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Details

Stereochemistry ACHIRAL
Molecular Formula 2C17H18FN3O3.2ClH.3H2O
Molecular Weight 789.651
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CIPROFLOXACIN HYDROCHLORIDE SESQUIHYDRATE

SMILES

O.O.O.Cl.Cl.OC(=O)C1=CN(C2CC2)C3=C(C=C(F)C(=C3)N4CCNCC4)C1=O.OC(=O)C5=CN(C6CC6)C7=C(C=C(F)C(=C7)N8CCNCC8)C5=O

InChI

InChIKey=SMFVXHJJUFAKBS-UHFFFAOYSA-N
InChI=1S/2C17H18FN3O3.2ClH.3H2O/c2*18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;;;;;/h2*7-10,19H,1-6H2,(H,23,24);2*1H;3*1H2

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C17H18FN3O3
Molecular Weight 331.3415
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/ciprofloxacin.html | https://clinicaltrials.gov/ct2/show/NCT02598362 | https://www.ncbi.nlm.nih.gov/pubmed/25951434

Ciprofloxacin (1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid) is the synthetic antimicrobial agent for oral or intravenous administration. Ciprofloxacin is a member of the fluoroquinolone class of antibacterial agents. The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV (both Type II topoisomerases), which are required for bacterial DNA replication, transcription, repair, and recombination. Ciprofloxacin is used to treat a wide variety of infections, including infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, and chancroid. In the United States, ciprofloxacin is pregnancy category C. This category includes drugs for which no adequate and well-controlled studies in human pregnancy exist, and for which animal studies have suggested the potential for harm to the fetus, but potential benefits may warrant use of the drug in pregnant women despite potential risks. Fluoroquinolones have been reported as present in a mother's milk and thus passed on to the nursing child. Oral and intravenous ciprofloxacin is approved by the FDA for use in children for only two indications due to the risk of permanent injury to the musculoskeletal system: Inhalational anthrax (postexposure) and Complicated urinary tract infections and pyelonephritis due to Escherichia coli.

Originator

Sources: Proc. Int. Congr. Chemother., 13th (1983), 5, 112/1-112/4.
Curator's Comment: # Bayer

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
150.0 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
CIPRO

Approved Use

Ciprofloxacin Tablets, USP are indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions and patient populations listed below. Please see DOSAGE AND ADMINISTRATION for specific recommendations. Adult Patients Urinary Tract Infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus mirabilis, Providencia rettgeri, Morganella morganii, Citrobacter diversus, Citrobacter freundii, Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus epidermidis, Staphylococcus saprophyticus, or Enterococcus faecalis. Acute Uncomplicated Cystitis in females caused by Escherichia coli or Staphylococcus saprophyticus. Chronic Bacterial Prostatitis caused by Escherichia coli or Proteus mirabilis. Lower Respiratory Tract Infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus influenzae, Haemophilus parainfluenzae, or penicillin-susceptible Streptococcus pneumoniae. Also, Moraxella catarrhalis for the treatment of acute exacerbations of chronic bronchitis. NOTE: Although effective in clinical trials, ciprofloxacin is not a drug of first choice in the treatment of presumed or confirmed pneumonia secondary to Streptococcus pneumoniae. Acute Sinusitis caused by Haemophilus influenzae, penicillin-susceptible Streptococcus pneumoniae, or Moraxella catarrhalis. Skin and Skin Structure Infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Proteus vulgaris, Providencia stuartii, Morganella morganii, Citrobacter freundii, Pseudomonas aeruginosa, methicillin susceptible Staphylococcus aureus, methicillin susceptible Staphylococcus epidermidis, or Streptococcus pyogenes. Bone and Joint Infections caused by Enterobacter cloacae, Serratia marcescens, or Pseudomonas aeruginosa. Complicated Intra-Abdominal Infections (used in combination with metronidazole) caused by Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, or Bacteroides fragilis. Infectious Diarrhea caused by Escherichia coli (enterotoxigenic strains), Campylobacter jejuni, Shigella boydii † , Shigella dysenteriae, Shigella flexneri or Shigella sonnei † when antibacterial therapy is indicated. Typhoid Fever (Enteric Fever) caused by Salmonella typhi. NOTE: The efficacy of ciprofloxacin in the eradication of the chronic typhoid carrier state has not been demonstrated. Uncomplicated cervical and urethral gonorrhea due to Neisseria gonorrhoeae. Pediatric patients (1 to 17 years of age)Complicated Urinary Tract Infections and Pyelonephritis due to Escherichia coli. NOTE: Although effective in clinical trials, ciprofloxacin is not a drug of first choice in the pediatric population due to an increased incidence of adverse events compared to controls, including events related to joints and/or surrounding tissues. (See WARNINGS, PRECAUTIONS, Pediatric Use , ADVERSE REACTIONS and CLINICAL STUDIES .) Ciprofloxacin, like other fluoroquinolones, is associated with arthropathy and histopathological changes in weight-bearing joints of juvenile animals. (See ANIMAL PHARMACOLOGY .) Adult and Pediatric PatientsInhalational anthrax (post-exposure): To reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis. Ciprofloxacin serum concentrations achieved in humans served as a surrogate endpoint reasonably likely to predict clinical benefit and provided the initial basis for approval of this indication.5 Supportive clinical information for ciprofloxacin for anthrax post-exposure prophylaxis was obtained during the anthrax bioterror attacks of October 2001. (See also, INHALATIONAL ANTHRAX – ADDITIONAL INFORMATION ). †Although treatment of infections due to this organism in this organ system demonstrated a clinically significant outcome, efficacy was studied in fewer than 10 patients. If anaerobic organisms are suspected of contributing to the infection, appropriate therapy should be administered. Appropriate culture and susceptibility tests should be performed before treatment in order to isolate and identify organisms causing infection and to determine their susceptibility to ciprofloxacin. Therapy with Ciprofloxacin Tablets may be initiated before results of these tests are known; once results become available appropriate therapy should be continued. As with other drugs, some strains of Pseudomonas aeruginosa may develop resistance fairly rapidly during treatment with ciprofloxacin. Culture and susceptibility testing performed periodically during therapy will provide information not only on the therapeutic effect of the antimicrobial agent but also on the possible emergence of bacterial resistance. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ciprofloxacin Tablets and other antibacterial drugs, Ciprofloxacin Tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Launch Date

1990
Curative
CIPRO

Approved Use

Ciprofloxacin Tablets, USP are indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions and patient populations listed below. Please see DOSAGE AND ADMINISTRATION for specific recommendations. Adult Patients Urinary Tract Infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus mirabilis, Providencia rettgeri, Morganella morganii, Citrobacter diversus, Citrobacter freundii, Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus epidermidis, Staphylococcus saprophyticus, or Enterococcus faecalis. Acute Uncomplicated Cystitis in females caused by Escherichia coli or Staphylococcus saprophyticus. Chronic Bacterial Prostatitis caused by Escherichia coli or Proteus mirabilis. Lower Respiratory Tract Infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus influenzae, Haemophilus parainfluenzae, or penicillin-susceptible Streptococcus pneumoniae. Also, Moraxella catarrhalis for the treatment of acute exacerbations of chronic bronchitis. NOTE: Although effective in clinical trials, ciprofloxacin is not a drug of first choice in the treatment of presumed or confirmed pneumonia secondary to Streptococcus pneumoniae. Acute Sinusitis caused by Haemophilus influenzae, penicillin-susceptible Streptococcus pneumoniae, or Moraxella catarrhalis. Skin and Skin Structure Infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Proteus vulgaris, Providencia stuartii, Morganella morganii, Citrobacter freundii, Pseudomonas aeruginosa, methicillin susceptible Staphylococcus aureus, methicillin susceptible Staphylococcus epidermidis, or Streptococcus pyogenes. Bone and Joint Infections caused by Enterobacter cloacae, Serratia marcescens, or Pseudomonas aeruginosa. Complicated Intra-Abdominal Infections (used in combination with metronidazole) caused by Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, or Bacteroides fragilis. Infectious Diarrhea caused by Escherichia coli (enterotoxigenic strains), Campylobacter jejuni, Shigella boydii † , Shigella dysenteriae, Shigella flexneri or Shigella sonnei † when antibacterial therapy is indicated. Typhoid Fever (Enteric Fever) caused by Salmonella typhi. NOTE: The efficacy of ciprofloxacin in the eradication of the chronic typhoid carrier state has not been demonstrated. Uncomplicated cervical and urethral gonorrhea due to Neisseria gonorrhoeae. Pediatric patients (1 to 17 years of age)Complicated Urinary Tract Infections and Pyelonephritis due to Escherichia coli. NOTE: Although effective in clinical trials, ciprofloxacin is not a drug of first choice in the pediatric population due to an increased incidence of adverse events compared to controls, including events related to joints and/or surrounding tissues. (See WARNINGS, PRECAUTIONS, Pediatric Use , ADVERSE REACTIONS and CLINICAL STUDIES .) Ciprofloxacin, like other fluoroquinolones, is associated with arthropathy and histopathological changes in weight-bearing joints of juvenile animals. (See ANIMAL PHARMACOLOGY .) Adult and Pediatric PatientsInhalational anthrax (post-exposure): To reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis. Ciprofloxacin serum concentrations achieved in humans served as a surrogate endpoint reasonably likely to predict clinical benefit and provided the initial basis for approval of this indication.5 Supportive clinical information for ciprofloxacin for anthrax post-exposure prophylaxis was obtained during the anthrax bioterror attacks of October 2001. (See also, INHALATIONAL ANTHRAX – ADDITIONAL INFORMATION ). †Although treatment of infections due to this organism in this organ system demonstrated a clinically significant outcome, efficacy was studied in fewer than 10 patients. If anaerobic organisms are suspected of contributing to the infection, appropriate therapy should be administered. Appropriate culture and susceptibility tests should be performed before treatment in order to isolate and identify organisms causing infection and to determine their susceptibility to ciprofloxacin. Therapy with Ciprofloxacin Tablets may be initiated before results of these tests are known; once results become available appropriate therapy should be continued. As with other drugs, some strains of Pseudomonas aeruginosa may develop resistance fairly rapidly during treatment with ciprofloxacin. Culture and susceptibility testing performed periodically during therapy will provide information not only on the therapeutic effect of the antimicrobial agent but also on the possible emergence of bacterial resistance. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ciprofloxacin Tablets and other antibacterial drugs, Ciprofloxacin Tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Launch Date

