Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H11F3N2OS |
| Molecular Weight | 312.31 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC(F)(F)C1=CC=C(C=C1)C2=NC(=O)C3=C(CCSC3)N2
InChI
InChIKey=KLGQSVMIPOVQAX-UHFFFAOYSA-N
InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
| Molecular Formula | C14H11F3N2OS |
| Molecular Weight | 312.31 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Sample Use Guides
SH-SY5Y cells, was inhibited by XAV939. XAV939 treatment led to the reduction of β-catenin within the cells, confirming its inhibitory effect of WNT. The inhibition of WNT signaling by XAV939 did not affect cell morphology, survival, and proliferation; however, the differentiation and sensitivity to anticancer drugs of human neuroblastoma cells were altered. The treatment of XAV939 resulted in the downregulation of mature neuronal markers, including β-tubulin III, PHOX2A, and PHOX2B, whereas neural progenitor markers (PAX6, TFAP2α, and SLUG) were upregulated.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 20:19:51 GMT 2023
by
admin
on
Sat Dec 16 20:19:51 GMT 2023
|
| Record UNII |
G2MY39VR77
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Code | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
284028-89-3
Created by
admin on Sat Dec 16 20:19:52 GMT 2023 , Edited by admin on Sat Dec 16 20:19:52 GMT 2023
|
PRIMARY | |||
|
G2MY39VR77
Created by
admin on Sat Dec 16 20:19:52 GMT 2023 , Edited by admin on Sat Dec 16 20:19:52 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET -> INHIBITOR |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |
|
