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Details

Stereochemistry UNKNOWN
Molecular Formula C15H22N2O6
Molecular Weight 326.345
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NIPRADILOL

SMILES

CC(C)NCC(O)COC1=C2OCC(CC2=CC=C1)O[N+]([O-])=O

InChI

InChIKey=OMCPLEZZPVJJIS-UHFFFAOYSA-N
InChI=1S/C15H22N2O6/c1-10(2)16-7-12(18)8-21-14-5-3-4-11-6-13(23-17(19)20)9-22-15(11)14/h3-5,10,12-13,16,18H,6-9H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C15H22N2O6
Molecular Weight 326.345
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Nipradilol is a beta blocker and nitric oxide donor. It was launched in Japan in 1988. This medicine lowers intraocular pressure by suppressing aqueous production and increasing fluid drainage from the eye. It is usually used to treat glaucoma and intraocular hypertension. The most commonly reported adverse reactions include conjunctival congestion, superficial keratitis, eye irritation, bloodshot eyes, itch and headache. If any of these symptoms occur, consult with your doctor or pharmacist.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Unknown

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
1 drop at a time, twice a day.
Route of Administration: Other
In Vitro Use Guide
Nipradilol protects rat retinal ganglion cells from apoptosis induced by serum deprivation in vitro. Nipradilol protects RGCs from apoptosis
Substance Class Chemical
Record UNII
FVM336I71Y
Record Status Validated (UNII)
Record Version