MDL-72527 FREE BASE

C=C=CCNCCCCNCC=C=C

InChIKey=IKSQCMLJDHRWOA-UHFFFAOYSA-N

InChI=1S/C12H20N2/c1-3-5-9-13-11-7-8-12-14-10-6-4-2/h5-6,13-14H,1-2,7-12H2

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	2
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Polyamine oxidase 2 Target ID: CHEMBL2105 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12458962	Inhibitor 8297		90.0 nM [Ki]

PubMed

Title	Date	PubMed
Inhibition of pig liver and Zea mays L. polyamine oxidase: a comparative study.	2001	11342283
How important is the oxidative degradation of spermine?: minireview article.	2004 Jul	15290336
Cytotoxicity of the polyamine oxidase inactivator MDL 72527 to cancer cells: comparison with a saturated structural analogue.	2005 Dec	16273223
Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527.	2006 Oct	16962187
Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis.	2007 Nov	17675337

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:45:54 GMT 2023` Edited by `admin` on `Fri Dec 15 17:45:54 GMT 2023`
Record UNII	G28L05X0YB
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

MDL-72527 FREE BASE

Common Name

English

1,4-BUTANEDIAMINE, N1,N4-DI-2,3-BUTADIEN-1-YL-

Systematic Name

English

1,4-BUTANEDIAMINE, N,N'-DI-2,3-BUTADIENYL-

Systematic Name

English

N1,N4-BIS(2,3-BUTADIENYL)-1,4-BUTANEDIAMINE

Systematic Name

English

Code System Code Type Description

PUBCHEM

4026