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Details

Stereochemistry RACEMIC
Molecular Formula C8H12N2.H2O4S
Molecular Weight 234.273
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEBANAZINE SULFATE

SMILES

OS(O)(=O)=O.CC(NN)C1=CC=CC=C1

InChI

InChIKey=XTODHAAOYCGVIW-UHFFFAOYSA-N
InChI=1S/C8H12N2.H2O4S/c1-7(10-9)8-5-3-2-4-6-8;1-5(2,3)4/h2-7,10H,9H2,1H3;(H2,1,2,3,4)

HIDE SMILES / InChI

Molecular Formula H2O4S
Molecular Weight 98.078
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C8H12N2
Molecular Weight 136.1943
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Mebanazine is an inhibitor of monoamine oxidase. It was introduced in the 1960s for the treatment of depression and was marketed under trade name Actomol. The drug was withdrawn from the market due to hepatotoxicity. In addition to its antidepressant effect, the drug was found to possess an anorexic action and in animal models, it potentiated the hypoglycemic response to insulin and delayed the recovery of blood glucose levels to normal.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
A controlled trial of mebanazine ('Actomol') in depression.
1965 Nov
A preliminary trial of mebanazine in depressive states.
1965 Nov-Dec
Clinical trial of mebanazine--a new monoamine oxidase inhibitor.
1965 Sep
Substance Class Chemical
Created
by admin
on Sat Dec 16 09:53:20 GMT 2023
Edited
by admin
on Sat Dec 16 09:53:20 GMT 2023
Record UNII
F48WW53685
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MEBANAZINE SULFATE
Common Name English
MEBANAZINE SULPHATE
Common Name English
HYDRAZINE, (1-PHENYLETHYL)-, SULFATE (1:1)
Systematic Name English
Code System Code Type Description
PUBCHEM
19879
Created by admin on Sat Dec 16 09:53:20 GMT 2023 , Edited by admin on Sat Dec 16 09:53:20 GMT 2023
PRIMARY
EPA CompTox
DTXSID4048808
Created by admin on Sat Dec 16 09:53:20 GMT 2023 , Edited by admin on Sat Dec 16 09:53:20 GMT 2023
PRIMARY
CAS
3979-76-8
Created by admin on Sat Dec 16 09:53:20 GMT 2023 , Edited by admin on Sat Dec 16 09:53:20 GMT 2023
PRIMARY
FDA UNII
F48WW53685
Created by admin on Sat Dec 16 09:53:20 GMT 2023 , Edited by admin on Sat Dec 16 09:53:20 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY