Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H35ClN2O2 |
| Molecular Weight | 419.0 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCCCNCCCC1=CC=C(Cl)C(=C1)C(=O)NCC23CC4CC(CC(C4)C2)C3
InChI
InChIKey=HSQAARMBHJCUOK-UHFFFAOYSA-N
InChI=1S/C24H35ClN2O2/c25-22-5-4-17(3-1-6-26-7-2-8-28)12-21(22)23(29)27-16-24-13-18-9-19(14-24)11-20(10-18)15-24/h4-5,12,18-20,26,28H,1-3,6-11,13-16H2,(H,27,29)
| Molecular Formula | C24H35ClN2O2 |
| Molecular Weight | 419.0 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
AZD9056 was developed as a selective inhibitor of the purinergic receptor P2X7, a key player in the generation and secretion of several proinflammatory cytokines. AZD 9056 participated is phase II clinical trials for osteoarthritis, inflammatory bowel disease, and chronic obstructive pulmonary disease but these studies were discontinued in 2009 because the drug failed to show significant efficacy in trials. In addition, in 2015 AZD 9056 was studied for the treatment of Crohn's disease (CD), although the drug has shown a beneficial risk profile the lack in the change of inflammatory biomarkers questions its anti-inflammatory potential.
Originator
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:00:13 GMT 2023
by
admin
on
Sat Dec 16 11:00:13 GMT 2023
|
| Record UNII |
F13K378W4L
|
| Record Status |
Validated (UNII)
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| Record Version |
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CHEMBL3545108
Created by
admin on Sat Dec 16 11:00:13 GMT 2023 , Edited by admin on Sat Dec 16 11:00:13 GMT 2023
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345304-65-6
Created by
admin on Sat Dec 16 11:00:13 GMT 2023 , Edited by admin on Sat Dec 16 11:00:13 GMT 2023
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F13K378W4L
Created by
admin on Sat Dec 16 11:00:13 GMT 2023 , Edited by admin on Sat Dec 16 11:00:13 GMT 2023
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100000175722
Created by
admin on Sat Dec 16 11:00:13 GMT 2023 , Edited by admin on Sat Dec 16 11:00:13 GMT 2023
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10161381
Created by
admin on Sat Dec 16 11:00:13 GMT 2023 , Edited by admin on Sat Dec 16 11:00:13 GMT 2023
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DB12594
Created by
admin on Sat Dec 16 11:00:13 GMT 2023 , Edited by admin on Sat Dec 16 11:00:13 GMT 2023
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ACTIVE MOIETY |
