Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H25N3O2 |
| Molecular Weight | 375.4635 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1CC2=CC3=C(ON=C3CCC4CCN(CC5=CC=CC=C5)CC4)C=C2N1
InChI
InChIKey=MTCMTKNMZCPKLX-UHFFFAOYSA-N
InChI=1S/C23H25N3O2/c27-23-13-18-12-19-20(25-28-22(19)14-21(18)24-23)7-6-16-8-10-26(11-9-16)15-17-4-2-1-3-5-17/h1-5,12,14,16H,6-11,13,15H2,(H,24,27)
| Molecular Formula | C23H25N3O2 |
| Molecular Weight | 375.4635 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Icopezil (previously known as CP-118,954) was developed as a selective acetylcholinesterase inhibitor for the treatment of cognitive disorders. Phase II trials of icopezil were underway in Japan and in the USA for the treatment of patients with Alzheimer's disease. However, Pfizer has discontinued these studies.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Synthesis and evaluation of 5,7-dihydro-3-[2-[1-(4-[18F]-fluorobenzyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one for in vivo mapping of acetylcholinesterase. | 2004 Jun |
|
| Synthesis and evaluation of 2-[18F]fluoro-CP-118,954 for the in vivo mapping of acetylcholinesterase. | 2005 Feb |
|
| Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase. | 2007 Jul |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:00:30 GMT 2023
by
admin
on
Fri Dec 15 19:00:30 GMT 2023
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| Record UNII |
ERZ60E6B7C
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| Record Status |
Validated (UNII)
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C47792
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| Related Record | Type | Details | ||
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DERIVATIVE -> PARENT |
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SALT/SOLVATE -> PARENT |
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TARGET -> INHIBITOR |
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ACTIVE MOIETY |
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