Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C11H18N2O4S3 |
Molecular Weight | 338.467 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)CN[C@H]1CCS(=O)(=O)C2=C1C=C(S2)S(N)(=O)=O
InChI
InChIKey=JFLUCCKXAYBETQ-VIFPVBQESA-N
InChI=1S/C11H18N2O4S3/c1-7(2)6-13-9-3-4-19(14,15)11-8(9)5-10(18-11)20(12,16)17/h5,7,9,13H,3-4,6H2,1-2H3,(H2,12,16,17)/t9-/m0/s1
Molecular Formula | C11H18N2O4S3 |
Molecular Weight | 338.467 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Sezolamide (previously known as MK-417), a potent carbonic anhydrase inhibitor capable of reducing intraocular pressure after topical application, was under investigation for the treatment of glaucoma. . Sezolamide is the more potent of the two stereo isomers of MK-927 in inhibiting human carbonic anhydrase isoenzyme II, the isoenzyme found in ciliary processes. Sezolamide, the S-enantiomer of MK-927, has demonstrated activity in vitro approximately 80 times that of the R-enantiomer of MK-927 (concentrations of 0.54 nmolll and 44 nM, respectively, inhibiting activity of human carbonic anhydrase isoenzyme II by 50%). Clinically, sezolamide has also demonstrated greater activity than MK-927 both after single-dose and after twice daily administration in
patients.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1286720
A maximum intraocular pressure lowering
activity from time-matched baseline diurnal curve values
of about 20% was observed after multiple-dose twice daily administration of 1.8% sezolamide in patients with
primary open angle glaucoma or ocular hypertension.
Route of Administration:
Topical
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:52:02 GMT 2023
by
admin
on
Fri Dec 15 18:52:02 GMT 2023
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Record UNII |
FC9C0XB7D4
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Record Status |
Validated (UNII)
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Record Version |
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-
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NCI_THESAURUS |
C29577
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admin on Fri Dec 15 18:52:02 GMT 2023 , Edited by admin on Fri Dec 15 18:52:02 GMT 2023
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100000084325
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C057921
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CHEMBL417975
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C96536
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6540
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60693
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123308-22-5
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SUB10508MIG
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FC9C0XB7D4
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admin on Fri Dec 15 18:52:02 GMT 2023 , Edited by admin on Fri Dec 15 18:52:02 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
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ACTIVE MOIETY |