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Details

Stereochemistry ACHIRAL
Molecular Formula C21H35N3
Molecular Weight 329.5227
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of BUCAINIDE

SMILES

CCCCCCN1CCN(CC1)C(=NCC(C)C)C2=CC=CC=C2

InChI

InChIKey=WRNQYBXJRPAGNS-UHFFFAOYSA-N
InChI=1S/C21H35N3/c1-4-5-6-10-13-23-14-16-24(17-15-23)21(22-18-19(2)3)20-11-8-7-9-12-20/h7-9,11-12,19H,4-6,10,13-18H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C21H35N3
Molecular Weight 329.5227
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Bucainide is a potent cardiac depressant and antiarrhythmic agent. The antiarrhythmic effect was demonstrated in the following animal models: mouse chloroform-induced ventricular arrhythmias, refractory period prolongation in guinea pig isolated atria, aconitine-induced atrial arrhythmias in the dog, ventricular arrhythmias following coronary artery ligation in the dog, and ouabain-induced ventricular tachyarrhythmias in the dog. The drug also possesses local anesthetic effects and is a weak central nervous system depressant. Studies with the radiolabeled drug in rats and dogs also demonstrated the drug's large volume of distribution, and its initial rapid disappearance from the blood. Tissue distribution studies in the rat after administration of the radiolabeled drug showed that bucainide is rapidly taken up by the tissues.

Approval Year

Substance Class Chemical
Created
by admin
on Fri Dec 15 16:13:33 UTC 2023
Edited
by admin
on Fri Dec 15 16:13:33 UTC 2023
Record UNII
F0D4M5RASG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BUCAINIDE
INN  
INN  
Official Name English
bucainide [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C47793
Created by admin on Fri Dec 15 16:13:33 UTC 2023 , Edited by admin on Fri Dec 15 16:13:33 UTC 2023
Code System Code Type Description
CAS
51481-62-0
Created by admin on Fri Dec 15 16:13:33 UTC 2023 , Edited by admin on Fri Dec 15 16:13:33 UTC 2023
PRIMARY
EPA CompTox
DTXSID20866201
Created by admin on Fri Dec 15 16:13:33 UTC 2023 , Edited by admin on Fri Dec 15 16:13:33 UTC 2023
PRIMARY
EVMPD
SUB05941MIG
Created by admin on Fri Dec 15 16:13:33 UTC 2023 , Edited by admin on Fri Dec 15 16:13:33 UTC 2023
PRIMARY
SMS_ID
100000085862
Created by admin on Fri Dec 15 16:13:33 UTC 2023 , Edited by admin on Fri Dec 15 16:13:33 UTC 2023
PRIMARY
INN
3969
Created by admin on Fri Dec 15 16:13:33 UTC 2023 , Edited by admin on Fri Dec 15 16:13:33 UTC 2023
PRIMARY
ChEMBL
CHEMBL2110888
Created by admin on Fri Dec 15 16:13:33 UTC 2023 , Edited by admin on Fri Dec 15 16:13:33 UTC 2023
PRIMARY
FDA UNII
F0D4M5RASG
Created by admin on Fri Dec 15 16:13:33 UTC 2023 , Edited by admin on Fri Dec 15 16:13:33 UTC 2023
PRIMARY
NCI_THESAURUS
C77978
Created by admin on Fri Dec 15 16:13:33 UTC 2023 , Edited by admin on Fri Dec 15 16:13:33 UTC 2023
PRIMARY
PUBCHEM
40026
Created by admin on Fri Dec 15 16:13:33 UTC 2023 , Edited by admin on Fri Dec 15 16:13:33 UTC 2023
PRIMARY
MESH
C019280
Created by admin on Fri Dec 15 16:13:33 UTC 2023 , Edited by admin on Fri Dec 15 16:13:33 UTC 2023
PRIMARY
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