U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C15H15FN4O
Molecular Weight 286.3042
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZOLAZEPAM

SMILES

CN1N=C(C)C2=C1N(C)C(=O)CN=C2C3=CC=CC=C3F

InChI

InChIKey=GDSCFOSHSOWNDL-UHFFFAOYSA-N
InChI=1S/C15H15FN4O/c1-9-13-14(10-6-4-5-7-11(10)16)17-8-12(21)19(2)15(13)20(3)18-9/h4-7H,8H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C15H15FN4O
Molecular Weight 286.3042
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Zolazepam is used as an anaesthetic in veterinary medicine. Zolazepam is usually administered in combination with other drugs such as the NMDA antagonist tiletamine. This combination is indicated in cats for restraint or for anesthesia combined with muscle relaxation and in dogs for restraint and minor procedures of short duration requiring mild to moderate analgesia. Used alone, tiletamine does not provide adequate muscle relaxation for abdominal surgical procedures. When combined with zolazepam hydrochloride, good muscle relaxation is generally attained during the phase of deep surgical anesthesia.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
TELAZOL

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Radiographic and electrocardiographic evaluation of cardiac morphology and function in captive cheetahs (Acinonyx jubatus).
2003 Dec
Chemical immobilization of crested porcupines with tiletamine HCl and zolazepam HCl (Zoletil) under field conditions.
2003 Jul
Evaluation of three combinations of anesthetics for use in free-ranging alpine marmots (Marmota marmota).
2003 Jul
Epidural administration of tiletamine/zolazepam in horses.
2004 Apr
Four preanesthetic oral sedation protocols for rhesus macaques (Macaca mulatta).
2004 Dec
Effectiveness of antagonists for tiletamine-zolazepam/xylazine immobilization in female white-tailed deer.
2004 Jul
Effects of tiletamine/zolazepam-romifidine-atropine in ocelots (Leopardus pardalis).
2004 Jul
The effect of tiletamine/zolazepam (Zoletile) combination with xylazine or medetomidine on electroencephalograms in dogs.
2004 May
Field immobilization of raccoons (Procyon lotor) with Telazol and xylazine.
2004 Oct
Anesthetic and physiologic effects of tiletamine, zolazepam, ketamine, and xylazine combination (TKX) in feral cats undergoing surgical sterilization.
2004 Oct
Personal experiences in the use of Zoletil for anaesthesia of the red-necked wallaby (Macropus rufogriseus).
2005 Aug
Clinical and cardiorespiratory effects of propofol in the spotted bamboo shark (Chylloscyllium plagiosum).
2005 Dec
Reversible anaesthesia of free-ranging lions (Panthera leo) in Zimbabwe.
2005 Dec
Tiletamine-zolazepam-xylazine immobilization of American marten (Martes americana).
2005 Jul
Determination and evaluation of an optimal dosage of carfentanil and xylazine for the immobilization of white-tailed deer (Odocoileus virginianus).
2005 Jul
Evaluation of two combinations of Domitor, Zoletil 100, and Euthatal to obtain long-term nonrecovery anesthesia in Sprague-Dawley rats.
2005 Jun
[Immobilization of cattle and bison with a combination of xylazine, zolazepam-tiletamine and ketamine].
2005 May 1
Removal of the OptEase retrievable vena cava filter is not feasible after extended time periods because of filter protrusion through the vena cava.
2005 Oct
Chemical immobilisation of wild banteng (Bos javanicus) in northern Australia using detomidine, tiletamine and zolazepam.
2005 Oct
Reversible immobilization of free-ranging African lions (Panthera leo) with medetomidine-tiletamine-zolazepam and atipamezole.
2006 Apr
Cardiopulmonary effects of medetomidine or midazolam in combination with ketamine or tiletamine/zolazepam for the immobilisation of captive cheetahs (Acinonyx jubatus).
2006 Dec
Reversible anesthesia of Southeast Asian primates with medetomidine, zolazepam, and tiletamine.
2006 Dec
Pharmacokinetics of tiletamine and zolazepam (Telazol) in anesthetized pigs.
2006 Dec
Chemical immobilization of adult female Weddell seals with tiletamine and zolazepam: effects of age, condition and stage of lactation.
2006 Feb 9
Effects of epidural morphine and transdermal fentanyl analgesia on physiology and behaviour after abdominal surgery in pigs.
2006 Jan
Immobilization of free-ranging maned wolf (Chrysocyon brachyurus) with tiletamine and zolazepam in central Brazil.
2006 Mar
Determination of constituents of Telazol--tiletamine and zolazepam by a gas chromatography/mass spectrometry-based method.
2006 Oct 2
Immobilization of Japanese black bears (Ursus thibetanus japonicus) with tiletamine hydrochloride and zolazepam hydrochloride.
2007 Apr
Effects of tiletamine-zolazepam anaesthesia on plasma antioxidative status and some haematological parameters in sheep.
2007 Jun
Pseudomyxoma peritonei--two novel orthotopic mouse models portray the PMCA-I histopathologic subtype.
2007 Jun 30
Comparison of cardiovascular effects of tiletamine-zolazepam, pentobarbital, and ketamine-xylazine in male rats.
2007 Mar
Tiletamine-zolazepam and xylazine is a potent cardiodepressive combination: a case report.
2007 Nov
Antagonistic effects of yohimbine in pigs anaesthetised with tiletamine/zolazepam and xylazine.
2007 Nov 3
Serial CT findings of Paragonimus infested dogs and the Micro-CT findings of the worm cysts.
2007 Sep-Oct
Comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol-medetomidine in dogs.
2007 Summer
Reversible immobilization of asiatic black bear (Ursus thibetanus) with detomidine-tiletamine-zolazepam and atipamezole.
2008 Dec
Clinical and pathologic features of cynomolgus macaques (Macaca fascicularis) infected with aerosolized Yersinia pestis.
2008 Feb
Effects of two different anaesthetics on serum concentrations of cortisol and luteinizing hormone in barrows and gilts.
2008 Jan
Changes in minimal alveolar concentration of isoflurane following treatment with medetomidine and tiletamine/zolazepam, epidural morphine or systemic buprenorphine in pigs.
2008 Jan
Echocardiographic reference ranges for sedated healthy cynomolgus monkeys (Macaca fascicularis).
2008 Jan
Biomedical evaluation of free-ranging red ruffed lemurs (Varecia rubra) within the Masoala National Park, Madagascar.
2008 Mar
Effects of premedication with tiletamine/zolazepam/medetomidine during general anesthesia using sevoflurane/fentanyl in swine undergoing pancreas transplantation.
2008 Nov
Evaluation of anesthetic protocol for the collection of semen from captive collared peccaries (Tayassu tajacu) by electroejaculation.
2009 Dec
Biliary clearance of bromosulfophthalein in anesthetized and freely moving conscious rat.
2009 Mar
A pig model of acute Staphylococcus aureus induced pyemia.
2009 Mar 27
Use of two anesthetic combinations for semen collection by electroejaculation from captive coatis (Nasua nasua).
2009 May
Effects of different general anesthetics on serum hemolysis and hepatic and muscular glycogenolysis in rats.
2009 Nov
Movement disorder caused by abuse of veterinary anesthesia containing tiletamine.
2009 Oct
The effect of amnion-derived cellular cytokine solution on the epithelialization of partial-thickness donor site wounds in normal and streptozotocin-induced diabetic swine.
2009 Oct 20
A serological survey of infectious disease in Yellowstone National Park's canid community.
2009 Sep 16
Patents

