SPHINGOSINE 1-PHOSPHATE RECEPTOR 3

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 02:27:51 GMT 2025` Edited by `admin` on `Wed Apr 02 02:27:51 GMT 2025`
Protein Type	RECEPTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	F5D2GQ34MY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ENDOTHELIAL DIFFERENTIATION G-PROTEIN COUPLED RECEPTOR 3

Preferred Name

English

SPHINGOSINE 1-PHOSPHATE RECEPTOR 3

Common Name

English

S1P3

Common Name

English

S1P RECEPTOR EDG-3

Common Name

English

S1P RECEPTOR 3

Common Name

English

S1PR3

Common Name

English

SPHINGOSINE 1-PHOSPHATE RECEPTOR EDG-3

Common Name

English

Code System Code Type Description

UNIPROT

Q99500

Created by admin on Wed Apr 02 02:27:51 GMT 2025 , Edited by admin on Wed Apr 02 02:27:51 GMT 2025

PRIMARY

FDA UNII

F5D2GQ34MY

Created by admin on Wed Apr 02 02:27:51 GMT 2025 , Edited by admin on Wed Apr 02 02:27:51 GMT 2025

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_15

Related Record Type Details


					YVE187NJ1U

SPHINGOSINE 1-PHOSPHATE

AGONIST -> TARGET

Qualification:

EC50

Amount:


					Y333RS1786

CENERIMOD

AGONIST->OFF-TARGET

Comments:

Chinese Hamster Ovary (CHO) cells, overexpressing human S1P3 receptor (35S)-GTP-S incorporation assays.

Qualification:

EC50

Amount:


					92YDM6122J

FINGOLIMOD PHOSPHATE ESTER, (S)-

AGONIST -> TARGET

Comments:

Phase2 clinical trial results of siponimod and ceralifimod suggest that S1P3 and S1P4 targeting are not needed for therapeutic efficacy.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_326]	SITE_SPECIFIC			DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL