ALEXIDINE

Possibly Marketed Outside US

Details

Stereochemistry	MIXED
Molecular Formula	C26H56N10
Molecular Weight	508.7898
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC

InChI

InChIKey=LFVVNPBBFUSSHL-UHFFFAOYSA-N

InChI=1S/C26H56N10/c1-5-9-15-21(7-3)19-33-25(29)35-23(27)31-17-13-11-12-14-18-32-24(28)36-26(30)34-20-22(8-4)16-10-6-2/h21-22H,5-20H2,1-4H3,(H5,27,29,31,33,35)(H5,28,30,32,34,36)

HIDE SMILES / InChI

Molecular Formula	C26H56N10
Molecular Weight	508.7898
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/?term=16985057 | https://www.ncbi.nlm.nih.gov/pubmed/29308333 | https://www.ncbi.nlm.nih.gov/pubmed/20167843

Alexidine dihydrochloride, an antibacterial compound, which is used during endodontic procedures. It is a dibiguanide ahent and is effective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1). It was noted that PTPMT1 could serve as a pharmacological target in the treatment of type II diabetes. Alexidine dihydrochloride is also an apoptosis-promoting agent possessing the anticancer properties.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Protein-tyrosine phosphatase mitochondrial 1 2 Target ID: CHEMBL2052033 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20167843	Inhibitor 8297		1.08 µM [IC50]

PubMed

Title	Date	PubMed
Lotions and lubricants.	2001 Mar	12026657
Cationic antiseptics: diversity of action under a common epithet.	2005	16162221
Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.	2006 Jul 26	16930453
Effects of multipurpose solutions on corneal epithelial tight junctions.	2008 Jan	18180685
Extracellular Paracoccidioides brasiliensis phospholipase B involvement in alveolar macrophage interaction.	2010 Sep 15	20843362

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:16:18 GMT 2023` Edited by `admin` on `Fri Dec 15 16:16:18 GMT 2023`
Record UNII	GVN71CAL3G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALEXIDINE

Official Name

English

ALEXIDINE [MART.]

Common Name

English

WIN-21904

Code

English

alexidine [INN]

Common Name

English

1,1'-HEXAMETHYLENEBIS(5-(2-ETHYLHEXYL)BIGUANIDE)

Systematic Name

English

WIN 21,904

Code

English

STERWIN 904

Code

English

ALEXIDINE [USAN]

Common Name

English

BISGUADINE

Brand Name

English

2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE, N,N''-BIS(2-ETHYLHEXYL)-3,12-DIIMINO-

Systematic Name

English

N,N''-BIS(2-ETHYLHEXYL)-3,12-DIIMINO-2,4,11,13-TETRAAZATETRADECANEDIIMIDAMIDE

Systematic Name

English

COMPOUND 904

Code

English

ALEXIDINE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394