ADL-5859

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H28N2O3
Molecular Weight	392.4907
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)C(=O)C1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=CC=CC(O)=C24

InChI

InChIKey=OPIKUXLJQFYMSC-UHFFFAOYSA-N

InChI=1S/C24H28N2O3/c1-3-26(4-2)23(28)18-10-8-17(9-11-18)19-16-24(12-14-25-15-13-24)29-21-7-5-6-20(27)22(19)21/h5-11,16,25,27H,3-4,12-15H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C24H28N2O3
Molecular Weight	392.4907
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.biospace.com/News/adolor-corporation-to-stop-development-of-bowel/120878

ADL5859 (or ADL-5859) is Adolor Corporation developed a novel, oral compound that targets the delta opioid receptor. Delta receptor agonists are thought to offer benefits over other approaches to the management of pain. ADL-5859 was in the phase II of clinical trial for the treatment of neuropathic pain, acute pain, and pain due to osteoarthritis of the knee and for patients with osteoarthritis. Further development of this drug as potential pain treatments was discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Delta opioid receptor 77 Target ID: CHEMBL236 Sources: https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL236	Agonist 2678

Conditions

Condition	Modality	Highest Phase	Product
Acute pain 17 Sources: https://clinicaltrials.gov/ct2/show/NCT00993863	Primary	Phase II 1132	Unknown Approved Use Unknown
Neuropathic pain 26 Sources: https://clinicaltrials.gov/ct2/show/NCT00603265	Primary	Phase II 1132	Unknown Approved Use Unknown
Osteoarthritis of knee 23 Sources: https://clinicaltrials.gov/ct2/show/NCT00979953	Palliative	Phase II 1132	Unknown Approved Use Unknown
Rheumatoid arthritis 316 Sources: https://clinicaltrials.gov/ct2/show/NCT00626275	Palliative	Phase II 1132	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY442979	https://www.001chemical.com/chem/search?q=DY442979
1PlusChem LLC	1P00G43Y	https://www.1pchem.com/search?query=1P00G43Y
A2B Chem	AH51022	http://a2bchem.com/prod/AH51022
AK Scientific	X7606	https://aksci.com/item_detail.php?cat=X7606
AOBIOUS INC	AOB87750	http://aobious.com/aobious/search?search_query=AOB87750
Aceschem	ACS019823	https://www.aceschem.com/catalog/search.do?q=ACS019823
ApexBio Technology	A2986	https://www.apexbt.com/catalogsearch/result/?q=A2986
AstaTech	44006	http://astatechinc.com/CPSResult.php?CRNO=44006
Axon MedChem	1751	https://www.axonmedchem.com/product/1751
BLD Pharm	BD167195	http://www.bldpharm.com/search/Search.html?keyword=BD167195
Capot Chemical	33950	https://www.capotchem.com/search.do?q=33950
Chem Scene	CS-0428	http://www.chemscene.com/goproductList/searchProductList?productObj=CS-0428
ChemShuttle	111934	https://www.chemshuttle.com/catalogsearch/result/?q=111934
Debye Scientific	DB-026462	https://www.debyesci.com/index.php?id=product&ext[cno]=DB-026462
Debye Scientific	DB-076207	https://www.debyesci.com/index.php?id=product&ext[cno]=DB-076207
Excenen	EX-A433	http://www.excenen.com/searchresultlist.php?id=EX-A433
Hairui	HR32976	http://www.hairuichem.com/en/product/search.do?q=HR32976
KeyOrganics	AS-19401	http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=AS-19401
Matrix Scientific	147263	http://www.matrixscientific.com/147263.html
MedChem Express	HY-13044	https://www.medchemexpress.com/search.html?q=HY-13044&ft=&fa=&fp=
MolPort	MolPort-023-293-533	https://www.molport.com/shop/molecule-link/MolPort-023-293-533
Molcore	MC442979	http://www.molcore.com/CatMC442979.html
Molnova	M16172	https://www.molnova.com/en/serch-list.html?keywords=M16172
MuseChem	I001223	https://www.musechem.com/product/I001223.html
ShangHai Biochempartner	BCP000075	http://www.biochempartner.com/search_BCP000075
ShangHai Biochempartner	BCP01728	http://www.biochempartner.com/search_BCP01728
TargetMol	T6175	https://www.targetmol.com/search?keyword=T6175
Toronto Research Chemicals	D442035	https://www.trc-canada.com/product-detail/?CatNum=D442035
Toronto Research Chemicals	P999020	https://www.trc-canada.com/product-detail/?CatNum=P999020
eMolecules	36789191	https://orderbb.emolecules.com/search/#?query=36789191
eNovation Chemicals	D372568	https://www.enovationchem.com/Products.asp?SEARCHTEXT=D372568&searchbtn.x=0&searchbtn.y=0
mcule	MCULE-4080557175	https://mcule.com/MCULE-4080557175/
mcule	MCULE-9818118162	https://mcule.com/MCULE-9818118162/

PubMed

Title	Date	PubMed
		252160419

Sample Use Guides

In Vivo Use Guide

single dose: 30, 100, 200 mg

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:18:26 GMT 2023` Edited by `admin` on `Sat Dec 16 08:18:26 GMT 2023`
Record UNII	FA554TW3UP
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ADL-5859

Common Name

English

BENZAMIDE, N,N-DIETHYL-4-(5-HYDROXYSPIRO(2H-1-BENZOPYRAN-2,4'-PIPERIDIN)-4-YL)-

Systematic Name

English

Code System Code Type Description

FDA UNII

FA554TW3UP

Created by admin on Sat Dec 16 08:18:26 GMT 2023 , Edited by admin on Sat Dec 16 08:18:26 GMT 2023

PRIMARY

CAS

850305-06-5

Created by admin on Sat Dec 16 08:18:26 GMT 2023 , Edited by admin on Sat Dec 16 08:18:26 GMT 2023

PRIMARY

PUBCHEM

11417954

Created by admin on Sat Dec 16 08:18:26 GMT 2023 , Edited by admin on Sat Dec 16 08:18:26 GMT 2023

PRIMARY

Related Record Type Details


					FA554TW3UP

ADL-5859

ACTIVE MOIETY

Details

SMILES

InChI

DescriptionSources: http://www.biospace.com/News/adolor-corporation-to-stop-development-of-bowel/120878

Originator

Approval Year

Targets

Conditions

Approved Use

Approved Use

Approved Use

Approved Use

Sourcing

PubMed

Sample Use Guides

Description
Sources: http://www.biospace.com/News/adolor-corporation-to-stop-development-of-bowel/120878