SARMAZENIL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H14ClN3O3
Molecular Weight	319.743
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=C2CN(C)C(=O)C3=C(Cl)C=CC=C3N2C=N1

InChI

InChIKey=WSDBAFQWNWJTNG-UHFFFAOYSA-N

InChI=1S/C15H14ClN3O3/c1-3-22-15(21)13-11-7-18(2)14(20)12-9(16)5-4-6-10(12)19(11)8-17-13/h4-6,8H,3,7H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C15H14ClN3O3
Molecular Weight	319.743
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22882576 | https://adisinsight.springer.com/drugs/800005900 | https://www.ncbi.nlm.nih.gov/pubmed/15954550

Sarmazenil (previously known as RO 153505) was developed as a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors). This compound is used in veterinary medicine in order to rapidly re-awake anesthetized animals. In addition, this compound was studied in the treatment of a moxidectin intoxication in foals. Sarmazenil was also involved in preclinical development for Alzheimer's disease in the USA. However, the information about the further development of the drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Anaesthesia for the geriatric dog and cat.	2008-06-01	21851715
Balanced anesthesia and ventilation strategies for an alpaca (Lama pacos) with an increased anesthetic-risk.	2008-02	18369052
The use of sarmazenil in the treatment of a moxidectin intoxication in a foal.	2005-06-16	15954550
Effects of midazolam and sarmazenil on the equine electroencephalogram during anaesthesia with halothane in oxygen.	2003-04	12667179
Partial antagonism of tiletamine-zolazepam anesthesia in cheetah.	2002-04	12038151
Sarmazenil-precipitated withdrawal: a reliable method for assessing dependence liability of benzodiazepine receptor ligands.	1998-04	9586852

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:45:28 GMT 2025` Edited by `admin` on `Wed Apr 02 09:45:28 GMT 2025`
Record UNII	F84AE7X24P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SARMAZENIL

Official Name

English

SARMAZOL

Preferred Name

English

RO 15-3505

Code

English

sarmazenil [INN]

Common Name

English

RO-153505

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C28197