Spunoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 18:20:49 UTC 2023` Edited by `admin` on `Sat Dec 16 18:20:49 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	ALLOGENIC HUMAN
Source Materials State	LIVE
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Name	Peripheral blood mononuclear cells are obtained via apheresis from donors who are confirmed to be seropositive for the four target viruses (RSV, Influenza, PIV, hMPV)
Record UNII	EVQ94BW5G4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Spunoleucel

Official Name

English

Allogeneic Multi-Virus Specific T Lymphocytes Targeting Respiratory Syncytial Virus (RSV), Influenza, Parainfluenza Virus (PIV), and Human Metapneumovirus (hMPV)

Common Name

English

ALVR106 is a polyclonal (CD4+ and CD8+) virus-specific T cell product containing cells that are reactive against four viruses (RSV, Influenza, PIV, and hMPV). The cells are derived from peripheral blood mononuclear cells (PBMCs) from donors seropositive

Common Name

English

ALVR106

Code

English

ALVR106 is comprised of both CD8+ and CD4+ virus-specific T cells capable of recognizing actively replicating virus-infected cells, proliferating in response to antigenic stimulation and mediating antiviral effects including the production of cytokines a

Common Name

English

ALVR106 is a novel virus-specific cell-based therapy to treat four respiratory viral infections that are a serious cause of morbidity and mortality in immunocompromised patients. ALVR106 is under development to treat four respiratory viral infections (re

Common Name

English

SPUNOLEUCEL [USAN]

Common Name

English

ALV-106

Code

English

Code System Code Type Description

USAN

KL-230

Created by admin on Sat Dec 16 18:20:49 UTC 2023 , Edited by admin on Sat Dec 16 18:20:49 UTC 2023

PRIMARY

INN

12976

Created by admin on Sat Dec 16 18:20:49 UTC 2023 , Edited by admin on Sat Dec 16 18:20:49 UTC 2023

PRIMARY

FDA UNII

EVQ94BW5G4

Created by admin on Sat Dec 16 18:20:49 UTC 2023 , Edited by admin on Sat Dec 16 18:20:49 UTC 2023

PRIMARY

Related Record Type Details


					EVQ94BW5G4

Spunoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Fragment Name	Fragment ID
CULTURE	EXPANSION	INTERLEUKIN-7 HUMAN RECOMBINANT	418XB47Y71
CULTURE	EXPANSION	IL-4 HUMAN	4I7AHS3FPJ
CULTURE	other	UNSPECIFIED SUBSTANCE	e06f5a80