FAUC-213

ClC1=CC=C(C=C1)N2CCN(CC3=NN4C=CC=CC4=C3)CC2

InChIKey=DTRXURJDKOYCCD-UHFFFAOYSA-N

InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)14-16-13-18-3-1-2-8-23(18)20-16/h1-8,13H,9-12,14H2

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).	2001 Aug 16	11495580
Attenuation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity by the novel selective dopamine D3-receptor partial agonist FAUC 329 predominantly in the nucleus accumbens of mice.	2003 Sep 15	12963489
FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia.	2004 Aug	15007532
Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain.	2004 Dec	15448188
Reciprocal mutations in TM2/TM3 in a D2 dopamine receptor background confirms the importance of this microdomain as a selective determinant of para-halogenated 1,4-disubstituted aromatic piperazines.	2005 Jun	15952239

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:03:07 UTC 2023` Edited by `admin` on `Sat Dec 16 10:03:07 UTC 2023`
Record UNII	G8F040299R
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

FAUC-213

Common Name

English

PYRAZOLO(1,5-A)PYRIDINE, 2-((4-(4-CHLOROPHENYL)-1-PIPERAZINYL)METHYL)-

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID40187460

Created by admin on Sat Dec 16 10:03:07 UTC 2023 , Edited by admin on Sat Dec 16 10:03:07 UTC 2023

PRIMARY

CAS

337972-47-1

Created by admin on Sat Dec 16 10:03:07 UTC 2023 , Edited by admin on Sat Dec 16 10:03:07 UTC 2023

PRIMARY

PUBCHEM

10336538

Created by admin on Sat Dec 16 10:03:07 UTC 2023 , Edited by admin on Sat Dec 16 10:03:07 UTC 2023

PRIMARY

FDA UNII

G8F040299R

Created by admin on Sat Dec 16 10:03:07 UTC 2023 , Edited by admin on Sat Dec 16 10:03:07 UTC 2023

PRIMARY

Related Record Type Details


					G8F040299R

FAUC-213

ACTIVE MOIETY