Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H10Cl2F3N3O3 |
| Molecular Weight | 432.181 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C2N=C(C=CC2=C(C=C1)C(=O)NC3=C(Cl)C=[N+]([O-])C=C3Cl)C(F)(F)F
InChI
InChIKey=RUOGJYKOQBFJIG-UHFFFAOYSA-N
InChI=1S/C17H10Cl2F3N3O3/c1-28-12-4-2-9(8-3-5-13(17(20,21)22)23-14(8)12)16(26)24-15-10(18)6-25(27)7-11(15)19/h2-7H,1H3,(H,24,26)
| Molecular Formula | C17H10Cl2F3N3O3 |
| Molecular Weight | 432.181 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 17:24:12 GMT 2025
by
admin
on
Tue Apr 01 17:24:12 GMT 2025
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| Record UNII |
G6EF7V146S
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| Record Status |
Validated (UNII)
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| Record Version |
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Preferred Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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G6EF7V146S
Created by
admin on Tue Apr 01 17:24:12 GMT 2025 , Edited by admin on Tue Apr 01 17:24:12 GMT 2025
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444659-43-2
Created by
admin on Tue Apr 01 17:24:12 GMT 2025 , Edited by admin on Tue Apr 01 17:24:12 GMT 2025
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266995-28-2
Created by
admin on Tue Apr 01 17:24:12 GMT 2025 , Edited by admin on Tue Apr 01 17:24:12 GMT 2025
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9802841
Created by
admin on Tue Apr 01 17:24:12 GMT 2025 , Edited by admin on Tue Apr 01 17:24:12 GMT 2025
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SCH-351591
Created by
admin on Tue Apr 01 17:24:12 GMT 2025 , Edited by admin on Tue Apr 01 17:24:12 GMT 2025
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PRIMARY | Chemical Name: D4396; N-(3,5-Dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinolinecarboxamide | ||
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77774
Created by
admin on Tue Apr 01 17:24:12 GMT 2025 , Edited by admin on Tue Apr 01 17:24:12 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
An EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor that specifically blocks the action of phosphodiesterase IV.
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ACTIVE MOIETY |
N-(3,5-Dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591) has been identified as a potent (IC(50) = 58 nM) and highly selective type 4 phosphodiesterase (PDE4) inhibitor with oral bioactivity in several animal models of lung inflammation.
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