Patents

Sample Use Guides

Dogs: In healthy dogs, an initial intramuscular dosage of 3 to 4.5 mg/lb (6.6 to 9.9 mg/kg) TELAZOL ((tiletamine HCl and zolazepam HCl) is recommended for diagnostic purposes; 4.5 to 6 mg/lb (9.9 to 13.2 mg/kg) for minor procedures of short duration, such as treatment of lacerations and wounds, castrations and other procedures requiring mild to moderate analgesia. When supplemental doses of TELAZOL are required, such individual supplemental doses should be less than the initial dose, and the total dose given (initial dose plus supplemental dose or doses) should not exceed 12 mg/lb (26.4 mg/kg). The maximum safe dose is 13.6 mg/lb (29.92 mg/kg). Cats: In healthy cats, an initial TELAZOL dosage of 4.4 to 5.4 mg/lb (9.7 to 11.9 mg/kg) is recommended for such procedures as dentistry, treatment of abscesses, foreign body removal and related types of surgery; 4.8 to 5.7 mg/lb (10.6 to 12.5 mg/kg) for minor procedures requiring mild to moderate analgesia, such as repair of lacerations, castrations and other procedures of short duration. Initial dosages of 6.5 to 7.2 mg/lb (14.3 to 15.8 mg/kg) are recommended for ovario- hysterectomy and onychectomy. When supplemental doses of TELAZOL are required, such individual supplemental doses should be given in increments that are less than the initial dose, and the total dose given (initial dose plus supplemental doses) should not exceed the maximum allowable safe dose of 32.7 mg/lb (72 mg/kg).
Route of Administration: Intramuscular
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:22:26 GMT 2023
Edited
by admin
on Fri Dec 15 16:22:26 GMT 2023
Record UNII
G1R474U58U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZOLAZEPAM
INN   MI   WHO-DD  
INN  
Official Name English
PYRAZOLO(3,4-E)(1,4)DIAZEPIN-7(1H)-ONE, 4-(2-FLUOROPHENYL)-6,8-DIHYDRO-1,3,8-TRIMETHYL-
Systematic Name English
4-(O-FLUOROPHENYL)-6,8-DIHYDRO-1,3,8-TRIMETHYLPYRAZOLO(3,4-E)(1,4)DIAZEPIN-7(1H)-ONE
Common Name English
ZOLAZEPAM [MI]
Common Name English
Zolazepam [WHO-DD]
Common Name English
zolazepam [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1012
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
Code System Code Type Description
FDA UNII
G1R474U58U
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY
NCI_THESAURUS
C84252
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY
DRUG BANK
DB11555
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY
EPA CompTox
DTXSID30185278
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY
ChEMBL
CHEMBL2111144
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY
PUBCHEM
35775
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY
MESH
D015041
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY
INN
3311
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY
RXCUI
1535252
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY RxNorm
CAS
31352-82-6
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY
WIKIPEDIA
Zolazepam
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY
MERCK INDEX
m11657
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY Merck Index
DAILYMED
G1R474U58U
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY
SMS_ID
100000078794
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY
EVMPD
SUB00175MIG
Created by admin on Fri Dec 15 16:22:26 GMT 2023 , Edited by admin on Fri Dec 15 16:22:26 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY