| Stereochemistry | ABSOLUTE |
| Molecular Formula | C26H26N2O3 |
| Molecular Weight | 414.4962 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12OC3=C(O)C=CC4=C3[C@@]15CCN(CC6CC6)[C@H](C4)[C@]5(O)CC7=C2NC8=C7C=CC=C8
InChI
InChIKey=WIYUZYBFCWCCQJ-IFKAHUTRSA-N
InChI=1S/C26H26N2O3/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1
| Molecular Formula | C26H26N2O3 |
| Molecular Weight | 414.4962 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Naltrindole is a highly potent, highly selective delta opioid receptor antagonist. It is predominantly used as a molecular probe in biomedical studies exploring the manipulation of delta opioid receptors. Naltrindole was shown to inhibit cancer cell growth in vitro; potentially through a nonopioid receptor-dependant mechanism.
CNS Activity
Approval Year
Sample Use Guides
Naltrindole (0.5 and 1 mg/kg) antagonized swim-stress-induced antinociception in adult and 25-day old rats; but in 20-day old rats, naltrindole (1 mg/kg) had no effect.
Route of Administration:
Intraperitoneal
Stock solutions of Naltrindole were thawed and diluted in Beltsville-Thawing Solution to 200 micro-M. Three 1:10 serial dilutions were made in Beltsville-Thawing Solution. Subsequently, 200 micro-L of standardized Boar Sperm was added to 200 micro-L of Naltrindole solution. The final concentration of Naltrindole was 100, 10, and 1 micro-M. The Naltrindole-Sperm mixtures were incubated at 38 deg-C with shaking, and 25 micro-L aliquots were sampled at 5, 10, 15, 30, and 60 minutes. each aliquot was analyzed for membrane and mitochondrial integrity, including signs of early destabilization, as well as sperm kinematics. Naltrindole did not affect sperm motility at any concentration. However, the highest concentration of naltrindole (100 micro-M) caused a significant decrease in sperm viability after 60 minutes.