1990
Curative
CIPRO

Approved Use

Ciprofloxacin Tablets, USP are indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions and patient populations listed below. Please see DOSAGE AND ADMINISTRATION for specific recommendations. Adult Patients Urinary Tract Infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus mirabilis, Providencia rettgeri, Morganella morganii, Citrobacter diversus, Citrobacter freundii, Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus epidermidis, Staphylococcus saprophyticus, or Enterococcus faecalis. Acute Uncomplicated Cystitis in females caused by Escherichia coli or Staphylococcus saprophyticus. Chronic Bacterial Prostatitis caused by Escherichia coli or Proteus mirabilis. Lower Respiratory Tract Infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus influenzae, Haemophilus parainfluenzae, or penicillin-susceptible Streptococcus pneumoniae. Also, Moraxella catarrhalis for the treatment of acute exacerbations of chronic bronchitis. NOTE: Although effective in clinical trials, ciprofloxacin is not a drug of first choice in the treatment of presumed or confirmed pneumonia secondary to Streptococcus pneumoniae. Acute Sinusitis caused by Haemophilus influenzae, penicillin-susceptible Streptococcus pneumoniae, or Moraxella catarrhalis. Skin and Skin Structure Infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Proteus vulgaris, Providencia stuartii, Morganella morganii, Citrobacter freundii, Pseudomonas aeruginosa, methicillin susceptible Staphylococcus aureus, methicillin susceptible Staphylococcus epidermidis, or Streptococcus pyogenes. Bone and Joint Infections caused by Enterobacter cloacae, Serratia marcescens, or Pseudomonas aeruginosa. Complicated Intra-Abdominal Infections (used in combination with metronidazole) caused by Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, or Bacteroides fragilis. Infectious Diarrhea caused by Escherichia coli (enterotoxigenic strains), Campylobacter jejuni, Shigella boydii † , Shigella dysenteriae, Shigella flexneri or Shigella sonnei † when antibacterial therapy is indicated. Typhoid Fever (Enteric Fever) caused by Salmonella typhi. NOTE: The efficacy of ciprofloxacin in the eradication of the chronic typhoid carrier state has not been demonstrated. Uncomplicated cervical and urethral gonorrhea due to Neisseria gonorrhoeae. Pediatric patients (1 to 17 years of age)Complicated Urinary Tract Infections and Pyelonephritis due to Escherichia coli. NOTE: Although effective in clinical trials, ciprofloxacin is not a drug of first choice in the pediatric population due to an increased incidence of adverse events compared to controls, including events related to joints and/or surrounding tissues. (See WARNINGS, PRECAUTIONS, Pediatric Use , ADVERSE REACTIONS and CLINICAL STUDIES .) Ciprofloxacin, like other fluoroquinolones, is associated with arthropathy and histopathological changes in weight-bearing joints of juvenile animals. (See ANIMAL PHARMACOLOGY .) Adult and Pediatric PatientsInhalational anthrax (post-exposure): To reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis. Ciprofloxacin serum concentrations achieved in humans served as a surrogate endpoint reasonably likely to predict clinical benefit and provided the initial basis for approval of this indication.5 Supportive clinical information for ciprofloxacin for anthrax post-exposure prophylaxis was obtained during the anthrax bioterror attacks of October 2001. (See also, INHALATIONAL ANTHRAX – ADDITIONAL INFORMATION ). †Although treatment of infections due to this organism in this organ system demonstrated a clinically significant outcome, efficacy was studied in fewer than 10 patients. If anaerobic organisms are suspected of contributing to the infection, appropriate therapy should be administered. Appropriate culture and susceptibility tests should be performed before treatment in order to isolate and identify organisms causing infection and to determine their susceptibility to ciprofloxacin. Therapy with Ciprofloxacin Tablets may be initiated before results of these tests are known; once results become available appropriate therapy should be continued. As with other drugs, some strains of Pseudomonas aeruginosa may develop resistance fairly rapidly during treatment with ciprofloxacin. Culture and susceptibility testing performed periodically during therapy will provide information not only on the therapeutic effect of the antimicrobial agent but also on the possible emergence of bacterial resistance. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ciprofloxacin Tablets and other antibacterial drugs, Ciprofloxacin Tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Launch Date

