U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C19H30N5O10P
Molecular Weight 519.4428
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TENOFOVIR DISOPROXIL

SMILES

CC(C)OC(=O)OCOP(=O)(CO[C@H](C)CN1C=NC2=C1N=CN=C2N)OCOC(=O)OC(C)C

InChI

InChIKey=JFVZFKDSXNQEJW-CQSZACIVSA-N
InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1

HIDE SMILES / InChI
Molecular Formula C19H30N5O10P
Molecular Weight 519.4428
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/9765248 | http://www.sciencedirect.com/science/article/pii/S2211383512001402

(R)-9-(2-Phosphonylmethoxypropyl)adenine (PMPA known as tenofovir) is an antiviral drug. Diphosphate of PMPA acts as a selective inhibitor of the HIV-1 reverse transcriptase. Tenofovir disoproxil was approved for clinical use for the treatment of HIV infection (AIDS) and chronic HBV infection.

CNS Activity

Originator

Balzarini, J. et al.
22
Curator's Comment: reference retrieved from http://www.sciencedirect.com/science/article/pii/S2211383512001402

Approval Year

2001
187
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8504
 58.0 µM [Kd]
Inhibitor
8504
 3.3 nM [EC50]
Inhibitor
8504
 3.5 nM [EC50]
Inhibitor
8504
 0.49 µM [EC50]
Inhibitor
8504
 0.3 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
VIREAD

Approved Use

Tenofovir disoproxil fumarate is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV and HBV infections

Launch Date

2012
Primary
Approved
8583
VIREAD

Approved Use

Tenofovir disoproxil fumarate is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV and HBV infections

Launch Date

2012
Primary
Phase II
1147
Unknown

Approved Use

Unknown
Primary
Basic research
Unknown

Approved Use

Unknown
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
209.6 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
150 mg single, oral
dose: 150 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
456.7 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
300 mg single, oral
dose: 300 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
448.5 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
300 mg single, oral
dose: 300 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
989.8 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
600 mg single, oral
dose: 600 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
523.4 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
300 mg 1 times / day multiple, oral
dose: 300 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
0.03 μg/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208464s000lbl.pdf
25 mg 1 times / day multiple, oral
dose: 25 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
326 ng/mL
OTHER
https://www.medicines.org.uk/emc/product/8138/smpc#PRODUCTINFO
245 mg 1 times / day multiple, oral
dose: 245 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TENOFOVIR serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
2079.1 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
150 mg single, oral
dose: 150 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
3006.1 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
300 mg single, oral
dose: 300 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
3408.2 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
300 mg single, oral
dose: 300 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
6373.9 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
600 mg single, oral
dose: 600 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
4476.7 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
300 mg 1 times / day multiple, oral
dose: 300 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
0.4 μg × h/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208464s000lbl.pdf
25 mg 1 times / day multiple, oral
dose: 25 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
3324 ng × h/mL
OTHER
https://www.medicines.org.uk/emc/product/8138/smpc#PRODUCTINFO
245 mg 1 times / day multiple, oral
dose: 245 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TENOFOVIR serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
18.54 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
150 mg single, oral
dose: 150 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
17.56 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
300 mg single, oral
dose: 300 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
16.86 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
300 mg single, oral
dose: 300 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
18.92 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
600 mg single, oral
dose: 600 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
17.12 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/23278367
300 mg 1 times / day multiple, oral
dose: 300 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TENOFOVIR plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
18 h
OTHER
https://www.medicines.org.uk/emc/product/8138/smpc#PRODUCTINFO
245 mg 1 times / day multiple, oral
dose: 245 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TENOFOVIR serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
99.3%
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021356s042,022577s002lbl.pdf
TENOFOVIR plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
99.3%
OTHER
https://www.medicines.org.uk/emc/product/8138/smpc#PRODUCTINFO
245 mg 1 times / day multiple, oral
dose: 245 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TENOFOVIR serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
Sourcing

