SCH-351591

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H10Cl2F3N3O3
Molecular Weight	432.181
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

COC1=C2N=C(C=CC2=C(C=C1)C(=O)NC3=C(Cl)C=[N+]([O-])C=C3Cl)C(F)(F)F

InChI

InChIKey=RUOGJYKOQBFJIG-UHFFFAOYSA-N

InChI=1S/C17H10Cl2F3N3O3/c1-28-12-4-2-9(8-3-5-13(17(20,21)22)23-14(8)12)16(26)24-15-10(18)6-25(27)7-11(15)19/h2-7H,1H3,(H,24,26)

HIDE SMILES / InChI

Molecular Formula	C17H10Cl2F3N3O3
Molecular Weight	432.181
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical
Record UNII	G6EF7V146S
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

D-4396

Preferred Name

English

SCH-351591

Common Name

English

N-(3,5-DICHLORO-1-OXO-4-PYRIDYL)-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE-5-CARBOXAMIDE

Systematic Name

English

5-QUINOLINECARBOXAMIDE, N-(3,5-DICHLORO-1-OXIDO-4-PYRIDINYL)-8-METHOXY-2-(TRIFLUOROMETHYL)-

Systematic Name

English

Showing 1 to 4 of 4 entries

Previous1Next

Show entries

Code System

Code

Type

Description

FDA UNII

G6EF7V146S

PRIMARY

CAS

444659-43-2

PRIMARY

CAS

266995-28-2

SUPERSEDED

PUBCHEM

9802841

PRIMARY

MANUFACTURER PRODUCT INFORMATION

SCH-351591

PRIMARY

Chemical Name: D4396; N-(3,5-Dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinolinecarboxamide

Showing 1 to 5 of 6 entries

Previous1 2Next

Show entries

Related Record

Type

Details


					G6EF7V146S

SCH-351591

ACTIVE MOIETY

Comments:

An EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor that specifically blocks the action of phosphodiesterase IV.


					G6EF7V146S

SCH-351591

ACTIVE MOIETY

Comments:

N-(3,5-Dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591) has been identified as a potent (IC(50) = 58 nM) and highly selective type 4 phosphodiesterase (PDE4) inhibitor with oral bioactivity in several animal models of lung inflammation.

Showing 1 to 2 of 2 entries

Previous1Next