1990
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
2.97 μg/mL
500 mg 2 times / day steady-state, oral
dose: 500 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
4.56 μg/mL
400 mg 2 times / day steady-state, intravenous
dose: 400 mg
route of administration: Intravenous
experiment type: STEADY-STATE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
3.59 μg/mL
750 mg 2 times / day steady-state, oral
dose: 750 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
4.07 μg/mL
400 mg 3 times / day steady-state, intravenous
dose: 400 mg
route of administration: Intravenous
experiment type: STEADY-STATE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
1.2 μg/mL
250 mg single, oral
dose: 250 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
2.4 μg/mL
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
4.3 μg/mL
750 mg single, oral
dose: 750 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
5.4 μg/mL
1000 mg single, oral
dose: 1000 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
13.7 μg × h/mL
500 mg 2 times / day steady-state, oral
dose: 500 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
12.7 μg × h/mL
400 mg 2 times / day steady-state, intravenous
dose: 400 mg
route of administration: Intravenous
experiment type: STEADY-STATE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
31.6 μg × h/mL
750 mg 2 times / day steady-state, oral
dose: 750 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
32.9 μg × h/mL
400 mg 3 times / day steady-state, intravenous
dose: 400 mg
route of administration: Intravenous
experiment type: STEADY-STATE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
4.8 μg × h/mL
250 mg single, oral
dose: 250 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
11.6 μg × h/mL
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
20.2 μg × h/mL
750 mg single, oral
dose: 750 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
30.8 μg × h/mL
1000 mg single, oral
dose: 1000 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
4 h
500 mg 2 times / day steady-state, oral
dose: 500 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
4 h
250 mg single, oral
dose: 250 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
4 h
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
4 h
750 mg single, oral
dose: 750 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
4 h
1000 mg single, oral
dose: 1000 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
30%
500 mg 2 times / day steady-state, oral
dose: 500 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
CIPROFLOXACIN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
15 mg/kg 2 times / day steady, oral
Recommended
Dose: 15 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 15 mg/kg, 2 times / day
Sources:
unhealthy, 1 - 17 years
Health Status: unhealthy
Age Group: 1 - 17 years
Sex: unknown
Sources:
Disc. AE: Reaction gastrointestinal...
Other AEs: Musculoskeletal disorder NOS...
AEs leading to
discontinuation/dose reduction:
Reaction gastrointestinal (3%)
Other AEs:
Musculoskeletal disorder NOS (9.3%)
Sources:
7.5 g single, oral
Overdose
Dose: 7.5 g
Route: oral
Route: single
Dose: 7.5 g
Sources:
unhealthy, 15 years
Health Status: unhealthy
Age Group: 15 years
Sex: F
Sources:
Disc. AE: Renal tubular necrosis acute...
AEs leading to
discontinuation/dose reduction:
Renal tubular necrosis acute (1 patient)
Sources:
12 g single, oral
Overdose
Dose: 12 g
Route: oral
Route: single
Dose: 12 g
Sources:
healthy, 16 years
Health Status: healthy
Age Group: 16 years
Sex: M
Sources:
Disc. AE: Pain epigastric...
AEs leading to
discontinuation/dose reduction:
Pain epigastric (1 patient)
Sources:
20 mg/kg single, oral
Recommended
Dose: 20 mg/kg
Route: oral
Route: single
Dose: 20 mg/kg
Sources:
unhealthy, 2-15 years
Health Status: unhealthy
Age Group: 2-15 years
Sex: M+F
Sources:
Other AEs: Vomited...
Other AEs:
Vomited (58%)
Sources:
28 g single, oral
Overdose
Dose: 28 g
Route: oral
Route: single
Dose: 28 g
Sources:
healthy, 29 years
Health Status: healthy
Age Group: 29 years
Sex: F
Sources:
Disc. AE: Acute renal failure...
AEs leading to
discontinuation/dose reduction:
Acute renal failure (1 patient)
Sources:
750 mg 2 times / day steady, oral
Highest studied dose
Dose: 750 mg, 2 times / day
Route: oral
Route: steady
Dose: 750 mg, 2 times / day
Sources:
unhealthy, > 70 years
Health Status: unhealthy
Age Group: > 70 years
Sex: M+F
Sources:
Disc. AE: Acute renal failure...
AEs leading to
discontinuation/dose reduction:
Acute renal failure (2 patients)
Sources:
3 g single, oral
Overdose
Dose: 3 g
Route: oral
Route: single
Dose: 3 g
Sources:
healthy, adult
Health Status: healthy
Age Group: adult
Sex: unknown
Sources:
Disc. AE: Nausea and vomiting...
AEs leading to
discontinuation/dose reduction:
Nausea and vomiting (2 patients)
Sources:
228 mg 2 times / day steady, intravenous
Recommended
Dose: 228 mg, 2 times / day
Route: intravenous
Route: steady
Dose: 228 mg, 2 times / day
Sources:
unhealthy, mean 50 years
Health Status: unhealthy
Age Group: mean 50 years
Sex: M+F
Sources:
Other AEs: Infusion site reactions, Gastrointestinal disorder (NOS)...
Other AEs:
Infusion site reactions (4.4%)
Gastrointestinal disorder (NOS) (3%)
Central nervous system disorder NOS (1.8%)
Sources:
10 mg/kg 2 times / day steady, intravenous
Recommended
Dose: 10 mg/kg, 2 times / day
Route: intravenous
Route: steady
Dose: 10 mg/kg, 2 times / day
Sources:
unhealthy, preterm neonates
Health Status: unhealthy
Age Group: preterm neonates
Sex: unknown
Sources:
Disc. AE: Death...
AEs leading to
discontinuation/dose reduction:
Death (grade 5, 3 patients)
Sources:
500 mg 2 times / day steady, oral
Recommended
Dose: 500 mg, 2 times / day
Route: oral
Route: steady
Dose: 500 mg, 2 times / day
Sources:
unhealthy, ≥18 years
Health Status: unhealthy
Age Group: ≥18 years
Sex: F
Sources:
Disc. AE: Myalgia...
AEs leading to
discontinuation/dose reduction:
Myalgia (2 patients)
Sources:
500 mg 2 times / day steady, oral
Recommended
Dose: 500 mg, 2 times / day
Route: oral
Route: steady
Dose: 500 mg, 2 times / day
Sources:
unhealthy, ≥18 years
Health Status: unhealthy
Age Group: ≥18 years
Sex: F
Sources:
Disc. AE: Exanthema...
AEs leading to
discontinuation/dose reduction:
Exanthema (2 patients)
Sources:
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Other AEs: Acute kidney injury, Clostridium difficile infection...
Other AEs:
Acute kidney injury (serious, 8 patients)
Clostridium difficile infection (serious, 1 patient)
Chest pain (serious, 1 patient)
Dysuria (serious, 1 patient)
Epistaxis (serious, 1 patient)
GI bleed (serious, 1 patient)
Hematuria (serious, 1 patient)
Hyperkalemia (serious, 1 patient)
Hypertension malignant (serious, 1 patient)
Myocardial infarction (serious, 1 patient)
Nausea (serious, 1 patient)
Nephrolithiasis (serious, 1 patient)
Neutropenia (serious, 1 patient)
Pain (serious, 1 patient)
Nephrostomy complication (serious, 1 patient)
Radial nerve palsy (serious, 1 patient)
Sepsis (serious, 2 patients)
Small bowel obstruction (serious, 1 patient)
Thrombocytopenia (serious, 1 patient)
Urinary incontinence (serious, 1 patient)
Urinary retention (serious, 3 patients)
Vomiting (serious, 2 patients)
Venous thromboembolism (serious, 5 patients)
Wound complication (serious, 3 patients)
Constipation (below serious, 12 patients)
Headache (below serious, 7 patients)
Hypomagnesemia (below serious, 8 patients)
Insomnia (below serious, 8 patients)
Osteopenia (below serious, 19 patients)
Proteinuria (below serious, 12 patients)
Sources:
500 mg 2 times / day steady, oral
Dose: 500 mg, 2 times / day
Route: oral
Route: steady
Dose: 500 mg, 2 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Other AEs: Diarrhea, Abdominal pain...
Other AEs:
Diarrhea (below serious, 2 patients)
Abdominal pain (below serious, 2 patients)
Headache (below serious, 2 patients)
Sources:
500 mg 2 times / day steady, oral
Dose: 500 mg, 2 times / day
Route: oral
Route: steady
Dose: 500 mg, 2 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Other AEs: Rash...
Other AEs:
Rash (below serious, 1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Reaction gastrointestinal 3%
Disc. AE
15 mg/kg 2 times / day steady, oral
Recommended
Dose: 15 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 15 mg/kg, 2 times / day
Sources:
unhealthy, 1 - 17 years
Health Status: unhealthy
Age Group: 1 - 17 years
Sex: unknown
Sources:
Musculoskeletal disorder NOS 9.3%
15 mg/kg 2 times / day steady, oral
Recommended
Dose: 15 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 15 mg/kg, 2 times / day
Sources:
unhealthy, 1 - 17 years
Health Status: unhealthy
Age Group: 1 - 17 years
Sex: unknown
Sources:
Renal tubular necrosis acute 1 patient
Disc. AE
7.5 g single, oral
Overdose
Dose: 7.5 g
Route: oral
Route: single
Dose: 7.5 g
Sources:
unhealthy, 15 years
Health Status: unhealthy
Age Group: 15 years
Sex: F
Sources:
Pain epigastric 1 patient
Disc. AE
12 g single, oral
Overdose
Dose: 12 g
Route: oral
Route: single
Dose: 12 g
Sources:
healthy, 16 years
Health Status: healthy
Age Group: 16 years
Sex: M
Sources:
Vomited 58%
20 mg/kg single, oral
Recommended
Dose: 20 mg/kg
Route: oral
Route: single
Dose: 20 mg/kg
Sources:
unhealthy, 2-15 years
Health Status: unhealthy
Age Group: 2-15 years
Sex: M+F
Sources:
Acute renal failure 1 patient
Disc. AE
28 g single, oral
Overdose
Dose: 28 g
Route: oral
Route: single
Dose: 28 g
Sources:
healthy, 29 years
Health Status: healthy
Age Group: 29 years
Sex: F
Sources:
Acute renal failure 2 patients
Disc. AE
750 mg 2 times / day steady, oral
Highest studied dose
Dose: 750 mg, 2 times / day
Route: oral
Route: steady
Dose: 750 mg, 2 times / day
Sources:
unhealthy, > 70 years
Health Status: unhealthy
Age Group: > 70 years
Sex: M+F
Sources:
Nausea and vomiting 2 patients
Disc. AE
3 g single, oral
Overdose
Dose: 3 g
Route: oral
Route: single
Dose: 3 g
Sources:
healthy, adult
Health Status: healthy
Age Group: adult
Sex: unknown
Sources:
Central nervous system disorder NOS 1.8%
228 mg 2 times / day steady, intravenous
Recommended
Dose: 228 mg, 2 times / day
Route: intravenous
Route: steady
Dose: 228 mg, 2 times / day
Sources:
unhealthy, mean 50 years
Health Status: unhealthy
Age Group: mean 50 years
Sex: M+F
Sources:
Gastrointestinal disorder (NOS) 3%
228 mg 2 times / day steady, intravenous
Recommended
Dose: 228 mg, 2 times / day
Route: intravenous
Route: steady
Dose: 228 mg, 2 times / day
Sources:
unhealthy, mean 50 years
Health Status: unhealthy
Age Group: mean 50 years
Sex: M+F
Sources:
Infusion site reactions 4.4%
228 mg 2 times / day steady, intravenous
Recommended
Dose: 228 mg, 2 times / day
Route: intravenous
Route: steady
Dose: 228 mg, 2 times / day
Sources:
unhealthy, mean 50 years
Health Status: unhealthy
Age Group: mean 50 years
Sex: M+F
Sources:
Death grade 5, 3 patients
Disc. AE
10 mg/kg 2 times / day steady, intravenous
Recommended
Dose: 10 mg/kg, 2 times / day
Route: intravenous
Route: steady
Dose: 10 mg/kg, 2 times / day
Sources:
unhealthy, preterm neonates
Health Status: unhealthy
Age Group: preterm neonates
Sex: unknown
Sources:
Myalgia 2 patients
Disc. AE
500 mg 2 times / day steady, oral
Recommended
Dose: 500 mg, 2 times / day
Route: oral
Route: steady
Dose: 500 mg, 2 times / day
Sources:
unhealthy, ≥18 years
Health Status: unhealthy
Age Group: ≥18 years
Sex: F
Sources:
Exanthema 2 patients
Disc. AE
500 mg 2 times / day steady, oral
Recommended
Dose: 500 mg, 2 times / day
Route: oral
Route: steady
Dose: 500 mg, 2 times / day
Sources:
unhealthy, ≥18 years
Health Status: unhealthy
Age Group: ≥18 years
Sex: F
Sources:
Constipation below serious, 12 patients
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Proteinuria below serious, 12 patients
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Osteopenia below serious, 19 patients
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Headache below serious, 7 patients
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Hypomagnesemia below serious, 8 patients
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Insomnia below serious, 8 patients
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Chest pain serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Clostridium difficile infection serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Dysuria serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Epistaxis serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
GI bleed serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Hematuria serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Hyperkalemia serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Hypertension malignant serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Myocardial infarction serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Nausea serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Nephrolithiasis serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Nephrostomy complication serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Neutropenia serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Pain serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Radial nerve palsy serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Small bowel obstruction serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Thrombocytopenia serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Urinary incontinence serious, 1 patient
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Sepsis serious, 2 patients
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Vomiting serious, 2 patients
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Urinary retention serious, 3 patients
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Wound complication serious, 3 patients
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Venous thromboembolism serious, 5 patients
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Acute kidney injury serious, 8 patients
500 mg 1 times / day steady, oral
Dose: 500 mg, 1 times / day
Route: oral
Route: steady
Dose: 500 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Abdominal pain below serious, 2 patients
500 mg 2 times / day steady, oral
Dose: 500 mg, 2 times / day
Route: oral
Route: steady
Dose: 500 mg, 2 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Diarrhea below serious, 2 patients
500 mg 2 times / day steady, oral
Dose: 500 mg, 2 times / day
Route: oral
Route: steady
Dose: 500 mg, 2 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Headache below serious, 2 patients
500 mg 2 times / day steady, oral
Dose: 500 mg, 2 times / day
Route: oral
Route: steady
Dose: 500 mg, 2 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Rash below serious, 1 patient
500 mg 2 times / day steady, oral
Dose: 500 mg, 2 times / day
Route: oral
Route: steady
Dose: 500 mg, 2 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Overview

