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Details

Stereochemistry ACHIRAL
Molecular Formula C14H14N3O5S2.Na
Molecular Weight 391.398
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ACETOSULFONE SODIUM

SMILES

[Na+].CC(=O)[N-]S(=O)(=O)C1=CC(N)=CC=C1S(=O)(=O)C2=CC=C(N)C=C2

InChI

InChIKey=PVGBHEUCHKGFQP-UHFFFAOYSA-M
InChI=1S/C14H15N3O5S2.Na/c1-9(18)17-24(21,22)14-8-11(16)4-7-13(14)23(19,20)12-5-2-10(15)3-6-12;/h2-8H,15-16H2,1H3,(H,17,18);/q;+1/p-1

HIDE SMILES / InChI
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C14H15N3O5S2
Molecular Weight 369.416
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Acetosulfone (promacetin®) (sodium 4,4′-diaminodiphenylsulfone-2-acetylsulfonamide) is much less toxic sulfone than sulfoxone sodium (diasone®). Acetosulfone is an antibacterial agent. It has been used in the treatment of leprosy, has been under study in the Department of Dermatology at the University of Cincinnati College of Medicine since 1949. Acetosulfone was also used for the treatment of sarcoidosis. It was tested in the treatment of the Duhring's disease.

Approval Year

1952
115
Sourcing

Sourcing

Vendor/AggregatorIDURL
ABI Chem
AC1L1LJE
BLD Pharm
BD680286
http://www.bldpharm.com/products/80-80-8.html
BOC Sciences
80-80-8
ChemMol
99155721
http://www.chemmol.com/chemmol/99155721.html
ChemTik
CTK5E8165
Chemieliva Pharmaceutical Co., Ltd
PBCM1422371
Compound Cloud
11954271
Compound Cloud
31400
THE BioTek
bt-430067
https://www.thebiotek.com/product/others/bt-430067
ZINC
ZINC000005179118
http://zinc15.docking.org/substances/ZINC000005179118
eMolecules
107051849
PubMed

PubMed

TitleDatePubMed
Sulfone drugs in Duhring's disease; further experience.
1956 Jun
[Treatment of Duhring's herpes dermatitis with acetosulfone].
1972 Oct 15
Patents

Patents

EP1423107A2
4
WO2015023797A9
2

Sample Use Guides

In Vivo Use Guide
Dermatitis herpetiformis: Daily dose of three grams for a maintenance dose
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:08:01 UTC 2023
Edited
by admin
on Fri Dec 15 15:08:01 UTC 2023
Record UNII
FQ3M2Y4BU3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ACETOSULFONE SODIUM
MI   USAN  
USAN  
Official Name English
ACETOSULFONE SODIUM [USAN]
Common Name English
SULPHADIASULPHONE SODIUM
Common Name English
Sulfadiasulfone sodium [WHO-DD]
Common Name English
SULFADIASULFONE SODIUM [MART.]
Common Name English
IA-307
Code English
ACETOSULPHONE SODIUM
Common Name English
SODIUM ACETOSULFONE
Common Name English
SULFADIASULFONE SODIUM
INN   MART.   WHO-DD  
INN  
Official Name English
N-(6-Sulfanilylmetanilyl)acetamide monosodium salt
Common Name English
ACETOSULFONE SODIUM [MI]
Common Name English
ACETAMIDE, N-((5-AMINO-2-((4-AMINOPHENYL)SULFONYL)PHENYL)SULFONYL)-, MONOSODIUM SALT
Common Name English
CI-100
Code English
sulfadiasulfone sodium [INN]
Common Name English
PROMACETIN
Brand Name English
NSC-107528
Code English
Classification Tree Code System Code
NCI_THESAURUS C849
Created by admin on Fri Dec 15 15:08:01 UTC 2023 , Edited by admin on Fri Dec 15 15:08:01 UTC 2023
Code System Code Type Description
CAS
128-12-1
Created by admin on Fri Dec 15 15:08:01 UTC 2023 , Edited by admin on Fri Dec 15 15:08:01 UTC 2023
PRIMARY
PUBCHEM
11954271
Created by admin on Fri Dec 15 15:08:01 UTC 2023 , Edited by admin on Fri Dec 15 15:08:01 UTC 2023
PRIMARY
EPA CompTox
DTXSID7022548
Created by admin on Fri Dec 15 15:08:01 UTC 2023 , Edited by admin on Fri Dec 15 15:08:01 UTC 2023
PRIMARY
MERCK INDEX
m543
Created by admin on Fri Dec 15 15:08:01 UTC 2023 , Edited by admin on Fri Dec 15 15:08:01 UTC 2023
PRIMARY Merck Index
EVMPD
SUB10694MIG
Created by admin on Fri Dec 15 15:08:01 UTC 2023 , Edited by admin on Fri Dec 15 15:08:01 UTC 2023
PRIMARY
INN
1971
Created by admin on Fri Dec 15 15:08:01 UTC 2023 , Edited by admin on Fri Dec 15 15:08:01 UTC 2023
PRIMARY
NCI_THESAURUS
C76986
Created by admin on Fri Dec 15 15:08:01 UTC 2023 , Edited by admin on Fri Dec 15 15:08:01 UTC 2023
PRIMARY
NSC
107528
Created by admin on Fri Dec 15 15:08:01 UTC 2023 , Edited by admin on Fri Dec 15 15:08:01 UTC 2023
PRIMARY
ChEMBL
CHEMBL3306903
Created by admin on Fri Dec 15 15:08:01 UTC 2023 , Edited by admin on Fri Dec 15 15:08:01 UTC 2023
PRIMARY
SMS_ID
100000083264
Created by admin on Fri Dec 15 15:08:01 UTC 2023 , Edited by admin on Fri Dec 15 15:08:01 UTC 2023
PRIMARY
FDA UNII
FQ3M2Y4BU3
Created by admin on Fri Dec 15 15:08:01 UTC 2023 , Edited by admin on Fri Dec 15 15:08:01 UTC 2023
PRIMARY
Related Record Type Details
Structure of ACETOSULFONE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of ACETOSULFONE
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