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Details

Stereochemistry MIXED
Molecular Formula C16H29NO5
Molecular Weight 315.4052
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BUTOCTAMIDE SEMISUCCINATE

SMILES

CCCCC(CC)CNC(=O)CC(C)OC(=O)CCC(O)=O

InChI

InChIKey=CQONVBIGUJWUFE-UHFFFAOYSA-N
InChI=1S/C16H29NO5/c1-4-6-7-13(5-2)11-17-14(18)10-12(3)22-16(21)9-8-15(19)20/h12-13H,4-11H2,1-3H3,(H,17,18)(H,19,20)

HIDE SMILES / InChI
Molecular Formula C16H29NO5
Molecular Weight 315.4052
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/7604145 and http://www.ncbi.nlm.nih.gov/pubmed/6813899

Butoctamide (Butoctamide hydrogen succinate, BAHS), which is related to an organic compound naturally occurring in CSF, has been demonstrated to increase REM sleep in cats and young adults. BAHS was confirmed also to increase REM sleep in healthy aged subjects. The drug is marketed under the brand named Listomin S in Japan. It is effective against insomnia and other sleep disorders.

CNS Activity

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Listomin

Approved Use

Hypnotics and sedatives
PubMed

PubMed

TitleDatePubMed
Release of serotonin from mast cells induced by N-(2-ethylhexyl)-3-hydroxybutyramide and catecholamine.
1977 Feb 1
Patents

Patents

US20140154313
3
US20150064250
2

Sample Use Guides

In Vivo Use Guide
three capsules (600mg) at night
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:00:53 GMT 2023
Edited
by admin
on Fri Dec 15 19:00:53 GMT 2023
Record UNII
F58251NT6M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BUTOCTAMIDE SEMISUCCINATE
JAN  
Common Name English
BUTOCTAMIDE HEMISUCCINATE
Common Name English
BUTOCTAMIDE SEMISUCCINATE [JAN]
Common Name English
Butoctamide succinate [WHO-DD]
Common Name English
BUTOCTAMIDE HYDROGEN SUCCINATE [MI]
Common Name English
BUTANEDIOIC ACID, 1-(3-((2-ETHYLHEXYL)AMINO)-1-METHYL-3-OXOPROPYL) ESTER
Common Name English
BUTOCTAMIDE SUCCINATE
WHO-DD  
Common Name English
Code System Code Type Description
ChEMBL
CHEMBL452859
Created by admin on Fri Dec 15 19:00:53 GMT 2023 , Edited by admin on Fri Dec 15 19:00:53 GMT 2023
PRIMARY
EPA CompTox
DTXSID4057716
Created by admin on Fri Dec 15 19:00:53 GMT 2023 , Edited by admin on Fri Dec 15 19:00:53 GMT 2023
PRIMARY
MERCK INDEX
m606
Created by admin on Fri Dec 15 19:00:53 GMT 2023 , Edited by admin on Fri Dec 15 19:00:53 GMT 2023
PRIMARY Merck Index
SMS_ID
100000128438
Created by admin on Fri Dec 15 19:00:53 GMT 2023 , Edited by admin on Fri Dec 15 19:00:53 GMT 2023
PRIMARY
CAS
32838-28-1
Created by admin on Fri Dec 15 19:00:53 GMT 2023 , Edited by admin on Fri Dec 15 19:00:53 GMT 2023
PRIMARY
PUBCHEM
2486
Created by admin on Fri Dec 15 19:00:53 GMT 2023 , Edited by admin on Fri Dec 15 19:00:53 GMT 2023
PRIMARY
EVMPD
SUB35473
Created by admin on Fri Dec 15 19:00:53 GMT 2023 , Edited by admin on Fri Dec 15 19:00:53 GMT 2023
PRIMARY
FDA UNII
F58251NT6M
Created by admin on Fri Dec 15 19:00:53 GMT 2023 , Edited by admin on Fri Dec 15 19:00:53 GMT 2023
PRIMARY
EVMPD
SUB00919MIG
Created by admin on Fri Dec 15 19:00:53 GMT 2023 , Edited by admin on Fri Dec 15 19:00:53 GMT 2023
PRIMARY
Related Record Type Details
Structure of BUTOCTAMIDE
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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