SC-41930

Details

Stereochemistry	RACEMIC
Molecular Formula	C28H36O7
Molecular Weight	484.5812
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC1=C(OCCCOC2=C(CCC)C3=C(CCC(O3)C(O)=O)C=C2)C=CC(C(C)=O)=C1OC

InChI

InChIKey=ZVVCSBSDFGYRCB-UHFFFAOYSA-N

InChI=1S/C28H36O7/c1-5-8-21-23(13-10-19-11-14-25(28(30)31)35-26(19)21)33-16-7-17-34-24-15-12-20(18(3)29)27(32-4)22(24)9-6-2/h10,12-13,15,25H,5-9,11,14,16-17H2,1-4H3,(H,30,31)

HIDE SMILES / InChI

Molecular Formula	C28H36O7
Molecular Weight	484.5812
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1309871 | https://www.ncbi.nlm.nih.gov/pubmed/8638901 | https://www.ncbi.nlm.nih.gov/pubmed/2561214

SC-41930 has been shown to be a specific LTB4 receptor antagonist both in vitro and in vivo. SC-41930 can produce significant anti-inflammatory effects. The anti-inflammatory activity of SC-41930 could be attributed to postreceptor inhibition of inflammatory mediator production by human neutrophil and other cells in addition to antagonism of human neutrophil LTB4 receptors.

Approval Year

PubMed

Title	Date	PubMed
Blockade of human neutrophil activation by 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]propoxy]phenoxy]benzoic acid (LY293111), a novel leukotriene B4 receptor antagonist.	1995-05-26	7786309
Phorbol ester-induced dermal inflammation in mice: evaluation of inhibitors of 5-lipoxygenase and antagonists of leukotriene B4 receptor.	1994-09	7812673
In vivo characterization of zymosan-induced mouse peritoneal inflammation.	1994-06	8014878

Patents

Sample Use Guides

In Vivo Use Guide

1 mg/kg pretriatment (-30 min) before 6-trans-LTB4 injection

Route of Administration: Oral

In Vitro Use Guide

SC-41930 was evaluated for effects on human neutrophil chemotaxis and degranulation. At concentrations up to 100 uM, SC-41930 alone exhibited no effect on neutrophil migration, but dose-dependently inhibited neutrophil chemotaxis induced by leukotriene B4 (LTB4) in a modified Boyden chamber. Concentrations of SC-41930 from 0.3 uM to 3 uM competitively inhibited LTB4-induced chemotaxis with a pA2 value of 6.35.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:11:32 GMT 2025` Edited by `admin` on `Mon Mar 31 18:11:32 GMT 2025`
Record UNII	EVH7O0422T
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SC-41930

Common Name

English

CGS-24115

Preferred Name

English

(±)-7-(3-(4-ACETYL-3-METHOXY-2-PROPYLPHENOXY)PROPOXY)-3,4-DIHYDRO-8-PROPYL-2H-1-BENZOPYRAN-2-CARBOXYLIC ACID

Systematic Name

English

2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 7-(3-(4-ACETYL-3-METHOXY-2-PROPYLPHENOXY)PROPOXY)-3,4-DIHYDRO-8-PROPYL-

Common Name

English

7-(3-(4-ACETYL-3-METHOXY-2-PROPYL-PHENOXY)PROPOXYL-3,4-DIHYDRO-8-PROPYL-2H-1-BENZOPYRAN-2-CARBOXYLIC ACID

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

164102