IOBENZAMIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H13I3N2O3
Molecular Weight	661.9994
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=C(I)C(C(=O)N(CCC(O)=O)C2=CC=CC=C2)=C(I)C=C1I

InChI

InChIKey=FJYJNLIEGUTPIJ-UHFFFAOYSA-N

InChI=1S/C16H13I3N2O3/c17-10-8-11(18)15(20)14(19)13(10)16(24)21(7-6-12(22)23)9-4-2-1-3-5-9/h1-5,8H,6-7,20H2,(H,22,23)

HIDE SMILES / InChI

Molecular Formula	C16H13I3N2O3
Molecular Weight	661.9994
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/14236022

Iobenzamic acid is a contrast medium, which was used for cholecystography under the name Osbil. It is assumed that the drug is no longer marketed.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Gallstones 4 Sources: http://www.ncbi.nlm.nih.gov/pubmed/14236022	Diagnostic		Approved 8583	OSBIL Approved Use Unknown

Doses

Dose	Population	Adverse events
500 mg single, oral Recommended Dose: 500 mg Route: oral Route: single Dose: 500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/14236022/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/14236022/	Other AEs: Nausea, Headache... Other AEs: Nausea (27%) Headache (18%) Vomiting (5%) Pain (6%) Sources: https://pubmed.ncbi.nlm.nih.gov/14236022/

AEs

AE	Significance	Dose	Population
Headache	18%	500 mg single, oral Recommended Dose: 500 mg Route: oral Route: single Dose: 500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/14236022/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/14236022/
Nausea	27%	500 mg single, oral Recommended Dose: 500 mg Route: oral Route: single Dose: 500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/14236022/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/14236022/
Vomiting	5%	500 mg single, oral Recommended Dose: 500 mg Route: oral Route: single Dose: 500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/14236022/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/14236022/
Pain	6%	500 mg single, oral Recommended Dose: 500 mg Route: oral Route: single Dose: 500 mg Sources: https://pubmed.ncbi.nlm.nih.gov/14236022/	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/14236022/

PubMed

Title	Date	PubMed
Effects of three-day oral cholecystography on serum iodothyronines and TSH concentrations: comparison of the effects among some cholecystographic agents and the effects of iopanoic acid on the pituitary-thyroid axis.	1979-11	517049
"OSBIL"--A CLINICAL TRIAL.	1965-07	14324895
[Experience with Osbil, a new oral biliary contrast medium].	1962-02-17	13893507
[Experience with Osbil, a contrast medium for oral cholecystography].	1962-02-11	13898724
[Osbil, a new oralbile contrast medium].	1962-01-12	14498496
[Osbil, a new contrast medium for oral cholangiocholecystography].	1961-07-07	13745243

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:44:55 GMT 2025` Edited by `admin` on `Mon Mar 31 18:44:55 GMT 2025`
Record UNII	F72UWG2SWK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IOBENZAMIC ACID

Official Name

English

OSBIL

Preferred Name

English

IOBENZAMIC ACID [MART.]

Common Name

English

IOBENZAMIC ACID [USAN]

Common Name

English

N-(3-Amino-2,4,6-triiodobenzoyl)-N-phenyl-?-alanine

Systematic Name

English

.BETA.-ALANINE, N-(3-AMINO-2,4,6-TRIIODOBENZOYL)-N-PHENYL-

Systematic Name

English

Iobenzamic acid [WHO-DD]

Common Name

English

iobenzamic acid [INN]

Common Name

English

IOBENZAMIC ACID [JAN]

Common Name

English

IOBENZAMIC ACID [MI]

Common Name

English

Classification Tree Code System Code

WHO-ATC

V08AC05