ETHYBENZTROPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H27NO
Molecular Weight	321.4559
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=PHTMLLGDZBZXMW-AERCQKQUSA-N

InChI=1S/C22H27NO/c1-2-23-19-13-14-20(23)16-21(15-19)24-22(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-22H,2,13-16H2,1H3/t19-,20+,21+

HIDE SMILES / InChI

Molecular Formula	C22H27NO
Molecular Weight	321.4559
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28872668 | https://www.ncbi.nlm.nih.gov/pubmed/5810005 | https://www.ncbi.nlm.nih.gov/pubmed/2779590

Ethybenzatropine (Ponalid) is an anticholinergic and antihistaminergic drug. It was used as an antiparkinsonian agent. A significant increase in the duration of action of levodopa-induced improvement in parkinsonian symptoms was observed following the administration of ethybenzatropine. Ethybenzatropine also improved, or tended to improve the duration and seventy of onset and end-of-dose levodopa-induced dyskinesias. Thus when levodopa is administered together with etybenzatropine, its length of action on parkinsonian symptoms is prolonged.

Approval Year

PubMed

Title	Date	PubMed
Effects of etybenzatropine and diazepam on levodopa-induced diphasic dyskinesias in Parkinson's disease.	1989	2779590

Sample Use Guides

In Vivo Use Guide

Nine patients with Parkinson’s disease: Levodopa was given orally together with a peripheral DOPA-decarboxylase inhibitor at the usual effective morning dosage for each patient. The same dose of levodopa was administered the next day in addition to ethybenzatropine, 5 mg given i.v. Ethybenzatropine was administered between 0 and 15 min after the first dose of levodopa

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:13:00 UTC 2023` Edited by `admin` on `Fri Dec 15 16:13:00 UTC 2023`
Record UNII	G1X2X9N95N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ETHYBENZTROPINE

Official Name

English

ETYBENZATROPINE

Official Name

English

Etybenzatropine [WHO-DD]

Common Name

English

etybenzatropine [INN]

Common Name

English

ETHYBENZTROPINE [MI]

Common Name

English

UK-738

Code

English

8-AZABICYCLO(3.2.1)OCTANE, 3-(DIPHENYLMETHOXY)-8-ETHYL-, ENDO-

Common Name

English

ETYBENZATROPINE [MART.]

Common Name

English

PANOLID

Brand Name

English

ETHYBENZTROPINE [USAN]

Common Name

English

3α-(Diphenylmethoxy)-8-ethyl-1αH,5αH-nortropane

Common Name

English

Classification Tree Code System Code

WHO-VATC

QN04AC30