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Description
Curator's Comment: The description was created based on several sources, including https://www.drugbank.ca/drugs/DB00046 | https://www.accessdata.fda.gov/drugsatfda_docs/label/1999/21017lbl.pdf

Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Chemically, insulin lispro is Lys(B28), Pro(B29) human insulin analog, created when the amino acids at positions 28 and 29 on the insulin B-chain are reversed. Insulin lispro is synthesized in a special non-pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for insulin lispro. Regulation of glucose metabolism is the primary activity of insulins and insulin analogs, including insulin lispro products. Insulins lower blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulins inhibit lipolysis and proteolysis, and enhance protein synthesis. Insulin lispro begins to exert its effects within 15 minutes of subcutaneous administration, while peak levels occur 30 to 90 minutes after administration. Due to its duration of action of around 5 hours, Humalog is considered "bolus insulin" as it provides high levels of insulin in a short period of time to mimic the release of endogenous insulin from the pancreas after meals. Bolus insulin is often combined with once daily, long-acting "basal insulin" to provide low concentrations of background insulin that can keep blood sugar stable between meals or overnight. Use of basal and bolus insulin together is intended to mimic the pancreas' production of endogenous insulin, with a goal of avoiding any periods of hypoglycemia.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
HUMALOG MIX

Approved Use

Humalog Mix75/25, a mixture of 75% insulin lispro protamine suspension and 25% insulin lispro injection, (rDNA origin), is indicated in the treatment of patients with diabetes mellitus for the control of hyperglycemia. Humalog Mix75/25 has a more rapid onset of glucose-lowering activity compared with Humulin 70/30 while having a similar duration of action. This profile is achieved by combining the rapid onset of Humalog with the intermediate action of insulin lispro protamine suspension.

Launch Date

9.4573442E11
Substance Class Protein
Created
by admin
on Sat Dec 16 01:01:20 UTC 2023
Edited
by admin
on Sat Dec 16 01:01:20 UTC 2023
Protein Type PEPTIDE
Protein Sub Type INSULINS
Sequence Type COMPLETE
Record UNII
GFX7QIS1II
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
INSULIN LISPRO
EMA EPAR   EP   INN   MI   USAN   USP   USP-RS   WHO-DD  
USAN   INN  
Official Name English
IDENTICAL TO HUMAN INSULIN EXCEPT FOR THE TRANSPOSITION OF PROLINE AND LYSINE AT POSITIONS 28 AND 29 ON THE B CHAIN
Common Name English
INSULIN LISPRO (GENETICAL RECOMBINATION)
Common Name English
HUMALOG
Brand Name English
INSULIN LISPRO RECOMBINANT [ORANGE BOOK]
Common Name English
INSULIN LISPRO [EMA EPAR]
Common Name English
LISPRO
Common Name English
insulin lispro [INN]
Common Name English
Insulin lispro protamine suspension [WHO-DD]
Common Name English
LISPRO-PH20 COMPONENT INSULIN LISPRO
Common Name English
INSULIN LISPRO [EP MONOGRAPH]
Common Name English
INSULIN,LISPRO,PROTAMINE/RDNA
VANDF  
Common Name English
INSULIN,LISPRO,PROTAMINE/RDNA [VANDF]
Common Name English
INSULIN LISPRO RECOMBINANT
ORANGE BOOK  
Common Name English
LY900014
Code English
LISPRO INSULIN
Common Name English
ADMELOG
Brand Name English
INSULIN LISPRO (RDNA ORIGIN)
Common Name English
INSULIN B28(LYS)-B29(PRO) RECOMBINANT HUMAN/PROTAMINE SULPHATE
Common Name English
INSULIN LISPRO [USP MONOGRAPH]
Common Name English
28(SUP B)-L-LYSINE-29(SUP B)-L-PROLINEINSULIN (HUMAN)
Common Name English
INSULIN LISPRO PROTAMINE
Common Name English
INSULIN LISPRO [USAN]
Common Name English
INSULIN LISPRO [MI]
Common Name English
INSULIN,LISPRO,HUMAN/RDNA [VANDF]
Common Name English
ADMELOG SOLOSTAR
Brand Name English
INSULIN LISPRO PROTAMINE RECOMBINANT [ORANGE BOOK]
Common Name English
LY-275585
Code English
INSULIN LISPRO PROTAMINE SUSPENSION
WHO-DD  
Common Name English
Insulin lispro [WHO-DD]
Common Name English
SAR-342434
Code English
INSULIN LISPRO [USP-RS]
Common Name English
LY275585
Code English
INSULIN LISPRO [JAN]
Common Name English
SAR342434
Code English
INSULIN,LISPRO,HUMAN/RDNA
VANDF  
Common Name English
INSULIN (HUMAN), 28(SUP B)-L-LYSINE-29(SUP B)-L-PROLINE-
Common Name English
INSULIN LISPRO PROTAMINE RECOMBINANT
ORANGE BOOK  
Common Name English
LY-900014
Code English
Classification Tree Code System Code
NDF-RT N0000175453
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
NCI_THESAURUS C581
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
NDF-RT N0000004931
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
WHO-ATC A10AB04
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
WHO-VATC QA10AC04
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
WHO-VATC QA10AD04
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
NDF-RT N0000004931
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
WHO-VATC QA10AB04
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
WHO-ATC A10AD04
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
WHO-ATC A10AC04
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
NDF-RT N0000004931
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
Code System Code Type Description
FDA UNII
GFX7QIS1II
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
EVMPD
SUB128662
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
ChEMBL
CHEMBL1201611
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
DAILYMED
GFX7QIS1II
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
RXCUI
86009
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY RxNorm
MERCK INDEX
m6300
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY Merck Index
NCI_THESAURUS
C29123
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
PUBCHEM
118984450
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
EVMPD
SUB08198MIG
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
EPA CompTox
DTXSID90157956
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
DRUG CENTRAL
5002
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
MESH
D061268
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
DRUG BANK
DB00046
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
CAS
133107-64-9
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
EVMPD
SUB128661
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
RS_ITEM_NUM
1342321
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
WIKIPEDIA
INSULIN LISPRO
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
USAN
EE-77
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
INN
7278
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
SMS_ID
100000090248
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
ChEMBL
CHEMBL1201538
Created by admin on Sat Dec 16 01:01:20 UTC 2023 , Edited by admin on Sat Dec 16 01:01:20 UTC 2023
PRIMARY
From To
1_7 2_7
1_19 2_20
2_6 2_11
Related Record Type Details
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:SEQUENCE CHEMICAL
Molecular Formula CHEMICAL