Overview

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
inconclusive [Activation 10 uM]
no [IC50 >10 uM]
no [IC50 >10 uM]
no [IC50 >10 uM]
no [IC50 >10 uM]
no [IC50 >10 uM]
no [IC50 >10 uM]
no [IC50 >10 uM]
no [IC50 >10 uM]
no
no
no
no
no
no
no
yes [Activation 12.5893 uM]
yes [Activation 15.84893 uM]
yes [IC50 >10 uM]
yes
Drug as victimTox targets
PubMed

PubMed

TitleDatePubMed
Alterations in macromolecular composition and cell wall integrity by ciprofloxacin in Mycobacterium smegmatis.
1999 Aug
The 2-pyridone antibacterial agents: 8-position modifications.
1999 Jul
Comparison of sparfloxacin and ciprofloxacin in the treatment of community-acquired acute uncomplicated urinary tract infection in women. Sparfloxacin Multicenter Uncomplicated Urinary Tract Infection Study Group.
1999 Jun
Purification and inhibition by quinolones of DNA gyrases from Mycobacterium avium, Mycobacterium smegmatis and Mycobacterium fortuitum bv. peregrinum.
1999 Sep
Activity of moxifloxacin against mycobacteria.
1999 Sep
Methadone, ciprofloxacin, and adverse drug reactions.
2000 Dec 16
Intracellular targets of moxifloxacin: a comparison with other fluoroquinolones.
2000 May
Ciprofloxacin affects pregnancy loss in CBA/JxDBA/2J mice possibly via elevation of interleukin-3 and granulocyte macrophage-colony stimulating factor production.
2000 Nov
Effect of ciprofloxacin on the activation of the transcription factors nuclear factor kappaB, activator protein-1 and nuclear factor-interleukin-6, and interleukin-6 and interleukin-8 mRNA expression in a human endothelial cell line.
2000 Nov
The role of fluoroquinolones in tuberculosis today.
2001
Activity and spectrum of BMS 284756, a new des-F (6) quinolone, tested against strains of ciprofloxacin-resistant Gram-positive cocci.
2001 Feb
Effect of pre-stain viability on the acid-fast staining characteristics of Mycobacterium species.
2001 Feb
Would you get your Gonorrhoea treated in the north of England?
2001 Feb
Neisseria gonorrhoeae resistant to ciprofloxacin: first report in Cuba.
2001 Feb
Lack of interaction between levofloxacin and oxycodone: pharmacokinetics and drug disposition.
2001 Feb
Treatment of cat-scratch disease.
2001 Feb
Emergence of high level ciprofloxacin resistant Neisseria gonorrhoeae strain in Buenos Aires, Argentina.
2001 Feb
In vitro activity of new quinolones against Clostridium difficile.
2001 Feb
Antibiotic susceptibility of Kingella kingae isolates from respiratory carriers and patients with invasive infections.
2001 Feb
Evaluation of the Mastalex latex agglutination test for methicillin resistance in Staphylococcus aureus grown on different screening media.
2001 Feb
Comparative activities of isepamicin, amikacin, cefepime, and ciprofloxacin alone or in combination with other antibiotics against Stenotrophomonas maltophilia.
2001 Jan
Comamonas acidovorans keratitis in a hydrogel contact lens wearer.
2001 Jan
Microbiological profile of a shipboard environment and the flora on contact lenses of seamen.
2001 Jan
Antimicrobial use and susceptibility rates in isolates from intensive care unit and other nosocomial inpatient and outpatient areas.
2001 Jan
Determination by fluorimetric titration of the ionization constants of ciprofloxacin in solution and in the presence of liposomes.
2001 Jan
Nosocomial pneumonia. Diagnostic and therapeutic considerations.
2001 Jan
Insect wing case: unusual foreign body.
2001 Jan
Efficacy of ofloxacin and other otic preparations for otitis externa.
2001 Jan
Compliance issues related to the selection of antibiotic suspensions for children.
2001 Jan
Gene expression changes triggered by exposure of Haemophilus influenzae to novobiocin or ciprofloxacin: combined transcription and translation analysis.
2001 Jan
Comparison of serum bactericidal activity of ceftazidime, ciprofloxacin and meropenem against Stenotrophomonas maltophilia.
2001 Jan
In vitro Gram-positive antimicrobial activity of evernimicin (SCH 27899), a novel oligosaccharide, compared with other antimicrobials: a multicentre international trial.
2001 Jan
Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG.
2001 Jan
[Acute pyelonephritis. Randomized multicenter double-blind study comparing ciprofloxacin with combined ciprofloxacin and tobramycin].
2001 Jan 13
Pediatric travel consultation in an integrated clinic.
2001 Jan-Feb
Radical meatoplasty in the treatment of severe chronic external otitis.
2001 Jan-Feb
Depression or hypoactive delirium? A report of ciprofloxacin-induced mental disorder in a patient with chronic obstructive pulmonary disease.
2001 Jan-Feb
In vitro development of resistance to three quinolones in Streptococcus pneumoniae.
2001 Jan-Feb
Bacteriologic and clinical efficacy of ofloxacin 0.3% versus ciprofloxacin 0.3% ophthalmic solutions in the treatment of patients with culture-positive bacterial keratitis.
2001 Mar
Chryseobacterium (Flavobacterium) meningosepticum outbreak associated with colonization of water taps in a neonatal intensive care unit.
2001 Mar
A case of rhinoscleroma treated with ciprofloxacin.
2001 Mar
Chryseobacterium in burn wounds.
2001 Mar
Factors associated with antibiotic resistance in coliform organisms from community urinary tract infection in Wales.
2001 Mar
Antimicrobial activity of fluoroquinolone photodegradation products determined by parallel-line bioassay and high performance liquid chromatography.
2001 Mar
Ciprofloxacin resistance in gonococci.
2001 Mar 10
What have we learned from pharmacokinetic and pharmacodynamic theories?
2001 Mar 15
Successful treatment of an infant with Chromobacterium violaceum sepsis.
2001 Mar 15
Treatment failure with the use of ciprofloxacin for gonorrhea correlates with the prevalence of fluoroquinolone-resistant Neisseria gonorrhoeae strains in Bangladesh.
2001 Mar 15
In vitro activity of gemifloxacin against Streptococcus pneumoniae isolates in Germany.
2001 Mar-Apr
Association between antibiotic resistance and the expression of Dr adhesin among uropathogenic Escherichia coli.
2001 Mar-Apr
Patents

