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Details

Stereochemistry ACHIRAL
Molecular Formula H2O3Se
Molecular Weight 128.97
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Selenious acid

SMILES

O[Se](O)=O

InChI

InChIKey=MCAHWIHFGHIESP-UHFFFAOYSA-N
InChI=1S/H2O3Se/c1-4(2)3/h(H2,1,2,3)

HIDE SMILES / InChI

Molecular Formula H2O3Se
Molecular Weight 128.97
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

The selenite anion is a selenium oxoanion with the chemical formula SeO2−3. A selenite (Se) is a compound that contains this ion. Sodium selenite is an inorganic form of the trace element selenium with potential antineoplastic activity. It was documented that Se deficiency observed in some countries and/or geographic regions (e.g. Keshan region in China), is associated with an increased morbidity and mortality of neoplastic diseases. To correct this problem a number of organic and inorganic selenium compounds were developed and tested. However, it is now firmly established that only an inorganic sodium selenite with four-valent Se, and not that with six-valent (selenate) cation shows anticancer activity. Selenite can undergo redox reaction, for example with protein's sulfhydryl groups expressed on the surface of tumor cells. In this way selenite prevents non-enzymatic formation of parafibrin that coats tumors cells and hence presents them as 'self' to the innate cellular immune system. Consequently, macrophages of the lymphatic system do not recognize neoplastic cells as 'foreign' bodies and spare them from the immune destruction. Sodium selenite also showed promise as a cost-effective, nontoxic anti-inflammatory agent. Treatment with sodium selenite lowers reactive oxygen species (ROS) production, causes a spontaneous reduction in lymphedema volume, increases the efficacy of physical therapy for lymphedema, and reduces the incidence of erysipelas infections in patients with chronic lymphedema. Limited evidence has been presented though that intakes of selenium greater than the amount needed to allow full expression of selenoproteins may have chemopreventive effects against cancer. Controlled intervention studies are needed to fully evaluate selenium as a cancer chemopreventive agent. The US Food and Drug Administration approved a selenium supplement to animal diets; the most common form is sodium selenite for pet foods.

Approval Year

Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
9.5 μM
4.5 mg/m² single, intravenous
dose: 4.5 mg/m²
route of administration: Intravenous
experiment type: SINGLE
co-administered:
SELENITE ION plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
200 μM × h
4.5 mg/m² single, intravenous
dose: 4.5 mg/m²
route of administration: Intravenous
experiment type: SINGLE
co-administered:
SELENITE ION plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
18.25 h
4.5 mg/m² single, intravenous
dose: 4.5 mg/m²
route of administration: Intravenous
experiment type: SINGLE
co-administered:
SELENITE ION plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
1 mg 1 times / day multiple, intravenous
Highest studied dose
Dose: 1 mg, 1 times / day
Route: intravenous
Route: multiple
Dose: 1 mg, 1 times / day
Sources:
unhealthy, adult
n = 296
Health Status: unhealthy
Condition: severe sepsis
Age Group: adult
Sex: M+F
Population Size: 296
Sources:
Other AEs: Respiratory failure...
AEs

AEs

AESignificanceDosePopulation
Respiratory failure grade 5
1 mg 1 times / day multiple, intravenous
Highest studied dose
Dose: 1 mg, 1 times / day
Route: intravenous
Route: multiple
Dose: 1 mg, 1 times / day
Sources:
unhealthy, adult
n = 296
Health Status: unhealthy
Condition: severe sepsis
Age Group: adult
Sex: M+F
Population Size: 296
Sources:
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