Sourcing

Vendor/AggregatorIDURL
3B Scientific (Wuhan) Corp
3B2-0205
http://www.3bsc.com/index/pro_info.php?id=19561
AA Blocks
AA001EJQ
http://www.aablocks.com/goods/Goods/detail?id=AA001EJQ
Aaron Chemicals
AR001FBI
http://www.aaronchem.com/147127-20-6
abcr GmbH
AB437841
http://www.abcr.com/shop/en/AB437841
AbMole Bioscience
M5051
http://www.abmole.com/products/tenofovir.html
Acorn PharmaTech
ACN-029240
http://www.acornpharmatech.com/
Active Biopharma
ABP000917
http://www.activebiopharma.com/147127-20-6
Adooq BioScience
A10908
https://www.adooq.com/tenofovir-viread.html
AEchem Scientific Corp., USA
AE1-016163
http://www.aechemsc.com/info_products/AE1-016163.php
AHH Chemical co.,ltd
API-1191
http://www.ahhchemical.com/product/API-1191.html
AK Scientific, Inc. (AKSCI)
J90012
http://www.aksci.com/item_detail.php?cat=J90012
Alsachim
1763
http://www.alsachim.com/product-C2530-glo.bal-view.html
Angene
AGN-PC-0PZUPY
http://www.angenechemical.com/productshow/AGN-PC-0PZUPY.html
ApexBio Technology
A5275
http://www.apexbt.com/tenofovir.html
AstaTech, Inc.
34244
http://www.astatechinc.com/CPSResult.php?CRNO=35657
Aurum Pharmatech LLC
S-2389
http://www.Aurumpharmatech.com/Product/ProductDetails/S_2389
AvaChem Scientific
2678
http://www.avachem.com/productSearch.asp?2678
Axon MedChem
3157
https://www.axonmedchem.com/product/3157
BioCrick
BCC2500
http://www.biocrick.com/Tenofovir-BCC2500.html
BioSynth
Q-201787
https://www.biosynth.com/en/products/life-science/enzyme-substrates-reagents/products/Q-201787.html
BLD Pharm
BD01204701
http://www.bldpharm.com/products/107021-12-5.html
BLD Pharm
BD18435
http://www.bldpharm.com/products/147127-20-6.html
Boerchem
BC208449
http://www.boerchem.com/?product_35256.html
Capot Chemical
9452
http://www.capotchem.com/en/9452.htm
Capot Chemical
PubChem9452
http://www.capotchem.com/en/9452.htm
Chem Scene
CS-1609
http://www.chemscene.com/147127-20-6.html
Chemenu
CM110444
http://www.chemenu.com/products/CM110444
ChemMol
1032196
http://www.chemmol.com/chemmol/1032196.html
ChemMol
30108887
http://www.chemmol.com/chemmol/30108887.html
ChemMol
44003255
http://www.chemmol.com/chemmol/44003255.html
ChemMol
97900713
http://www.chemmol.com/chemmol/97900713.html
ChemReagents
80014913
http://www.chemreagents.com/Product/Product.asp?ProductID=80014913
Chemspace
CSSB00016987604
https://chem-space.com/CSSB00016987604
Chiralblock Biosciences
CB10985
http://www.chiralblock.com/products/147127-20-6.html
CSNpharm
CSN12559
https://www.csnpharm.com/products/tenofovir.html
eNovation Chemicals
D275770
https://www.enovationchem.com/ProductDetails.asp?ProductID=D275770
eNovation Chemicals
D320167
http://www.enovationchem.com/productDetails.asp?productID=D320167
iChemical
EBD47973
http://www.ichemical.com/products/147127-20-6.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
Matrix Scientific
74030
https://www.matrixscientific.com/074030.html
MedChem Express
HY-13910
https://www.medchemexpress.com/tenofovir.html
Oakwood
77792
http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=62966&ExtHyperLink=1
OChem
5252
http://www.ocheminc.com/index.php?act=psearch&pid=127T206
Selleck Chemicals
S1401
http://www.selleckchem.com/products/Tenofovir.html
Sigma-Aldrich
SML1795_SIGMA
https://www.sigmaaldrich.com/catalog/product/sigma/sml1795?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule
S544915
http://www.smolecule.com/products/s544915
Smolecule
S752291
https://www.smolecule.com/products/s752291
TCI (Tokyo Chemical Industry)
T3006
http://www.tcichemicals.com/eshop/en/us/commodity/T3006/index.html
THE BioTek
bt-284194
https://www.thebiotek.com/product/inhibitors/bt-284194
THE BioTek
bt-293647
https://www.thebiotek.com/product/others/bt-293647
Tocris
3666
https://www.tocris.com/products/tenofovir_3666
Yuhao Chemical
A0500092
http://www.chemyuhao.com/147127-20-6.html
PubMed

