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Details

Stereochemistry ACHIRAL
Molecular Formula C22H23N3O3S
Molecular Weight 409.501
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CERLAPIRDINE

SMILES

CN(C)CCCOC1=CC2=C(NN=C2S(=O)(=O)C3=CC=CC4=CC=CC=C34)C=C1

InChI

InChIKey=NXQGEDVQXVTCDA-UHFFFAOYSA-N
InChI=1S/C22H23N3O3S/c1-25(2)13-6-14-28-17-11-12-20-19(15-17)22(24-23-20)29(26,27)21-10-5-8-16-7-3-4-9-18(16)21/h3-5,7-12,15H,6,13-14H2,1-2H3,(H,23,24)

HIDE SMILES / InChI

Molecular Formula C22H23N3O3S
Molecular Weight 409.501
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Cerlapirdine is a selective and potent full antagonist of the serotonin 6 (5-HT6) receptor that has been investigated by Wyeth and Pfizer for the treatment of Alzheimer Disease.

Approval Year

PubMed

PubMed

TitleDatePubMed
Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.
2011 Dec 8
5-HT(6) receptor and cognition.
2011 Feb
Patents

Sample Use Guides

In Vivo Use Guide
5-mg/day
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Mon Oct 21 20:41:40 UTC 2019
Edited
by admin
on Mon Oct 21 20:41:40 UTC 2019
Record UNII
EK40PJ0V49
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CERLAPIRDINE
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
WAY-262,531
Code English
SAM-531
Code English
SAM-531 FREE BASE
Code English
CERLAPIRDINE [WHO-DD]
Common Name English
CERLAPIRDINE [USAN]
Common Name English
WAY-262531
Code English
PF-05212365
Code English
N,N-DIMETHYL-3-((3-(1-NAPHTHYLSULFONYL)-1H-INDAZOL-5-YL)OXY)PROPAN-1-AMINE
Systematic Name English
N,N-DIMETHYL-3-((3-((NAPHTHALEN-1-YL)SULFONYL)-1H-INDAZOL-5-YL)OXY)PROPAN-1-AMINE
Systematic Name English
CERLAPIRDINE [INN]
Common Name English
1-PROPANAMINE, N,N-DIMETHYL-3-((3-(1-NAPHTHALENYLSULFONYL)-1H-INDAZOL-5-YL)OXY)-
Systematic Name English
Code System Code Type Description
INN
9553
Created by admin on Mon Oct 21 20:41:40 UTC 2019 , Edited by admin on Mon Oct 21 20:41:40 UTC 2019
PRIMARY
CAS
925448-93-7
Created by admin on Mon Oct 21 20:41:40 UTC 2019 , Edited by admin on Mon Oct 21 20:41:40 UTC 2019
PRIMARY
ChEMBL
CHEMBL2103880
Created by admin on Mon Oct 21 20:41:40 UTC 2019 , Edited by admin on Mon Oct 21 20:41:40 UTC 2019
PRIMARY
EVMPD
SUB178433
Created by admin on Mon Oct 21 20:41:40 UTC 2019 , Edited by admin on Mon Oct 21 20:41:40 UTC 2019
PRIMARY
PUBCHEM
16071605
Created by admin on Mon Oct 21 20:41:40 UTC 2019 , Edited by admin on Mon Oct 21 20:41:40 UTC 2019
PRIMARY
Related Record Type Details
EXCRETED UNCHANGED
AMOUNT EXCRETED
URINE
EXCRETED UNCHANGED
AMOUNT EXCRETED
FECAL
SALT/SOLVATE -> PARENT
METABOLIC ENZYME -> SUBSTRATE
MAJOR
METABOLIC ENZYME -> SUBSTRATE
TARGET->ANTAGONIST
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC ORAL ADMINISTRATION

SINGLE DOSE

Biological Half-life PHARMACOKINETIC SINGLE DOSE

ORAL ADMINISTRATION