RANBEZOLID

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H24FN5O6
Molecular Weight	461.4436
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)NC[C@H]1CN(C(=O)O1)C2=CC(F)=C(C=C2)N3CCN(CC4=CC=C(O4)[N+]([O-])=O)CC3

InChI

InChIKey=PWHNTOQANLCTHN-KRWDZBQOSA-N

InChI=1S/C21H24FN5O6/c1-14(28)23-11-17-13-26(21(29)33-17)15-2-4-19(18(22)10-15)25-8-6-24(7-9-25)12-16-3-5-20(32-16)27(30)31/h2-5,10,17H,6-9,11-13H2,1H3,(H,23,28)/t17-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H24FN5O6
Molecular Weight	461.4436
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:03:29 GMT 2023` Edited by `admin` on `Sat Dec 16 11:03:29 GMT 2023`
Record UNII	G3NB6JBL8A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RANBEZOLID

Common Name

English

ACETAMIDE, N-(((5S)-3-(3-FLUORO-4-(4-((5-NITRO-2-FURANYL)METHYL)-1-PIPERAZINYL)PHENYL)-2-OXO-5-OXAZOLIDINYL)METHYL)-

Systematic Name

English

N-(((5S)-3-(3-FLUORO-4-(4-((5-NITRO-2-FURYL)METHYL)PIPERAZIN-1-YL)PHENYL)-2-OXO-OXAZOLIDIN-5-YL)METHYL)ACETAMIDE

Systematic Name

English

Code System Code Type Description

PUBCHEM

496993

Created by admin on Sat Dec 16 11:03:29 GMT 2023 , Edited by admin on Sat Dec 16 11:03:29 GMT 2023

PRIMARY

EPA CompTox

DTXSID701029733

Created by admin on Sat Dec 16 11:03:29 GMT 2023 , Edited by admin on Sat Dec 16 11:03:29 GMT 2023

PRIMARY

CAS

392659-38-0

Created by admin on Sat Dec 16 11:03:29 GMT 2023 , Edited by admin on Sat Dec 16 11:03:29 GMT 2023

PRIMARY

FDA UNII

G3NB6JBL8A

Created by admin on Sat Dec 16 11:03:29 GMT 2023 , Edited by admin on Sat Dec 16 11:03:29 GMT 2023

PRIMARY

Related Record Type Details


					G3NB6JBL8A

RANBEZOLID

ACTIVE MOIETY

Comments:

Summary of MICs (micrograms per milliliter) of Ranbezolid for S. aureus strains. Methicillin-resistant S. aureus(n 68): MIC range = 0.25-4, MIC50 = 2, MIC90 = 4 Methicillin-susceptible S. aureus(n 65): MIC range = 0.5-4, MIC50 = 2, MIC90 = 2


					G3NB6JBL8A

RANBEZOLID

ACTIVE MOIETY

Comments:

For 260 pneumococcal and 266 staphylococcal strains, ranbezolid MICs ranged from 0.06 to 4 .MU.g/ml. The MICs for pneumococci were similar irrespective of the strains' .BETA.-lactam, macrolide, or quinolone susceptibilities, and ranbezolid MICs for coagulase-negative staphylococci were lower than those for Staphylococcus aureus. Ranbezolid was bacteriostatic against pneumococci. Ranbezolid MICs were similar to or lower than those of linezolid.