFFFAOYSA-N

InChI=1S/C26H56N10/c1-5-9-15-21(7-3)19-33-25(29)35-23(27)31-17-13-11-12-14-18-32-24(28)36-26(30)34-20-22(8-4)16-10-6-2/h21-22H,5-20H2,1-4H3,(H5,27,29,31,33,35)(H5,28,30,32,34,36)

HIDE SMILES / InChI

Molecular Formula	C26H56N10
Molecular Weight	508.7898
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/?term=16985057 | https://www.ncbi.nlm.nih.gov/pubmed/29308333 | https://www.ncbi.nlm.nih.gov/pubmed/20167843

Alexidine dihydrochloride, an antibacterial compound, which is used during endodontic procedures. It is a dibiguanide ahent and is effective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1). It was noted that PTPMT1 could serve as a pharmacological target in the treatment of type II diabetes. Alexidine dihydrochloride is also an apoptosis-promoting agent possessing the anticancer properties.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Protein-tyrosine phosphatase mitochondrial 1 2 Target ID: CHEMBL2052033 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20167843	Inhibitor 8504		1.08 µM [IC50]

PubMed

Title	Date	PubMed
Extracellular Paracoccidioides brasiliensis phospholipase B involvement in alveolar macrophage interaction.	2010-09-15	20843362
Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents.	2010-07	20116850
Pharmacological targeting of the mitochondrial phosphatase PTPMT1.	2010-05	20167843
Amoebicidal activities of alexidine against 3 pathogenic strains of acanthamoeba.	2009-01	19125040
Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibiotics.	2008-10	18635521
Fusarium keratitis and contact lens wear: facts and speculations.	2008-08	18608899
Effects of multipurpose solutions on corneal epithelial tight junctions.	2008-01	18180685
In the aftermath of the Fusarium keratitis outbreak: What have we learned?	2007-12	19668512
Biocide uptake in contact lenses and loss of fungicidal activity during storage of contact lenses.	2006-12	17099385
Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent.	2006-09	16985057
Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.	2006-07-26	16930453
Cationic antiseptics: diversity of action under a common epithet.	2005	16162221
Contamination levels of in-use disinfectants in a teaching hospital in Lagos, Nigeria.	2002-06	12518903
Lotions and lubricants.	2001-03	12026657

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:23:37 GMT 2025` Edited by `admin` on `Mon Mar 31 18:23:37 GMT 2025`
Record UNII	GVN71CAL3G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BISGUADINE

Preferred Name

English

ALEXIDINE

Official Name

English

ALEXIDINE [MART.]

Common Name

English

WIN-21904

Code

English

alexidine [INN]

Common Name

English

1,1'-HEXAMETHYLENEBIS(5-(2-ETHYLHEXYL)BIGUANIDE)

Systematic Name

English

WIN 21,904

Code

English

STERWIN 904

Code

English

ALEXIDINE [USAN]

Common Name

English

2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE, N,N''-BIS(2-ETHYLHEXYL)-3,12-DIIMINO-

Systematic Name

English

N,N''-BIS(2-ETHYLHEXYL)-3,12-DIIMINO-2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE

Systematic Name

English

COMPOUND 904

Code

English

ALEXIDINE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394