CERLAPIRDINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H23N3O3S
Molecular Weight	409.501
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CERLAPIRDINE

Structure Search

SMILES

CN(C)CCCOC1=CC2=C(NN=C2S(=O)(=O)C3=CC=CC4=C3C=CC=C4)C=C1

InChI

InChIKey=NXQGEDVQXVTCDA-UHFFFAOYSA-N

InChI=1S/C22H23N3O3S/c1-25(2)13-6-14-28-17-11-12-20-19(15-17)22(24-23-20)29(26,27)21-10-5-8-16-7-3-4-9-18(16)21/h3-5,7-12,15H,6,13-14H2,1-2H3,(H,23,24)

HIDE SMILES / InChI

Molecular Formula	C22H23N3O3S
Molecular Weight	409.501
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25217486 | https://www.ncbi.nlm.nih.gov/pubmed/24900216 | https://www.ncbi.nlm.nih.gov/pubmed/21330210 | https://www.ncbi.nlm.nih.gov/pubmed/22029285

Cerlapirdine is a selective and potent full antagonist of the serotonin 6 (5-HT6) receptor that has been investigated by Wyeth and Pfizer for the treatment of Alzheimer Disease.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed

Patents

Patents

Sample Use Guides

In Vivo Use Guide

5-mg/day

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:16:47 GMT 2023` Edited by `admin` on `Fri Dec 15 17:16:47 GMT 2023`
Record UNII	EK40PJ0V49
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CERLAPIRDINE

Official Name

English

WAY-262,531

Code

English

SAM-531

Code

English

SAM-531 FREE BASE

Code

English

Cerlapirdine [WHO-DD]

Common Name

English

CERLAPIRDINE [USAN]

Common Name

English

WAY-262531

Code

English

PF-05212365

Code

English

N,N-DIMETHYL-3-((3-(1-NAPHTHYLSULFONYL)-1H-INDAZOL-5-YL)OXY)PROPAN-1-AMINE

Systematic Name

English

N,N-DIMETHYL-3-((3-((NAPHTHALEN-1-YL)SULFONYL)-1H-INDAZOL-5-YL)OXY)PROPAN-1-AMINE

Systematic Name

English

cerlapirdine [INN]

Common Name

English

1-PROPANAMINE, N,N-DIMETHYL-3-((3-(1-NAPHTHALENYLSULFONYL)-1H-INDAZOL-5-YL)OXY)-

Systematic Name

English

Code System Code Type Description

FDA UNII

EK40PJ0V49

Created by admin on Fri Dec 15 17:16:47 GMT 2023 , Edited by admin on Fri Dec 15 17:16:47 GMT 2023

PRIMARY

SMS_ID

100000164091

Created by admin on Fri Dec 15 17:16:47 GMT 2023 , Edited by admin on Fri Dec 15 17:16:47 GMT 2023

PRIMARY

WIKIPEDIA

Cerlapirdine

Created by admin on Fri Dec 15 17:16:47 GMT 2023 , Edited by admin on Fri Dec 15 17:16:47 GMT 2023

PRIMARY

INN

9553

Created by admin on Fri Dec 15 17:16:47 GMT 2023 , Edited by admin on Fri Dec 15 17:16:47 GMT 2023

PRIMARY

NCI_THESAURUS

C169839

Created by admin on Fri Dec 15 17:16:47 GMT 2023 , Edited by admin on Fri Dec 15 17:16:47 GMT 2023

PRIMARY

CAS

925448-93-7

Created by admin on Fri Dec 15 17:16:47 GMT 2023 , Edited by admin on Fri Dec 15 17:16:47 GMT 2023

PRIMARY

ChEMBL

CHEMBL2103880

Created by admin on Fri Dec 15 17:16:47 GMT 2023 , Edited by admin on Fri Dec 15 17:16:47 GMT 2023

PRIMARY

USAN

XX-143

Created by admin on Fri Dec 15 17:16:47 GMT 2023 , Edited by admin on Fri Dec 15 17:16:47 GMT 2023

PRIMARY

EPA CompTox

DTXSID201137232

Created by admin on Fri Dec 15 17:16:47 GMT 2023 , Edited by admin on Fri Dec 15 17:16:47 GMT 2023

PRIMARY

EVMPD

SUB178433

Created by admin on Fri Dec 15 17:16:47 GMT 2023 , Edited by admin on Fri Dec 15 17:16:47 GMT 2023

PRIMARY

PUBCHEM

16071605

Created by admin on Fri Dec 15 17:16:47 GMT 2023 , Edited by admin on Fri Dec 15 17:16:47 GMT 2023

PRIMARY

DRUG BANK

DB12229

Created by admin on Fri Dec 15 17:16:47 GMT 2023 , Edited by admin on Fri Dec 15 17:16:47 GMT 2023

PRIMARY

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					EK40PJ0V49

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Interaction Type:

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EXCRETED UNCHANGED

Interaction Type:

AMOUNT EXCRETED

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SALT/SOLVATE -> PARENT


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METABOLIC ENZYME -> SUBSTRATE


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5-HYDROXYTRYPTAMINE RECEPTOR 6

TARGET->ANTAGONIST

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N,N-DIMETHYL-3-((3-(1-NAPHTHYLSULFONYL)-1H-INDAZOL-5-YL)OXY)PROPAN-1-AMINE OXIDE

METABOLITE -> PARENT

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METABOLITE -> PARENT

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DESMETHYLCERLAPERIDINE

METABOLITE -> PARENT

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Amount:

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ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION SINGLE DOSE

Biological Half-life	PHARMACOKINETIC				SINGLE DOSE ORAL ADMINISTRATION