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US Approved OTC

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Primary Target

HERG

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Histamine H1 receptor

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Neuronal acetylcholine receptor protein alpha-7 subunit

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Highest Phase

Approved

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Approval Year

1946

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Condition

Occasional sleeplessness

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Seasonal allergic rhinitis

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Treatment Modality

Palliative

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CNS Activity

CNS Active

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Originator

Rieveschl, G.

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Chemical

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FDA UNII

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PUBCHEM

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EVMPD

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SMS_ID

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ATC Level 1

NERVOUS SYSTEM

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DERMATOLOGICALS

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ATC Level 2

ANTI-PARKINSON DRUGS

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ANTIHISTAMINES FOR SYSTEMIC USE

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ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.

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ATC Level 3

ANTICHOLINERGIC AGENTS

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ATC Level 4

Ethers chemically close to antihistamines

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Aminoalkyl ethers

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Antihistamines for topical use

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Showing 1 - 10 of 10 results

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DIPHENHYDRAMINE

8GTS82S83M

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Status:

US Approved OTC

First approved in 1946

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histamine H1 receptor

Neuronal acetylcholine receptor protein alpha-7 subunit

Histamine H1 receptor

Conditions:

Occasional sleeplessness

Seasonal allergic rhinitis

Diphenhydramine is an antihistamine which is used in the combination with naproxen sodium for the relief of occasional sleeplessness when associated with minor aches and pains. Diphenhydramine has a role nighttime sleep-aid and naproxen sodium is a p...

ain reliever. In addition, diphenhydramine used in relieving symptoms in patients with moderate-to-severe seasonal allergic rhinitis. Diphenhydramine acts as an antagonist of histamine H1 receptor. Besides, was shown potential to repurpose diphenhydramine as an anti-melanoma therapeutic agent, it induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling pathway.

ETANAUTINE

97H5S09M4T

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Status:

US Approved OTC

First approved in 1946

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histamine H1 receptor

Neuronal acetylcholine receptor protein alpha-7 subunit

Histamine H1 receptor

Conditions:

Occasional sleeplessness

Seasonal allergic rhinitis

Diphenhydramine is an antihistamine which is used in the combination with naproxen sodium for the relief of occasional sleeplessness when associated with minor aches and pains. Diphenhydramine has a role nighttime sleep-aid and naproxen sodium is a p...

ain reliever. In addition, diphenhydramine used in relieving symptoms in patients with moderate-to-severe seasonal allergic rhinitis. Diphenhydramine acts as an antagonist of histamine H1 receptor. Besides, was shown potential to repurpose diphenhydramine as an anti-melanoma therapeutic agent, it induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling pathway.

DIPHENHYDRAMINE CITRATE

4OD433S209

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Status:

US Approved OTC

First approved in 1946

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histamine H1 receptor

Neuronal acetylcholine receptor protein alpha-7 subunit

Histamine H1 receptor

Conditions:

Occasional sleeplessness

Seasonal allergic rhinitis

Diphenhydramine is an antihistamine which is used in the combination with naproxen sodium for the relief of occasional sleeplessness when associated with minor aches and pains. Diphenhydramine has a role nighttime sleep-aid and naproxen sodium is a p...

ain reliever. In addition, diphenhydramine used in relieving symptoms in patients with moderate-to-severe seasonal allergic rhinitis. Diphenhydramine acts as an antagonist of histamine H1 receptor. Besides, was shown potential to repurpose diphenhydramine as an anti-melanoma therapeutic agent, it induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling pathway.

DIPHENHYDRAMINE LAURYLSULFATE

3E2CN035LB

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Status:

US Approved OTC

First approved in 1946

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histamine H1 receptor

Neuronal acetylcholine receptor protein alpha-7 subunit

Histamine H1 receptor

Conditions:

Occasional sleeplessness

Seasonal allergic rhinitis

Diphenhydramine is an antihistamine which is used in the combination with naproxen sodium for the relief of occasional sleeplessness when associated with minor aches and pains. Diphenhydramine has a role nighttime sleep-aid and naproxen sodium is a p...

ain reliever. In addition, diphenhydramine used in relieving symptoms in patients with moderate-to-severe seasonal allergic rhinitis. Diphenhydramine acts as an antagonist of histamine H1 receptor. Besides, was shown potential to repurpose diphenhydramine as an anti-melanoma therapeutic agent, it induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling pathway.

DIPHENHYDRAMINE TANNATE

OPI52249ZG

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Status:

US Approved OTC

First approved in 1946

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Histamine H1 receptor

Neuronal acetylcholine receptor protein alpha-7 subunit

Histamine H1 receptor

Conditions:

Occasional sleeplessness

Seasonal allergic rhinitis

Diphenhydramine is an antihistamine which is used in the combination with naproxen sodium for the relief of occasional sleeplessness when associated with minor aches and pains. Diphenhydramine has a role nighttime sleep-aid and naproxen sodium is a p...

ain reliever. In addition, diphenhydramine used in relieving symptoms in patients with moderate-to-severe seasonal allergic rhinitis. Diphenhydramine acts as an antagonist of histamine H1 receptor. Besides, was shown potential to repurpose diphenhydramine as an anti-melanoma therapeutic agent, it induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling pathway.

