SARMAZENIL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H14ClN3O3
Molecular Weight	319.743
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=C2CN(C)C(=O)C3=C(Cl)C=CC=C3N2C=N1

InChI

InChIKey=WSDBAFQWNWJTNG-UHFFFAOYSA-N

InChI=1S/C15H14ClN3O3/c1-3-22-15(21)13-11-7-18(2)14(20)12-9(16)5-4-6-10(12)19(11)8-17-13/h4-6,8H,3,7H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C15H14ClN3O3
Molecular Weight	319.743
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22882576 | https://adisinsight.springer.com/drugs/800005900 | https://www.ncbi.nlm.nih.gov/pubmed/15954550

Sarmazenil (previously known as RO 153505) was developed as a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors). This compound is used in veterinary medicine in order to rapidly re-awake anesthetized animals. In addition, this compound was studied in the treatment of a moxidectin intoxication in foals. Sarmazenil was also involved in preclinical development for Alzheimer's disease in the USA. However, the information about the further development of the drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Sarmazenil-precipitated withdrawal: a reliable method for assessing dependence liability of benzodiazepine receptor ligands.	1998 Apr	9586852
Partial antagonism of tiletamine-zolazepam anesthesia in cheetah.	2002 Apr	12038151
Effects of midazolam and sarmazenil on the equine electroencephalogram during anaesthesia with halothane in oxygen.	2003 Apr	12667179
The use of sarmazenil in the treatment of a moxidectin intoxication in a foal.	2005 May-Jun	15954550
Balanced anesthesia and ventilation strategies for an alpaca (Lama pacos) with an increased anesthetic-risk.	2008 Feb	18369052
Anaesthesia for the geriatric dog and cat.	2008 Jun 1	21851715

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:55:01 GMT 2023` Edited by `admin` on `Sat Dec 16 17:55:01 GMT 2023`
Record UNII	F84AE7X24P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SARMAZENIL

Official Name

English

RO 15-3505

Code

English

sarmazenil [INN]

Common Name

English

SARMAZOL

Brand Name

English

RO-153505

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C28197