BUTOCTAMIDE

Details

Stereochemistry	MIXED
Molecular Formula	C12H25NO2
Molecular Weight	215.3324
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC(CC)CNC(=O)CC(C)O

InChI

InChIKey=WTBQLHRVRKXSPX-UHFFFAOYSA-N

InChI=1S/C12H25NO2/c1-4-6-7-11(5-2)9-13-12(15)8-10(3)14/h10-11,14H,4-9H2,1-3H3,(H,13,15)

HIDE SMILES / InChI

Molecular Formula	C12H25NO2
Molecular Weight	215.3324
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/7624490
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/7604145 and http://www.ncbi.nlm.nih.gov/pubmed/6813899

Butoctamide (Butoctamide hydrogen succinate, BAHS), which is related to an organic compound naturally occurring in CSF, has been demonstrated to increase REM sleep in cats and young adults. BAHS was confirmed also to increase REM sleep in healthy aged subjects. The drug is marketed under the brand named Listomin S in Japan. It is effective against insomnia and other sleep disorders.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
serotonin secretion 8 Target ID: GO:0001820 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6813899	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Insomnia 108 Sources: http://www.ncbi.nlm.nih.gov/pubmed/7624490	Primary		Approved 8429	Listomin Approved Use Hypnotics and sedatives

PubMed

Title	Date	PubMed
Release of serotonin from mast cells induced by N-(2-ethylhexyl)-3-hydroxybutyramide and catecholamine.	1977 Feb 1	66055

Patents

Sample Use Guides

In Vivo Use Guide

three capsules (600mg) at night

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:01:09 GMT 2023` Edited by `admin` on `Fri Dec 15 16:01:09 GMT 2023`
Record UNII	6MDC25LQSR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BUTOCTAMIDE

Official Name

English

Butoctamide [WHO-DD]

Common Name

English

BUTOCTAMIDE [JAN]

Common Name

English

butoctamide [INN]

Common Name

English

BUTOCTAMIDE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29756