ABANOQUIL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H25N3O4
Molecular Weight	395.4516
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ABANOQUIL

Structure Search

SMILES

COC1=CC2=C(CN(CC2)C3=NC4=CC(OC)=C(OC)C=C4C(N)=C3)C=C1OC

InChI

InChIKey=ANZIISNSHPKVRV-UHFFFAOYSA-N

InChI=1S/C22H25N3O4/c1-26-18-7-13-5-6-25(12-14(13)8-19(18)27-2)22-10-16(23)15-9-20(28-3)21(29-4)11-17(15)24-22/h7-11H,5-6,12H2,1-4H3,(H2,23,24)

HIDE SMILES / InChI

Molecular Formula	C22H25N3O4
Molecular Weight	395.4516
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10845763

Abanoquil (UK-52,046), an antiarrhythmic drug, is an alpha 1-adrenoceptor antagonist, has been studied for the treatment of erectile dysfunction.

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor alpha-1 169 Target ID: CHEMBL2094251 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10845763	Antagonist 2778

PubMed

PubMed

Title	Date	PubMed
Dose-dependent alpha 1-adrenoceptor antagonist activity of the anti-arrhythmic drug, abanoquil (UK-52,046), without reduction in blood pressure in man.	1992 Apr	1349492
Abanoquil, a new alpha-1 adrenoceptor antagonist. In vitro and in vivo effect on erectile tissue.	2000 Mar	10845763
Abanoquil, a new alpha-1 adrenoceptor antagonist. In vitro and in vivo effect on erectile tissue.	2000 Mar	10849564

Patents

Patents

Sample Use Guides

In Vivo Use Guide

single oral doses of abanoquil 0.25, 0.5 and 1 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:50:36 GMT 2023` Edited by `admin` on `Sat Dec 16 17:50:36 GMT 2023`
Record UNII	F738MWY53L
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ABANOQUIL

Official Name

English

4-AMINO-2-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLYL)-6,7-DIMETHOXYQUINOLINE

Systematic Name

English

abanoquil [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29713

Created by admin on Sat Dec 16 17:50:36 GMT 2023 , Edited by admin on Sat Dec 16 17:50:36 GMT 2023

Code System Code Type Description

WIKIPEDIA

ABANOQUIL

Created by admin on Sat Dec 16 17:50:36 GMT 2023 , Edited by admin on Sat Dec 16 17:50:36 GMT 2023

PRIMARY

FDA UNII

F738MWY53L

Created by admin on Sat Dec 16 17:50:36 GMT 2023 , Edited by admin on Sat Dec 16 17:50:36 GMT 2023

PRIMARY

INN

6761

Created by admin on Sat Dec 16 17:50:36 GMT 2023 , Edited by admin on Sat Dec 16 17:50:36 GMT 2023

PRIMARY

NCI_THESAURUS

C72566

Created by admin on Sat Dec 16 17:50:36 GMT 2023 , Edited by admin on Sat Dec 16 17:50:36 GMT 2023

PRIMARY

MESH

C058534

Created by admin on Sat Dec 16 17:50:36 GMT 2023 , Edited by admin on Sat Dec 16 17:50:36 GMT 2023

PRIMARY

SMS_ID

100000082323

Created by admin on Sat Dec 16 17:50:36 GMT 2023 , Edited by admin on Sat Dec 16 17:50:36 GMT 2023

PRIMARY

PUBCHEM

164089

Created by admin on Sat Dec 16 17:50:36 GMT 2023 , Edited by admin on Sat Dec 16 17:50:36 GMT 2023

PRIMARY

ChEMBL

CHEMBL324090

Created by admin on Sat Dec 16 17:50:36 GMT 2023 , Edited by admin on Sat Dec 16 17:50:36 GMT 2023

PRIMARY

EPA CompTox

DTXSID40238163

Created by admin on Sat Dec 16 17:50:36 GMT 2023 , Edited by admin on Sat Dec 16 17:50:36 GMT 2023

PRIMARY

CAS

90402-40-7

Created by admin on Sat Dec 16 17:50:36 GMT 2023 , Edited by admin on Sat Dec 16 17:50:36 GMT 2023

PRIMARY

EVMPD

SUB07358MIG

Created by admin on Sat Dec 16 17:50:36 GMT 2023 , Edited by admin on Sat Dec 16 17:50:36 GMT 2023

PRIMARY

Related Record Type Details


					F738MWY53L

ABANOQUIL

ACTIVE MOIETY