BIETANAUTINE

F3D8G86A29

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Status:

US Approved OTC

First approved in 1946

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histamine H1 receptor

Neuronal acetylcholine receptor protein alpha-7 subunit

Histamine H1 receptor

Conditions:

Occasional sleeplessness

Seasonal allergic rhinitis

Diphenhydramine is an antihistamine which is used in the combination with naproxen sodium for the relief of occasional sleeplessness when associated with minor aches and pains. Diphenhydramine has a role nighttime sleep-aid and naproxen sodium is a p...

ain reliever. In addition, diphenhydramine used in relieving symptoms in patients with moderate-to-severe seasonal allergic rhinitis. Diphenhydramine acts as an antagonist of histamine H1 receptor. Besides, was shown potential to repurpose diphenhydramine as an anti-melanoma therapeutic agent, it induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling pathway.

DIPHENHYDRAMINE MALEATE

54A11R7E1Y

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Status:

US Approved OTC

First approved in 1946

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histamine H1 receptor

Neuronal acetylcholine receptor protein alpha-7 subunit

Histamine H1 receptor

Conditions:

Occasional sleeplessness

Seasonal allergic rhinitis

Diphenhydramine is an antihistamine which is used in the combination with naproxen sodium for the relief of occasional sleeplessness when associated with minor aches and pains. Diphenhydramine has a role nighttime sleep-aid and naproxen sodium is a p...

ain reliever. In addition, diphenhydramine used in relieving symptoms in patients with moderate-to-severe seasonal allergic rhinitis. Diphenhydramine acts as an antagonist of histamine H1 receptor. Besides, was shown potential to repurpose diphenhydramine as an anti-melanoma therapeutic agent, it induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling pathway.

DIPHENHYDRAMINE SALICYLATE

707L3YC54L

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Status:

US Approved OTC

First approved in 1946

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histamine H1 receptor

Neuronal acetylcholine receptor protein alpha-7 subunit

Histamine H1 receptor

Conditions:

Occasional sleeplessness

Seasonal allergic rhinitis

Diphenhydramine is an antihistamine which is used in the combination with naproxen sodium for the relief of occasional sleeplessness when associated with minor aches and pains. Diphenhydramine has a role nighttime sleep-aid and naproxen sodium is a p...

ain reliever. In addition, diphenhydramine used in relieving symptoms in patients with moderate-to-severe seasonal allergic rhinitis. Diphenhydramine acts as an antagonist of histamine H1 receptor. Besides, was shown potential to repurpose diphenhydramine as an anti-melanoma therapeutic agent, it induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling pathway.

DIMENHYDRINATE HYDROCHLORIDE

WWI80U0EMC

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Status:

US Approved OTC

First approved in 1946

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histamine H1 receptor

Neuronal acetylcholine receptor protein alpha-7 subunit

Histamine H1 receptor

Conditions:

Occasional sleeplessness

Seasonal allergic rhinitis

Diphenhydramine is an antihistamine which is used in the combination with naproxen sodium for the relief of occasional sleeplessness when associated with minor aches and pains. Diphenhydramine has a role nighttime sleep-aid and naproxen sodium is a p...

ain reliever. In addition, diphenhydramine used in relieving symptoms in patients with moderate-to-severe seasonal allergic rhinitis. Diphenhydramine acts as an antagonist of histamine H1 receptor. Besides, was shown potential to repurpose diphenhydramine as an anti-melanoma therapeutic agent, it induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling pathway.

DIPHENHYDRAMINE HYDROCHLORIDE

TC2D6JAD40

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Status:

US Approved OTC

First approved in 1946

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histamine H1 receptor

Neuronal acetylcholine receptor protein alpha-7 subunit

Histamine H1 receptor

Conditions:

Occasional sleeplessness

Seasonal allergic rhinitis

Diphenhydramine is an antihistamine which is used in the combination with naproxen sodium for the relief of occasional sleeplessness when associated with minor aches and pains. Diphenhydramine has a role nighttime sleep-aid and naproxen sodium is a p...

ain reliever. In addition, diphenhydramine used in relieving symptoms in patients with moderate-to-severe seasonal allergic rhinitis. Diphenhydramine acts as an antagonist of histamine H1 receptor. Besides, was shown potential to repurpose diphenhydramine as an anti-melanoma therapeutic agent, it induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling pathway.

HHS VULNERABILITY DISCLOSURE

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