Details
Stereochemistry | ACHIRAL |
Molecular Formula | C10H12ClNO |
Molecular Weight | 197.661 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
ClCCC(=O)NCC1=CC=CC=C1
InChI
InChIKey=JPYQFYIEOUVJDU-UHFFFAOYSA-N
InChI=1S/C10H12ClNO/c11-7-6-10(13)12-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,12,13)
Molecular Formula | C10H12ClNO |
Molecular Weight | 197.661 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Beclamide (N-benzyl-B-chloropropionamide) is a drug that possesses anticonvulsant activity. It is no longer used. It has been used as a sedative and as an anticonvulsant. Beclamide has been used in the management of both epilepsy and behavioral disorders associated with epilepsy. It was introduced into clinical practice in 1952 under the brand names Hibicon, Lederle and later it was withdrawn. This agent was shown to be effective in grand mal but not absence seizures. Early claims emphasized its safety, and it is not entirely clear why it was withdrawn from therapy for epilepsy. Interest in the drug was rekindled in the 1990s as an adjunct in the treatment of schizophrenia.
Approval Year
Cmax
Value | Dose | Co-administered | Analyte | Population |
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11 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1233999/ |
1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered: |
BECLAMIDE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
59 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1233999/ |
1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered: |
BECLAMIDE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1233999/ |
1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered: |
BECLAMIDE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
50% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1233999/ |
1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered: |
BECLAMIDE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Sample Use Guides
Adult Dosage: 7.14 to 14.28 mg/kg, p.o, Frequency - 8 hourly
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9890792
Succinic semialdehyde dehydrogenase activity was inhibited by 10 to 20% at low concentrations (0.01 to 0.1 mM) of diazepam, carbamazepine, beclamide, acetazolamide, and di-n-propylacetate, and by 40% or more at high concentrations (2.5 to 10.0 mM) of diazepam, phenobarbital, carbamazepine, Beclamide, and di-n-propylacetate in mouse brain homogenates. Beclamide at 100 umol/l significantly inhibited K+-evoked release of D-aspartate.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 16 16:56:53 UTC 2022
by
admin
on
Fri Dec 16 16:56:53 UTC 2022
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Record UNII |
F5N0ALI65V
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Record Status |
Validated (UNII)
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Record Version |
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WHO-ATC |
N03AX30
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WHO-VATC |
QN03AX30
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NCI_THESAURUS |
C264
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Code System | Code | Type | Description | ||
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CHEMBL64195
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M2286
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207-927-1
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501-68-8
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291
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10391
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823
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F5N0ALI65V
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18846
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PRIMARY | RxNorm | ||
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DTXSID5057755
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C011676
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BECLAMIDE
Created by
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C75160
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67062
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DB09011
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SUB05675MIG
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Related Record | Type | Details | ||
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ACTIVE MOIETY |