CINEPAZET MALEATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H28N2O6.C4H4O4
Molecular Weight	508.5183
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C/C(O)=O.CCOC(=O)CN1CCN(CC1)C(=O)\C=C\C2=CC(OC)=C(OC)C(OC)=C2

InChI

InChIKey=URWISVHSKBDRKE-GVTSEVKNSA-N

InChI=1S/C20H28N2O6.C4H4O4/c1-5-28-19(24)14-21-8-10-22(11-9-21)18(23)7-6-15-12-16(25-2)20(27-4)17(13-15)26-3;5-3(6)1-2-4(7)8/h6-7,12-13H,5,8-11,14H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b7-6+;2-1-

HIDE SMILES / InChI

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Molecular Formula	C20H28N2O6
Molecular Weight	392.4461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://books.google.ru/books?id=_J2ti4EkYpkC&pg=PA1024&lpg=PA1024 | https://www.sciencedirect.com/science/article/pii/S0065774308612907

Cinepazet is an ethyl ester of cinepazic acid. It acts by inhibiting the influx of extracellular calcium into cells through the slow calcium channel in the cell membrane. In the 1970s cinepazet was marketed in France and Italy under tradename Vascoril for the treatment of angina.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Voltage-gated L-type calcium channel 92 Target ID: CHEMBL2095229 Sources: https://www.sciencedirect.com/science/article/pii/S0065774308612907	Blocker 537

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:18:09 GMT 2023` Edited by `admin` on `Fri Dec 15 15:18:09 GMT 2023`
Record UNII	F02NGQ0DSF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CINEPAZET MALEATE

Official Name

English

Cinepazet maleate [WHO-DD]

Common Name

English

CINEPAZET MALEATE [USAN]

Common Name

English

Ethyl 4-(3,4,5-trimethoxycinnamoyl)-1-piperazineacetate maleate (1:1)

Systematic Name

English

CINEPAZET MALEATE [MART.]

Common Name

English

CINEPAZET MALEATE [MI]

Common Name

English

1-PIPERAZINEACETIC ACID, 4-(1-OXO-3-(3,4,5-TRIMETHOXYPHENYL)-2-PROPENYL)-, ETHYL ESTER, (Z)-2-BUTENEDIOATE (1:1)

Common Name

English

Code System Code Type Description

MERCK INDEX

m1070