Debamestrocel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 18:23:57 UTC 2023` Edited by `admin` on `Sat Dec 16 18:23:57 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BONE MARROW
Fraction Name	Multipotent Mesenchymal Stromal Cells
Record UNII	GPC34QP6X6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Debamestrocel

Official Name

English

AUTOLOGOUS MESENCHYMAL STROMAL CELLS SECRETING NEUROTROPHIC FACTORS

Common Name

English

DEBAMESTROCEL [USAN]

Common Name

English

NurOwn

Brand Name

English

AUTOLOGOUS MSC-NTF

Common Name

English

AUTOLOGOUS MESENCHYMAL STROMAL CELLS (MSC) SECRETING NEUROTROPHIC FACTORS (NTF)

Common Name

English

debamestrocel [INN]

Common Name

English

The MSC-NTF cells are Mesenchymal Stem Cells (MSC) secreting Neurotrophic factors. The autologous MSC are isolated from the mononuclear fraction of the patient’s own Bone Marrow (BM), propagated ex-vivo in a xeno-free growth medium and induced to diffe

Common Name

English

Code System Code Type Description

USAN

JK-263

Created by admin on Sat Dec 16 18:23:57 UTC 2023 , Edited by admin on Sat Dec 16 18:23:57 UTC 2023

PRIMARY

NCI_THESAURUS

C190756

Created by admin on Sat Dec 16 18:23:57 UTC 2023 , Edited by admin on Sat Dec 16 18:23:57 UTC 2023

PRIMARY

FDA UNII

GPC34QP6X6

Created by admin on Sat Dec 16 18:23:57 UTC 2023 , Edited by admin on Sat Dec 16 18:23:57 UTC 2023

PRIMARY

INN

12415

Created by admin on Sat Dec 16 18:23:57 UTC 2023 , Edited by admin on Sat Dec 16 18:23:57 UTC 2023

PRIMARY

Related Record Type Details


					GPC34QP6X6

Debamestrocel

ACTIVE MOIETY

Comments:

MSC-NTF cells (NurOwn®) are autologous bone marrow derived mesenchymal stem cells (MSC) induced in culture to secrete high levels of neurotrophic factors (NTFs) that support neuronal growth and survival

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
CULTURE	DIFFERENTIATION AGENT	DIFFERENTIATION		NEUREGULIN-1 BETA1	BD6CJ9UGZ7