AZD-1134

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H32FN5O4
Molecular Weight	521.5832
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC(=O)N1CCN(CC1)C2=CC=C(NC(=O)C3=CC(=O)C4=CC(F)=CC(N5CCN(C)CC5)=C4O3)C=C2

InChI

InChIKey=CKBARMWSFIJZTL-UHFFFAOYSA-N

InChI=1S/C28H32FN5O4/c1-3-26(36)34-14-12-32(13-15-34)21-6-4-20(5-7-21)30-28(37)25-18-24(35)22-16-19(29)17-23(27(22)38-25)33-10-8-31(2)9-11-33/h4-7,16-18H,3,8-15H2,1-2H3,(H,30,37)

HIDE SMILES / InChI

Molecular Formula	C28H32FN5O4
Molecular Weight	521.5832
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:32:49 GMT 2023` Edited by `admin` on `Sat Dec 16 11:32:49 GMT 2023`
Record UNII	GR7FP8T3TF
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AZD-1134

Code

English

6-FLUORO-8-(4-METHYLPIPERAZIN-1-YL)-4-OXO-4H-CHROMENE-2-CARBOXYLIC ACID (4-(4-PROPIONYLPIPERAZIN-1-YL)PHENYL)AMIDE

Systematic Name

English

ZM-549865

Code

English

4H-1-BENZOPYRAN-2-CARBOXAMIDE, 6-FLUORO-8-(4-METHYL-1-PIPERAZINYL)-4-OXO-N-(4-(4-(1-OXOPROPYL)-1-PIPERAZINYL)PHENYL)-

Systematic Name

English

AZD1134

Code

English

6-FLUORO-8-(4-METHYLPIPERAZIN-1-YL)-4-OXO-N-(4-(4-PROPANOYLPIPERAZIN-1-YL)PHENYL)CHROMENE-2-CARBOXAMIDE

Systematic Name

English

Code System Code Type Description

FDA UNII

GR7FP8T3TF

Created by admin on Sat Dec 16 11:32:49 GMT 2023 , Edited by admin on Sat Dec 16 11:32:49 GMT 2023

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MANUFACTURER PRODUCT INFORMATION

AZD-1134

Created by admin on Sat Dec 16 11:32:49 GMT 2023 , Edited by admin on Sat Dec 16 11:32:49 GMT 2023

PRIMARY

Biological descriptionFluorescent 5-HT1B antagonist (pKD = 6.71). No intrinsic agonist activity in vitro. Wide range of applications which include localizing receptor distribution in tissues and cells, and live-cell imaging of receptor kinetics.

CAS

442548-99-4

Created by admin on Sat Dec 16 11:32:49 GMT 2023 , Edited by admin on Sat Dec 16 11:32:49 GMT 2023

PRIMARY

PUBCHEM

9830790

Created by admin on Sat Dec 16 11:32:49 GMT 2023 , Edited by admin on Sat Dec 16 11:32:49 GMT 2023

PRIMARY

Related Record Type Details


					GR7FP8T3TF

AZD-1134

ACTIVE MOIETY

Comments:

Class: Antidepressant, Anxiolytic: Mechanism of Action: Serotonin 1B receptor antagonist; Highest Development Phase: Discontinued for Anxiety disorders and Major depressive disorder; Most Recent Events: 31 Mar 2004 Discontinued - Preclinical for Depression in USA (unspecified route), 31 Mar 2004 Discontinued - Preclinical for Anxiety disorders in USA (unspecified route)