Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C61H63N9O17S4.4H |
Molecular Weight | 1326.5015 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 3 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)c2cc(ccc2[N+](=C1C=CC3=C(C(=CC=C4C(C)(C)c5cc(ccc5N4CCCCS(=O)(=O)O)S(=O)(=O)[O-])CCC3)Oc6ccc(cc6)C[C@@]([H])(C(=O)O)NC(=C7C=CC(=NCc8cnc9c(c(nc(=N)[nH]9)O)n8)C=C7)O)CCCCS(=O)(=O)O)S(=O)(=O)O
InChI
InChIKey=PDXNSXLPXJFETD-DYVQZXGMSA-N
InChI=1S/C61H67N9O17S4/c1-60(2)46-33-44(90(81,82)83)22-24-49(46)69(28-5-7-30-88(75,76)77)51(60)26-16-38-10-9-11-39(17-27-52-61(3,4)47-34-45(91(84,85)86)23-25-50(47)70(52)29-6-8-31-89(78,79)80)54(38)87-43-20-12-37(13-21-43)32-48(58(73)74)66-56(71)40-14-18-41(19-15-40)63-35-42-36-64-55-53(65-42)57(72)68-59(62)67-55/h12-27,33-34,36,48H,5-11,28-32,35H2,1-4H3,(H9-,62,63,64,66,67,68,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86)/t48-/m0/s1
Molecular Formula | C61H63N9O17S4 |
Molecular Weight | 1322.4697 |
Charge | -4 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 3 |
Optical Activity | UNSPECIFIED |
Molecular Formula | H |
Molecular Weight | 1.0079 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
OTL-0038 or OTL-38, a fluorescent-labelled folate receptor-α (FRα) targeted imaging agent that accumulates in vivo in tumor cells expressing FR. OTL38 is currently in ongoing Phase 3 clinical trial in ovarian cancer and successfully completed phase 2 clinical trial in lung cancer. OTL38 is being evaluated for its ability to help surgeons locate and remove hard-to-find cancerous lesions that are often widespread. In 2014, the OTL-38 molecule was granted orphan drug status which can be given to the maker of a drug that treats rare conditions or diseases and offers protection from competition for a period of time. In addition, OTL-38 was studied in phase II clinical trials in the Netherlands for the diagnosis of endometriosis.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors: a patent evaluation of US20160011199A1. | 2016 Nov |
|
Folate receptor-α targeted near-infrared fluorescence imaging in high-risk endometrial cancer patients: a tissue microarray and clinical feasibility study. | 2018 Jan 2 |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT03180307
0.025 mg/kg of OTL38 (OTL-0038) in 250ml D5W infused intravenously over 60 minutes
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Jun 25 20:37:51 UTC 2021
by
admin
on
Fri Jun 25 20:37:51 UTC 2021
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Record UNII |
F7BD3Z4X8L
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Record Status |
Validated (UNII)
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Record Version |
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FDA ORPHAN DRUG |
458714
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11569
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DB15413
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C175834
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1628423-76-6
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F7BD3Z4X8L
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135565623
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1983160-11-7
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NO STRUCTURE GIVEN |
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