ACETOSULFONE

US Previously Marketed

First approved in 1952

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H15N3O5S2
Molecular Weight	369.416
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)NS(=O)(=O)C1=CC(N)=CC=C1S(=O)(=O)C2=CC=C(N)C=C2

InChI

InChIKey=RAMPGXSXWLFXFU-UHFFFAOYSA-N

InChI=1S/C14H15N3O5S2/c1-9(18)17-24(21,22)14-8-11(16)4-7-13(14)23(19,20)12-5-2-10(15)3-6-12/h2-8H,15-16H2,1H3,(H,17,18)

HIDE SMILES / InChI

Molecular Formula	C14H15N3O5S2
Molecular Weight	369.416
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13346157 | https://www.ncbi.nlm.nih.gov/pubmed/4658749 | https://www.ncbi.nlm.nih.gov/pubmed/14884708

Acetosulfone (promacetin®) (sodium 4,4′-diaminodiphenylsulfone-2-acetylsulfonamide) is much less toxic sulfone than sulfoxone sodium (diasone®). Acetosulfone is an antibacterial agent. It has been used in the treatment of leprosy, has been under study in the Department of Dermatology at the University of Cincinnati College of Medicine since 1949. Acetosulfone was also used for the treatment of sarcoidosis. It was tested in the treatment of the Duhring's disease.

Approval Year

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L1LJE
BLD Pharm	BD680286	http://www.bldpharm.com/products/80-80-8.html
BOC Sciences	80-80-8
Chemieliva Pharmaceutical Co., Ltd	PBCM1422371
ChemMol	99155721	http://www.chemmol.com/chemmol/99155721.html
ChemTik	CTK5E8165
Compound Cloud	11954271
Compound Cloud	31400
eMolecules	107051849
THE BioTek	bt-430067	https://www.thebiotek.com/product/others/bt-430067
ZINC	ZINC000005179118	http://zinc15.docking.org/substances/ZINC000005179118

PubMed

Title	Date	PubMed
[Treatment of Duhring's herpes dermatitis with acetosulfone].	1972-10-15	4658749
Sulfone drugs in Duhring's disease; further experience.	1956-06	13346157

Patents

Sample Use Guides

In Vivo Use Guide

Dermatitis herpetiformis: Daily dose of three grams for a maintenance dose

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:44:48 GMT 2025` Edited by `admin` on `Mon Mar 31 18:44:48 GMT 2025`
Record UNII	ZT389542XK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SULFADIASULFONE

Preferred Name

English

ACETOSULFONE

Common Name

English

ACETOSULPHONE

Common Name

English

ACETAMIDE, N-((5-AMINO-2-((4-AMINOPHENYL)SULFONYL)PHENYL)SULFONYL)-

Systematic Name

English

N-(6-SULFANILYLMETANILYL)ACETAMIDE

Common Name

English

Sulfadiasulfone [WHO-DD]

Common Name

English

SULPHADIASULPHONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C849