PRIZIDILOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H25N5O2
Molecular Weight	331.4127
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)NCC(O)COC1=CC=CC=C1C2=NN=C(NN)C=C2

InChI

InChIKey=QGONODUKOFNSOY-UHFFFAOYSA-N

InChI=1S/C17H25N5O2/c1-17(2,3)19-10-12(23)11-24-15-7-5-4-6-13(15)14-8-9-16(20-18)22-21-14/h4-9,12,19,23H,10-11,18H2,1-3H3,(H,20,22)

HIDE SMILES / InChI

Molecular Formula	C17H25N5O2
Molecular Weight	331.4127
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6196556 | https://www.ncbi.nlm.nih.gov/pubmed/6151998 | https://www.ncbi.nlm.nih.gov/pubmed/2427813 | https://www.ncbi.nlm.nih.gov/pubmed/6151553 | https://www.ncbi.nlm.nih.gov/pubmed/7188585

Prizidilol (also known as SKF 92657) is arylpyridazinylhydrazine derivative patented by Smith Kline and French Laboratories Ltd. as an antihypertensive agent. In clinical trials, Supine and standing blood pressure measured 24--27 h after drug intake was reduced Slight but significant decreases in heart rate were seen after moderate doses of prizidilol. A more pronounced blood pressure reduction was noticed 2--7 h after drug administration. Prizidilol was well tolerated, although dizziness and tiredness were reported by four patients and edema by two.

Originator

Approval Year

PubMed

Title	Date	PubMed
Clinical pharmacology and pharmacokinetics of prizidilol in hypertensive patients.	1983-11-01	6196556
Studies on the autonomic nervous system with SK&F 92657, a new antihypertensive agent causing direct arterial vasodilatation and beta-adrenoceptor blockade.	1981-03-01	6166806
Hemodynamic profile of a new antihypertensive agent D,L-3-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine (SK&F 92657).	1981-03-01	6166805
SK&F 92657, a novel antihypertensive acting by precapillary vasodilatation and beta-adrenoreceptor blockade.	1979-12	44235

Patents

Sample Use Guides

In Vivo Use Guide

600 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:53:22 GMT 2025` Edited by `admin` on `Wed Apr 02 09:53:22 GMT 2025`
Record UNII	G29795CN0B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SK&F-92657

Preferred Name

English

PRIZIDILOL

Official Name

English

Prizidilol [WHO-DD]

Common Name

English

prizidilol [INN]

Common Name

English

2-PROPANOL, 1-((1,1-DIMETHYLETHYL)AMINO)-3-(2-(6-HYDRAZINO-3-PYRIDAZINYL)PHENOXY)-

Systematic Name

English

3(2H)-PYRIDAZINONE, 6-(2-(3-((1,1-DIMETHYLETHYL)AMINO)-2-HYDROXYPROPOXY)PHENYL)-, HYDRAZONE

Systematic Name

English

1-(TERT-BUTYLAMINO)-3-(O-(6-HYDRAZINO-3-PYRIDAZINYL)PHENOXY)-2-PROPANOL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576