Extradietary supplementation of selenium at the dosage of 200 micrograms per day is generally considered safe and adequate for an adult of average weight subsisting on the typical American diet.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:14:19 GMT 2023
Edited
by admin
on Fri Dec 15 17:14:19 GMT 2023
Record UNII
F6A27P4Q4R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Selenious acid
HSDB   MART.   MI   USP   VANDF   WHO-DD  
Systematic Name English
SELENIUM (AS SELENIOUS ACID) [VANDF]
Common Name English
MONOHYDRATED SELENIUM DIOXIDE
Common Name English
HYDROGEN SELENITE
Systematic Name English
SELENIOUS ACID [ORANGE BOOK]
Common Name English
SELENIOUS ACID [HSDB]
Common Name English
SELENIOUS ACID [MI]
Common Name English
SELENOUS ACID
Systematic Name English
SELENIOUS ACID [VANDF]
Common Name English
SELENIOUS ACID [USP MONOGRAPH]
Common Name English
SELENIOUS ACID [MART.]
Common Name English
UN-3283
Code English
UN 3283
Code English
Selenious acid [WHO-DD]
Common Name English
SELENIUM DIOXIDE, MONOHYDRATED
Common Name English
Code System Code Type Description
FDA UNII
F6A27P4Q4R
Created by admin on Fri Dec 15 17:14:19 GMT 2023 , Edited by admin on Fri Dec 15 17:14:19 GMT 2023
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Fri Dec 15 17:14:20 GMT 2023 , Edited by admin on Fri Dec 15 17:14:20 GMT 2023
CONCEPT Dietary Supplement
ECHA (EC/EINECS)
231-974-7
Created by admin on Fri Dec 15 17:14:19 GMT 2023 , Edited by admin on Fri Dec 15 17:14:19 GMT 2023
PRIMARY
RXCUI
36344
Created by admin on Fri Dec 15 17:14:20 GMT 2023 , Edited by admin on Fri Dec 15 17:14:20 GMT 2023
PRIMARY RxNorm
WIKIPEDIA
SELENOUS ACID
Created by admin on Fri Dec 15 17:14:20 GMT 2023 , Edited by admin on Fri Dec 15 17:14:20 GMT 2023
PRIMARY
PUBCHEM
1091
Created by admin on Fri Dec 15 17:14:20 GMT 2023 , Edited by admin on Fri Dec 15 17:14:20 GMT 2023
PRIMARY
MESH
D020887
Created by admin on Fri Dec 15 17:14:20 GMT 2023 , Edited by admin on Fri Dec 15 17:14:20 GMT 2023
PRIMARY
EVMPD
SUB12574MIG
Created by admin on Fri Dec 15 17:14:19 GMT 2023 , Edited by admin on Fri Dec 15 17:14:19 GMT 2023
PRIMARY
CAS
7783-00-8
Created by admin on Fri Dec 15 17:14:19 GMT 2023 , Edited by admin on Fri Dec 15 17:14:19 GMT 2023
PRIMARY
HSDB
6065
Created by admin on Fri Dec 15 17:14:19 GMT 2023 , Edited by admin on Fri Dec 15 17:14:19 GMT 2023
PRIMARY
DRUG BANK
DB11127
Created by admin on Fri Dec 15 17:14:19 GMT 2023 , Edited by admin on Fri Dec 15 17:14:19 GMT 2023
PRIMARY
SMS_ID
100000078522
Created by admin on Fri Dec 15 17:14:20 GMT 2023 , Edited by admin on Fri Dec 15 17:14:20 GMT 2023
PRIMARY
CHEBI
29924
Created by admin on Fri Dec 15 17:14:19 GMT 2023 , Edited by admin on Fri Dec 15 17:14:19 GMT 2023
PRIMARY
NCI_THESAURUS
C87344
Created by admin on Fri Dec 15 17:14:20 GMT 2023 , Edited by admin on Fri Dec 15 17:14:20 GMT 2023
PRIMARY
EPA CompTox
DTXSID9024300
Created by admin on Fri Dec 15 17:14:19 GMT 2023 , Edited by admin on Fri Dec 15 17:14:19 GMT 2023
PRIMARY
MERCK INDEX
m9837
Created by admin on Fri Dec 15 17:14:20 GMT 2023 , Edited by admin on Fri Dec 15 17:14:20 GMT 2023
PRIMARY Merck Index
DAILYMED
F6A27P4Q4R
Created by admin on Fri Dec 15 17:14:19 GMT 2023 , Edited by admin on Fri Dec 15 17:14:19 GMT 2023
PRIMARY
CHEBI
26642
Created by admin on Fri Dec 15 17:14:19 GMT 2023 , Edited by admin on Fri Dec 15 17:14:19 GMT 2023
PRIMARY
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