Rapcabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 16:33:11 UTC 2023` Edited by `admin` on `Sat Dec 16 16:33:11 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD CELL
Fraction Material Type	CELL
Fraction Name	T-CELLS
Record UNII	EJG3KK52YP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Rapcabtagene Autoleucel

Official Name

English

Autologous T cells obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, nonreplicating lentiviral vector, encoding a T cell chimeric antigen receptor targeting CD19. The expressed transgene comprises a C

Chemical Description

English

YTB-323

Code

English

ANTI-CD19 CAR-T CELL THERAPY YTB323

Common Name

English

RAPCABTAGENE AUTOLEUCEL [USAN]

Common Name

English

YTB323

Code

English

Code System Code Type Description

USAN

LM-110

Created by admin on Sat Dec 16 16:33:11 UTC 2023 , Edited by admin on Sat Dec 16 16:33:11 UTC 2023

PRIMARY

INN

11974

Created by admin on Sat Dec 16 16:33:11 UTC 2023 , Edited by admin on Sat Dec 16 16:33:11 UTC 2023

PRIMARY

FDA UNII

EJG3KK52YP

Created by admin on Sat Dec 16 16:33:11 UTC 2023 , Edited by admin on Sat Dec 16 16:33:11 UTC 2023

PRIMARY

Related Record Type Details


					TYR224OK86

CD19 POSITIVE CELLS

TARGET->CYTOTOXIC T-CELL

Amount:


					IYZ9TI08W3

B-LYMPHOCYTE ANTIGEN CD19

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					EJG3KK52YP

Rapcabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
TICELL ACTIVATION	EXPANSION	BIOLOGICAL	T CELL TRANSACT, HUMAN	YG578HEY4V
T-CELL SELECTION	TARGETED ANTIGEN	IMMUNOLOGICAL	UNSPECIFIED SUBSTANCE	5c1f06ef
T-CELL SELECTION	TARGETED ANTIGENS	IMMUNOLOGICAL	UNSPECIFIED SUBSTANCE	2399a508
TRANSFECTION FOLLOWED BY EXPANSION AND RELEASE FROM MAGNETIC BEADS	RECEPTOR EXPRESSION	RETROVIRAL TRANSFECTION	UNSPECIFIED SUBSTANCE	d5204918
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN 2, RECOMBINANT NON-GLYCOSYLATED	72WT6YGC0U

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					TISAGENLECLEUCEL CAR-T RECEPTOR	E1A4B5F3ZQ

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC				TISSUE MEASURED PHARMACOKINETIC
CD4/CD8 RATIO	BIOLOGICAL