Sample Use Guides

Skin and Skin Structure 500 -750 mg every 12 hours 7 to 14 days Bone and Joint 500-750 mg every 12 hours 4 to 8 weeks Complicated Intra-Abdominal 500 mg every 12 hours 7 to 14 days Infectious Diarrhea 500 mg every 12 hours 5 to 7 days Typhoid Fever 500 mg every 12 hours 10 days Uncomplicated Gonorrhea 250 mg single dose single dose Inhalational anthrax (pos-exposure) 500 mg every 12 hours 60 days Plague 500–750 mg every 12 hours 14 days Chronic Bacterial Prostatitis 500 mg every 12 hours 28 days Lower Respiratory Tract 500 -750 mg every 12 hours 7 to 14 days Urinary Tract 250-500 mg every 12 hours 7 to 14 days Acute Uncomplicated Cystitis 250 mg every 12 hours 3 days Acute Sinusitis 500 mg every 12 hours 10 days
Route of Administration: Oral
Eight hospital isolates of methicillin-resistant and two standard strains of S. epidermidis (ATCC 12228, ATCC 35984) were cultured overnight in Tryptone Soy Broth supplemented with 0.5% glucose. The solution of tested compounds in TSB-glucose medium were mixed (1:1) with the bacterial inoculums (10^7 CFU/mL) in sterile 96-well polystyrene microtiter plates (Karell - Medlab, Italy) and incubated at 37 C for 24 h. Ciprofloxacin was used as the reference antimicrobial compound; its final concentration ranged from 0.125 to 8 mkg/ml.
Substance Class Chemical
Created
by admin
on Mon Mar 31 21:10:01 GMT 2025
Edited
by admin
on Mon Mar 31 21:10:01 GMT 2025
Record UNII
G43NV09DD4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
3-QUINOLINECARBOXYLIC ACID, 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-, HYDROCHLORIDE, HYDRATE (2:2:3)
Preferred Name English
CIPROFLOXACIN HYDROCHLORIDE SESQUIHYDRATE
Common Name English
Code System Code Type Description
PUBCHEM
76961290
Created by admin on Mon Mar 31 21:10:01 GMT 2025 , Edited by admin on Mon Mar 31 21:10:01 GMT 2025
PRIMARY
FDA UNII
G43NV09DD4
Created by admin on Mon Mar 31 21:10:01 GMT 2025 , Edited by admin on Mon Mar 31 21:10:01 GMT 2025
PRIMARY
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ANHYDROUS->SOLVATE
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ACTIVE MOIETY