Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H35ClN2O2 |
| Molecular Weight | 419.0 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCCCNCCCC1=CC=C(Cl)C(=C1)C(=O)NCC23CC4CC(CC(C4)C2)C3
InChI
InChIKey=HSQAARMBHJCUOK-UHFFFAOYSA-N
InChI=1S/C24H35ClN2O2/c25-22-5-4-17(3-1-6-26-7-2-8-28)12-21(22)23(29)27-16-24-13-18-9-19(14-24)11-20(10-18)15-24/h4-5,12,18-20,26,28H,1-3,6-11,13-16H2,(H,27,29)
| Molecular Formula | C24H35ClN2O2 |
| Molecular Weight | 419.0 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
AZD9056 was developed as a selective inhibitor of the purinergic receptor P2X7, a key player in the generation and secretion of several proinflammatory cytokines. AZD 9056 participated is phase II clinical trials for osteoarthritis, inflammatory bowel disease, and chronic obstructive pulmonary disease but these studies were discontinued in 2009 because the drug failed to show significant efficacy in trials. In addition, in 2015 AZD 9056 was studied for the treatment of Crohn's disease (CD), although the drug has shown a beneficial risk profile the lack in the change of inflammatory biomarkers questions its anti-inflammatory potential.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Targeting the P2X7 receptor in rheumatoid arthritis: biological rationale for P2X7 antagonism. | 2013-11-07 |
|
| Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine. | 2012-10 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:34:00 GMT 2025
by
admin
on
Mon Mar 31 23:34:00 GMT 2025
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| Record UNII |
F13K378W4L
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| Record Status |
Validated (UNII)
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| Record Version |
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CHEMBL3545108
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345304-65-6
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F13K378W4L
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100000175722
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10161381
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DB12594
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