U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C13H17N
Molecular Weight 188.2938
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of L-DEPRENYL-D2 C-11

SMILES

[2H]C([2H])(C#C)N([11CH3])[C@H](C)CC1=CC=CC=C1

InChI

InChIKey=MEZLKOACVSPNER-FDJJMKDCSA-N
InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m1/s1/i3-1,10D2

HIDE SMILES / InChI
Molecular Formula C13H17N
Molecular Weight 188.2938
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

L-DEPRENYL-D2 C-11 is a selective irreversible inhibitor of monoamine oxidase B (Mao-B) which labels functionally active enzyme. It is used as a positron emission tomography radioligand for measurement of the Mao-B activity in vivo brain.

CNS Activity

Originator

Approval Year

Unknown
134361
PubMed

PubMed

TitleDatePubMed
Mapping human brain monoamine oxidase A and B with 11C-labeled suicide inactivators and PET.
1987 Jan 23
Selective reduction of radiotracer trapping by deuterium substitution: comparison of carbon-11-L-deprenyl and carbon-11-deprenyl-D2 for MAO B mapping.
1995 Jul
Test-retest reproducibility of [(11)C]-L-deprenyl-D(2) binding to MAO-B in the human brain.
2017 Dec
Substance Class Chemical
Created
by admin
on Thu Jul 06 13:20:46 UTC 2023
Edited
by admin
on Thu Jul 06 13:20:46 UTC 2023
Record UNII
F2796O8AEN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
L-DEPRENYL-D2 C-11
Common Name English
C11-DED
Common Name English
(11C)L-DEPRENYL-D2
Common Name English
BENZENEETHANAMINE, .ALPHA.-METHYL-N-(METHYL-11C)-N-(2-PROPYNYL-1,1-D2)-, (.ALPHA.R)-
Systematic Name English
11C-L-SELEGILINE-D2
Common Name English
11C-L-DEPRENYL-D2
Common Name English
Code System Code Type Description
DRUG BANK
DB12650
Created by admin on Thu Jul 06 13:20:46 UTC 2023 , Edited by admin on Thu Jul 06 13:20:46 UTC 2023
PRIMARY
CAS
118313-25-0
Created by admin on Thu Jul 06 13:20:46 UTC 2023 , Edited by admin on Thu Jul 06 13:20:46 UTC 2023
PRIMARY
PUBCHEM
90274764
Created by admin on Thu Jul 06 13:20:46 UTC 2023 , Edited by admin on Thu Jul 06 13:20:46 UTC 2023
PRIMARY
FDA UNII
F2796O8AEN
Created by admin on Thu Jul 06 13:20:46 UTC 2023 , Edited by admin on Thu Jul 06 13:20:46 UTC 2023
PRIMARY
Related Record Type Details
Structure of SELEGILINE
NON-LABELED -> LABELED
Related Record Type Details
Structure of L-DEPRENYL-D2 C-11
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966