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Details

Stereochemistry ACHIRAL
Molecular Formula C14H13NO
Molecular Weight 211.2591
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NORLETIMOL

SMILES

OC1=CC=CC=C1\C=N\CC2=CC=CC=C2

InChI

InChIKey=LPSMMAHYAIVSQW-RVDMUPIBSA-N
InChI=1S/C14H13NO/c16-14-9-5-4-8-13(14)11-15-10-12-6-2-1-3-7-12/h1-9,11,16H,10H2/b15-11+

HIDE SMILES / InChI

Molecular Formula C14H13NO
Molecular Weight 211.2591
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Norletimol is a Schiff base with promising anti-inflammatory properties. The time taken for elimination of 50% of the Norletimol dose in the urine was approximately five hours. As an antirheumatic agent it was tested in clinical trials in Iraq. It was used in progressive myopia in children.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Unknown

OverviewOther

Other InhibitorOther SubstrateOther Inducer


Drug as perpetrator​

Drug as victim

Tox targets

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
Rat: 50, 100 and 300 mg/kg Dog: 44, 85 and 300 mg/kg
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
FB45669IEG
Record Status Validated (UNII)
Record Version