FLUROXENE

US Previously Marketed

First approved in 1954

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H5F3O
Molecular Weight	126.0771
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(F)(F)COC=C

InChI

InChIKey=DLEGDLSLRSOURQ-UHFFFAOYSA-N

InChI=1S/C4H5F3O/c1-2-8-3-4(5,6)7/h2H,1,3H2

HIDE SMILES / InChI

Molecular Formula	C4H5F3O
Molecular Weight	126.0771
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugfuture.com/chemdata/fluroxene.html | https://www.ncbi.nlm.nih.gov/pubmed/13420163

FLUROXENE (Fluoromar®) is a colorless, volatile liquid, which was used as an inhalational anesthetic.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4379664 http://www.drugfuture.com/chemdata/fluroxene.html	Primary		Approved 8429	Fluoromar Approved Use Formerly as anesthetic (inhalation). Launch Date 1960

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
P450 1	P450 3

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
P450 1	inhibitor 3277 Sources: https://accessmedicine.mhmedical.com/content.aspx?bookid=2249§ionid=175215930	yes

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
P450 3	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/25763/	yes

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-032275	http://www.3bsc.com/index/pro_info.php?id=53539
AA Blocks	AA003F4J	https://www.aablocks.com/goods/Goods/detail?id=AA003F4J
AEchem Scientific Corp., USA	AE054527	https://www.aechemsc.com/info_products/AE054527.php
AHH Chemical co.,ltd	MT-30734	http://www.ahhchemical.com/product/MT-30734.html
AK Scientific, Inc. (AKSCI)	X2021	http://www.aksci.com/item_detail.php?cat=X2021
Acadechem	ACDS-034242	http://www.acadechemical.com/product/108941
Achemica	ACMC-1AFWH	http://www.achemica.com/prodinfo/?id=4254
Alichem	490025775	http://www.alichem.com/en/products/406-90-6.html
Ambinter	Amb10840029	http://www.ambinter.com/reference/10840029
Chem Scene	CS-4763	http://www.chemscene.com/406-90-6.html
ChemMol	99086774	http://www.chemmol.com/chemmol/99086774.html
Finetech	FT-0609045	http://www.finetechnology-ind.com/prod/detail/pub/406-90-6.html
Lab Network	LN01343393	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01343393
MedChem Express	HY-B1163	https://www.medchemexpress.com/Fluroxene.html
MuseChem	I003485	https://www.musechem.com/product/I003485.html
Parchem	43693	https://www.parchem.com/chemical-supplier-distributor/2-2-2-Trifluoroethyl-vinyl-ether-043693.aspx
Sigma-Aldrich	697435_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/697435?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S018585	http://www.sinfoobiotech.com/product/1021983
Smolecule	S571733	https://www.smolecule.com/products/s571733
THE BioTek	bt-305307	https://www.thebiotek.com/product/others/bt-305307
Yuhao Chemical	LQ0815	http://www.chemyuhao.com/406-90-6.html
abcr GmbH	AB172162	http://www.abcr.com/shop/en/AB172162

PubMed

Title	Date	PubMed
Electroencephalographic seizure activity in dogs during anaesthesia.	1971 Aug	4398198
The effect of enflurane, isoflurane, fluroxene, methoxyflurane and diethyl ether anesthesia on ouabain tolerance in the dog.	1976 May-Jun	5922
Cardiovascular effects of pancuronium in patients anaesthetized with enflurane and fluroxene.	1981 Jan	6113039
General anesthetic actions on GABA(A) receptors.	2010 Mar	20808541

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:09:53 GMT 2023` Edited by `admin` on `Fri Dec 15 15:09:53 GMT 2023`
Record UNII	FO7JHA3G03
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FLUROXENE

Official Name

English

ETHENE, (2,2,2-TRIFLUOROETHOXY)-

Systematic Name

English

2,2,2-Trifluoroethyl vinyl ether

Systematic Name

English

Fluroxene [WHO-DD]

Common Name

English

FLUROXENE [USAN]

Common Name

English

FLUROXENE [MI]

Common Name

English

FLUOROMAR

Brand Name

English

fluroxene [INN]

Common Name

English

NSC-760364

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C245