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Details

Stereochemistry ACHIRAL
Molecular Formula C17H21NO.2C9H10N4O4
Molecular Weight 731.7549
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BIETANAUTINE

SMILES

CN1C2=C(N(CC(O)=O)C=N2)C(=O)N(C)C1=O.CN3C4=C(N(CC(O)=O)C=N4)C(=O)N(C)C3=O.CN(C)CCOC(C5=CC=CC=C5)C6=CC=CC=C6

InChI

InChIKey=COTYIKUDNNMSDT-UHFFFAOYSA-N
InChI=1S/C17H21NO.2C9H10N4O4/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;2*1-11-7-6(8(16)12(2)9(11)17)13(4-10-7)3-5(14)15/h3-12,17H,13-14H2,1-2H3;2*4H,3H2,1-2H3,(H,14,15)

HIDE SMILES / InChI

Molecular Formula C9H10N4O4
Molecular Weight 238.2001
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C17H21NO
Molecular Weight 255.3547
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Diphenhydramine is an antihistamine which is used in the combination with naproxen sodium for the relief of occasional sleeplessness when associated with minor aches and pains. Diphenhydramine has a role nighttime sleep-aid and naproxen sodium is a pain reliever. In addition, diphenhydramine used in relieving symptoms in patients with moderate-to-severe seasonal allergic rhinitis. Diphenhydramine acts as an antagonist of histamine H1 receptor. Besides, was shown potential to repurpose diphenhydramine as an anti-melanoma therapeutic agent, it induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling pathway.

CNS Activity

Originator

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Palliative
ALEVE PM
PubMed

PubMed

TitleDatePubMed
Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines).
1985 Nov-Dec
Diphenhydramine.
1986 Feb
Diphenhydramine: pharmacokinetics and pharmacodynamics in elderly adults, young adults, and children.
1990 Jul
Evaluation of diphenhydramine in talc induced type 2 diabetes mellitus in Wistar rats.
2018 Jan
A patient with anaphylaxis to diphenhydramine without cross-reactivity to loratadine.
2018 May - Jun
Patents

Patents

Sample Use Guides

In Vivo Use Guide
occasional sleeplessness: do not take more than directed; drink a full glass of water with each dose, adults and children 12 years and over: take 2 caplets at bedtime, do not take more than 2 caplets in 24 hours, if taken with food, this product may take longer to work
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Tue Oct 22 00:50:09 UTC 2019
Edited
by admin
on Tue Oct 22 00:50:09 UTC 2019
Record UNII
F3D8G86A29
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BIETANAUTINE
Common Name English
DIPHENHYDRAMINE DI(ACEFYLLINATE) [MI]
Common Name English
1,2,3,6-TETRAHYDRO-1,3-DIMETHYL-2,6-DIOXO-7H-PURINE-7-ACETIC ACID COMPD WITH 2-(DIPHENYLMETHOXY)-N,N-DIMETHYLETHANAMINE (2:1)
Common Name English
DIPHENHYDRAMINE ACEFYLLINATE
WHO-DD  
Common Name English
O-BENZHYDRYLDIMETHYLAMINOETHANOL BIS(THEOPHYLLINE 7-ACETATE)
Common Name English
NAUTAMINE
Brand Name English
DIPHENHYDRAMINE DI(ACEFYLLINATE) [MART.]
Common Name English
DIPHENHYDRAMINE ACEFYLLINATE [WHO-DD]
Common Name English
DIPHENHYDRAMINE DI(ACEFYLLINATE)
MART.   MI  
Common Name English
DIPHENHYDRAMINE DIACEFYLLINATE
Common Name English
Classification Tree Code System Code
WHO-ATC N04AB01
Created by admin on Tue Oct 22 00:50:09 UTC 2019 , Edited by admin on Tue Oct 22 00:50:09 UTC 2019
Code System Code Type Description
CAS
6888-11-5
Created by admin on Tue Oct 22 00:50:09 UTC 2019 , Edited by admin on Tue Oct 22 00:50:09 UTC 2019
PRIMARY
MERCK INDEX
M4609
Created by admin on Tue Oct 22 00:50:09 UTC 2019 , Edited by admin on Tue Oct 22 00:50:09 UTC 2019
PRIMARY Merck Index
EVMPD
SUB01767MIG
Created by admin on Tue Oct 22 00:50:09 UTC 2019 , Edited by admin on Tue Oct 22 00:50:09 UTC 2019
PRIMARY
PUBCHEM
11607326
Created by admin on Tue Oct 22 00:50:09 UTC 2019 , Edited by admin on Tue Oct 22 00:50:09 UTC 2019
PRIMARY
RXCUI
236260
Created by admin on Tue Oct 22 00:50:09 UTC 2019 , Edited by admin on Tue Oct 22 00:50:09 UTC 2019
PRIMARY RxNorm
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY
ACTIVE MOIETY