SAFRAZINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H16N2O2
Molecular Weight	208.2569
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CCC1=CC=C2OCOC2=C1)NN

InChI

InChIKey=IBWPUTAKVGZXRB-UHFFFAOYSA-N

InChI=1S/C11H16N2O2/c1-8(13-12)2-3-9-4-5-10-11(6-9)15-7-14-10/h4-6,8,13H,2-3,7,12H2,1H3

HIDE SMILES / InChI

Molecular Formula	C11H16N2O2
Molecular Weight	208.2569
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.drugbank.ca/drugs/DB09253 | https://www.ncbi.nlm.nih.gov/pubmed/8741286 | https://www.ncbi.nlm.nih.gov/pubmed/3339341

Safrazine (Safra) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was introduced as an antidepressant in the 1960s. Safrazine and electroconvulsive therapy were shown to be effective in the treatment of antidepressant-resistant depressions (ARD) but had the drawbacks of the high incidence of moderate or severe adverse reactions and high relapse rates, respectively. The use of safrazine was discontinued.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Monoamine oxidase 32 Target ID: CHEMBL2095205 Sources: https://www.ncbi.nlm.nih.gov/pubmed/477139	Inhibitor 8297

PubMed

Title	Date	PubMed
Comparative studies of the effects of RS-8359 and safrazine on monoamine oxidase in-vitro and in-vivo in mouse brain.	1989 Jan	2565961

Sample Use Guides

In Vivo Use Guide

Nocturnal periodic hypoxemia occurring in a 25-year-old Duchenne muscular dystrophy patient under NIPPV control was successfully treated with monoamine oxydase inhibitor (MAOI), safrazine hydrochloride. Five mg of safrazine hydrochloride was administered before sleep, and the periodic hypoxemia disappeared within 14 days.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:17:21 GMT 2023` Edited by `admin` on `Fri Dec 15 17:17:21 GMT 2023`
Record UNII	F5G0P5378C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SAFRAZINE

Common Name

English

Safrazine [WHO-DD]

Common Name

English

SAPHRAZINE, (±)-

Common Name

English

(±)-SAPHRAZINE

Common Name

English

SAPHRAZINE

Common Name

English

.BETA.-PIPERONYLISOPROPYLHYDRAZINE

Common Name

English

HYDRAZINE, (1-METHYL-3-(3,4-(METHYLENEDIOXY)PHENYL)PROPYL)

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C667