Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C20H23NS.ClH |
| Molecular Weight | 345.929 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN1CCCC(CC2C3=C(SC4=C2C=CC=C4)C=CC=C3)C1
InChI
InChIKey=RSXZRFHNNTTWCB-UHFFFAOYSA-N
InChI=1S/C20H23NS.ClH/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20;/h2-5,8-11,15,18H,6-7,12-14H2,1H3;1H
| Molecular Formula | C20H23NS |
| Molecular Weight | 309.468 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Methixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued. Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as metixene is considered to relate to competitive antagonism of acetylcholine at muscarinic receptors in the corpus striatum, which then restores the balance.
CNS Activity
Approval Year
Sample Use Guides
As monotherapy in Parkinson's disease
Adult: As hydrochloride: Initially, 2.5 mg tid; increase gradually depending on clinical response to a total of 15-60 mg daily in divided doses.
Route of Administration:
Oral
When using ( -)3H-QNB to label muscarinic acetylcholine
receptors in rat brain homogenates, the specific binding was
of high affinity and saturable (apparent KD of 0.26k0.18
nM, B, of 2.09 k0.32 pmol/mg protein). Specific binding
of 3H-QNB was competitively and in a concentration-dependent
manner inhibited by methixene with the IC50-value 0.055 uM
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:08:07 GMT 2023
by
admin
on
Fri Dec 15 18:08:07 GMT 2023
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| Record UNII |
FRK5BSL54S
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| Record Status |
Validated (UNII)
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216-300-1
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64722
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FRK5BSL54S
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DTXSID8045359
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admin on Fri Dec 15 18:08:07 GMT 2023 , Edited by admin on Fri Dec 15 18:08:07 GMT 2023
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| Related Record | Type | Details | ||
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SOLVATE->ANHYDROUS | |||
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |