Details
Stereochemistry | RACEMIC |
Molecular Formula | C19H24N2O4 |
Molecular Weight | 344.4049 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=C(OCC(O)CNCCOC2=CC=C(C=C2)C(N)=O)C=CC=C1
InChI
InChIKey=SKQDKFOTIPJUSV-UHFFFAOYSA-N
InChI=1S/C19H24N2O4/c1-14-4-2-3-5-18(14)25-13-16(22)12-21-10-11-24-17-8-6-15(7-9-17)19(20)23/h2-9,16,21-22H,10-13H2,1H3,(H2,20,23)
Molecular Formula | C19H24N2O4 |
Molecular Weight | 344.4049 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Tolamolol is a phenoxypropranolamine derivative that preferentially inhibits myocardial beta adrenoreceptors, possesses beta blocking potency equivalent to propranolol, has little or no direct cell membrane effect and lacks beta adrenergic stimulating action. Cardioselective beta adrenergic blockade with tolamolol was highly effective in controlling ventricular rate in supraventricular arrhythmias and reduced the frequency of ventricular ectopic beats in half of the small group of patients with this arrhythmia. It is particularly applicable in patients with obstructive pulmonary disease in whom cardiac beta adrenergic blockade is indicated. Hypotension is an important potential side effect. Tolamolol and propranolol are equal in anti-anginal efficacy but tolamolol has the advantage of being cardioselective. It is superior to practolol. Tolamolol had no effect on sperm motility.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Effect of beta-adrenoceptor blocking drugs, physostigmine, and atropine on the toxicity of doxepin in mice. | 1975 Aug |
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Double-blind comparison of tolamolol, propranolol, practolol, and placebo in the treatment of angina pectoris. | 1975 Mar 29 |
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Efficacy of cardioselective beta adrenergic blockade with intravenously administered tolamolol in the treatment of cardiac arrhythmias. | 1976 Aug |
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Antihypertensive action of drug combination: polythiazide, prazosin and tolamolol. | 1977 Feb |
|
Beta-adrenoceptor antagonists and human sperm motility. | 1990 Mar |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/804952
200 mg thrice daily for a month
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:32:13 GMT 2023
by
admin
on
Sat Dec 16 17:32:13 GMT 2023
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Record UNII |
F03W3WUW58
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29576
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DTXSID4046230
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38103-61-6
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C152678
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37910
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C100227
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3407
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Tolamolol
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100000077750
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253-783-8
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CHEMBL418192
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SUB11146MIG
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F03W3WUW58
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PRIMARY |
Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
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ACTIVE MOIETY |