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Details

Stereochemistry ACHIRAL
Molecular Formula C18H18N2O
Molecular Weight 278.3483
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DEMEXIPTILINE

SMILES

CNCCON=C1C2=CC=CC=C2C=CC3=CC=CC=C13

InChI

InChIKey=SEDQWOMFMIJKCU-UHFFFAOYSA-N
InChI=1S/C18H18N2O/c1-19-12-13-21-20-18-16-8-4-2-6-14(16)10-11-15-7-3-5-9-17(15)18/h2-11,19H,12-13H2,1H3

HIDE SMILES / InChI
Molecular Formula C18H18N2O
Molecular Weight 278.3483
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Demexiptiline (Tinoran, Deparon) is a tricyclic antidepressant, noradrenergic drug. It is a norepinephrine reuptake inhibitor. Deparon was used in France for the treatment of depression.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
[Demexiptiline in the treatment of melancholic states (reflections after 3 years of use)].
1981 Nov
Anti-immobility activity of different antidepressant drugs using the tail suspension test in normal or reserpinized mice.
1993
Patents

Patents

CA2834262A1
2
EP2701684B1
2

Sample Use Guides

In Vivo Use Guide
Curator's Comment: LD50 in rats (mg/kg): 330 orally, 25 i.v. https://www.drugfuture.com/chemdata/demexiptiline.html
Treatment of depression: 50-75mg
Route of Administration: Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:10:39 UTC 2023
Edited
by admin
on Fri Dec 15 16:10:39 UTC 2023
Record UNII
EYX738UZ5P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DEMEXIPTILINE
INN   MI   WHO-DD  
INN  
Official Name English
demexiptiline [INN]
Common Name English
5H-DIBENZO(A,D)CYCLOHEPTEN-5-ONE O-(2-(METHYLAMINO)ETHYL)OXIME
Systematic Name English
DEMEXIPTILINE [MI]
Common Name English
Demexiptiline [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C265
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
Code System Code Type Description
WIKIPEDIA
Demexiptiline
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY
DRUG BANK
DB08998
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY
NCI_THESAURUS
C78013
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY
DRUG CENTRAL
804
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY
MESH
C033781
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY
INN
4834
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY
EVMPD
SUB06968MIG
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY
ChEMBL
CHEMBL2107576
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY
SMS_ID
100000083713
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY
MERCK INDEX
m1105
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY Merck Index
PUBCHEM
28876
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY
FDA UNII
EYX738UZ5P
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY
EPA CompTox
DTXSID40179441
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY
CAS
24701-51-7
Created by admin on Fri Dec 15 16:10:40 UTC 2023 , Edited by admin on Fri Dec 15 16:10:40 UTC 2023
PRIMARY
Related Record Type Details
Structure of DEMEXIPTILINE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of DEMEXIPTILINE
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