PubMed

TitleDatePubMed
Development of hexadecyloxypropyl tenofovir (CMX157) for treatment of infection caused by wild-type and nucleoside/nucleotide-resistant HIV.
2010-07
Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-Phosphonylmethoxypropyl)adenine.
1998-10-16
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine.
1993-02
Patents

Patents

20080103115
22
20110021464
22
EP2440560
22
JP2011506374A
22

Sample Use Guides

In Vivo Use Guide
For hepatitis B - 5-100mg tablet
Route of Administration: Oral
In Vitro Use Guide
CMX-157 was active against all major subtypes of HIV-1 and HIV-2 in fresh human peripheral blood mononuclear cells (PBMCs) and against all HIV-1 strains evaluated in monocyte-derived macrophages, with 50% effective concentrations (EC(50)s) ranging between 0.20 and 7.2 nM.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:07:34 GMT 2025
Edited
by admin
on Mon Mar 31 18:07:34 GMT 2025
Record UNII
F4YU4LON7I
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TENOFOVIR BIS(ISOPROPYLOXYCARBONYLOXYMETHYL) ESTER
MI  
Preferred Name English
TENOFOVIR DISOPROXIL
EMA EPAR   WHO-DD  
Common Name English
GS-4331
Code English
TENOFOVIR BIS(ISOPROPYLOXYCARBONYLOXYMETHYL) ESTER [MI]
Common Name English
TENOFOVIR DISOPROXIL [EMA EPAR]
Common Name English
STRIBILD COMPONENT TENOFOVIR DISOPROXIL
Brand Name English
BIS-POC-PMPA
Common Name English
(R)-BIS(POC)PMPA
Common Name English
Tenofovir disoproxil [WHO-DD]
Common Name English
2,4,6,8-TETRAOXA-5-PHOSPHANONANEDIOIC ACID, 5-(((1R)-2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY)METHYL)-, 1,9-BIS(1-METHYLETHYL) ESTER, 5-OXIDE
Systematic Name English
Classification Tree Code System Code
WHO-VATC QJ05AR09
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
EMA ASSESSMENT REPORTS STRIBILD (AUTHORIZED: HIV INFECTIONS)
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-ATC J05AR24
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-ATC J05AR09
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-ATC J05AR12
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-ATC J05AF07
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-VATC QJ05AR11
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-ATC J05AR11
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-VATC QJ05AR06
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-ATC J05AR06
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-ATC J05AR08
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-VATC QJ05AR03
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-ATC J05AR03
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-VATC QJ05AF07
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
WHO-VATC QJ05AR08
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
Code System Code Type Description
DRUG BANK
DB00300
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
DRUG CENTRAL
2593
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
MESH
C418563
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
EVMPD
SUB20643
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
SMS_ID
100000088017
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
WIKIPEDIA
Tenofovir disoproxil
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
PUBCHEM
5481350
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
EPA CompTox
DTXSID5052757
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
CAS
201341-05-1
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
MERCK INDEX
m10559
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY Merck Index
FDA UNII
F4YU4LON7I
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
RXCUI
300195
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY RxNorm
CHEBI
63717
Created by admin on Mon Mar 31 18:07:34 GMT 2025 , Edited by admin on Mon Mar 31 18:07:34 GMT 2025
PRIMARY
Related Record Type Details
Structure of TENOFOVIR DISOPROXIL OROTATE
SALT/SOLVATE -> PARENT
Structure of Tenofovir disoproxil hemiedisylate
SALT/SOLVATE -> PARENT
Structure of TENOFOVIR DISOPROXIL ASPARTATE
SALT/SOLVATE -> PARENT
Structure of TENOFOVIR DISOPROXIL MALEATE
SALT/SOLVATE -> PARENT
Structure of TENOFOVIR DISOPROXIL PHOSPHATE
SALT/SOLVATE -> PARENT
Structure of TENOFOVIR DISOPROXIL SUCCINATE
SALT/SOLVATE -> PARENT
Structure of TENOFOVIR DISOPROXIL FUMARATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of TENOFOVIR ANHYDROUS
METABOLITE ACTIVE -> PRODRUG
Related Record Type Details
Structure of TENOFOVIR ANHYDROUS
ACTIVE MOIETY
NIH
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