Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C13H17NO2 |
| Molecular Weight | 219.2796 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(CCCCN1)[C@H](C(O)=O)C2=CC=CC=C2
InChI
InChIKey=INGSNVSERUZOAK-VXGBXAGGSA-N
InChI=1S/C13H17NO2/c15-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-14-11/h1-3,6-7,11-12,14H,4-5,8-9H2,(H,15,16)/t11-,12-/m1/s1
| Molecular Formula | C13H17NO2 |
| Molecular Weight | 219.2796 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Ritalinic acid is an inactive, major metabolite of methylphenidate, a schedule II drug in the United States commonly used as a psychostimulant drugs methylphenidate and ethylphenidate. The elimination half-life of methylphenidate is relatively short (approximately 2 hours); therefore it is also available in extended release (ER) forms. The main metabolite is ritalinic acid, and the methylphenidate metabolites are mostly excreted in urine.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A single-dose, two-way crossover, bioequivalence study of dexmethylphenidate HCl with and without food in healthy subjects. | 2004 Feb |
|
| Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: potential sources of metabolic drug interactions. | 2010 Apr 11 |
|
| Metabolomics of Methylphenidate and Ethylphenidate: Implications in Pharmacological and Toxicological Effects. | 2017 Feb |
|
| Biotransformation of ritalinic acid by laccase in the presence of mediator TEMPO. | 2018 Jul 25 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:48:20 GMT 2023
by
admin
on
Fri Dec 15 15:48:20 GMT 2023
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| Record UNII |
GT4165RS9H
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| Record Status |
Validated (UNII)
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243-020-7
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19395-41-6
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NON-SPECIFIC STEREOCHEMISTRY | |||
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54631-24-2
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SUB122938
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DTXSID20864888
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Ritalinic acid
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GT4165RS9H
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10922012
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100000145107
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| Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
| Related Record | Type | Details | ||
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PARENT -> METABOLITE INACTIVE |
MAJOR
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| Related Record | Type | Details | ||
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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PARENT -> IMPURITY |
Limit is 0.5 at Detector: UV 209 nm
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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