PRIZIDILOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H25N5O2
Molecular Weight	331.4127
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)NCC(O)COC1=CC=CC=C1C2=NN=C(NN)C=C2

InChI

InChIKey=QGONODUKOFNSOY-UHFFFAOYSA-N

InChI=1S/C17H25N5O2/c1-17(2,3)19-10-12(23)11-24-15-7-5-4-6-13(15)14-8-9-16(20-18)22-21-14/h4-9,12,19,23H,10-11,18H2,1-3H3,(H,20,22)

HIDE SMILES / InChI

Molecular Formula	C17H25N5O2
Molecular Weight	331.4127
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6196556 | https://www.ncbi.nlm.nih.gov/pubmed/6151998 | https://www.ncbi.nlm.nih.gov/pubmed/2427813 | https://www.ncbi.nlm.nih.gov/pubmed/6151553 | https://www.ncbi.nlm.nih.gov/pubmed/7188585

Prizidilol (also known as SKF 92657) is arylpyridazinylhydrazine derivative patented by Smith Kline and French Laboratories Ltd. as an antihypertensive agent. In clinical trials, Supine and standing blood pressure measured 24--27 h after drug intake was reduced Slight but significant decreases in heart rate were seen after moderate doses of prizidilol. A more pronounced blood pressure reduction was noticed 2--7 h after drug administration. Prizidilol was well tolerated, although dizziness and tiredness were reported by four patients and edema by two.

Originator

Approval Year

PubMed

Title	Date	PubMed
SK&F 92657, a novel antihypertensive acting by precapillary vasodilatation and beta-adrenoreceptor blockade.	1979 Dec	44235
Studies on the autonomic nervous system with SK&F 92657, a new antihypertensive agent causing direct arterial vasodilatation and beta-adrenoceptor blockade.	1981 Mar-Apr	6166806
Hemodynamic profile of a new antihypertensive agent D,L-3-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine (SK&F 92657).	1981 Mar-Apr	6166805
Clinical pharmacology and pharmacokinetics of prizidilol in hypertensive patients.	1983 Nov-Dec	6196556

Patents

Sample Use Guides

In Vivo Use Guide

600 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:59:00 GMT 2023` Edited by `admin` on `Sat Dec 16 17:59:00 GMT 2023`
Record UNII	G29795CN0B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PRIZIDILOL

Official Name

English

Prizidilol [WHO-DD]

Common Name

English

SK&F-92657

Code

English

prizidilol [INN]

Common Name

English

2-PROPANOL, 1-((1,1-DIMETHYLETHYL)AMINO)-3-(2-(6-HYDRAZINO-3-PYRIDAZINYL)PHENOXY)-

Systematic Name

English

3(2H)-PYRIDAZINONE, 6-(2-(3-((1,1-DIMETHYLETHYL)AMINO)-2-HYDROXYPROPOXY)PHENYL)-, HYDRAZONE

Systematic Name

English

1-(TERT-BUTYLAMINO)-3-(O-(6-HYDRAZINO-3-PYRIDAZINYL)PHENOXY)-2-PROPANOL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576