RO-41-3290

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H21ClN2O3
Molecular Weight	420.888
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@H]1CCN(C1)C(=O)C2=C3N(CCC4=C3C=C(Cl)C=C4)C(=O)C(=C2)C5=CC=CC=C5

InChI

InChIKey=ASOBQUGZPVVXJT-SFHVURJKSA-N

InChI=1S/C24H21ClN2O3/c25-17-7-6-16-8-11-27-22(19(16)12-17)21(23(29)26-10-9-18(28)14-26)13-20(24(27)30)15-4-2-1-3-5-15/h1-7,12-13,18,28H,8-11,14H2/t18-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C24H21ClN2O3
Molecular Weight	420.888
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 02:53:18 GMT 2023` Edited by `admin` on `Sat Dec 16 02:53:18 GMT 2023`
Record UNII	EIR1Q66583
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RO-41-3290

Common Name

English

RO41-3290

Code

English

10-CHLORO-1-((3S)-3-HYDROXYPYRROLIDINE-1-CARBONYL)-3-PHENYL-6,7-DIHYDROBENZO(A)QUINOLIZIN-4-ONE

Systematic Name

English

3-PYRROLIDINOL, 1-((10-CHLORO-6,7-DIHYDRO-4-OXO-3-PHENYL-4H-BENZO(A)QUINOLIZIN-1-YL)CARBONYL)-, (3S)-

Systematic Name

English

3-PYRROLIDINOL, 1-((10-CHLORO-6,7-DIHYDRO-4-OXO-3-PHENYL-4H-BENZO(A)QUINOLIZIN-1-YL)CARBONYL)-, (S)-

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

LIREQUINIL

Created by admin on Sat Dec 16 02:53:18 GMT 2023 , Edited by admin on Sat Dec 16 02:53:18 GMT 2023

PRIMARY

CAS

143943-72-0

Created by admin on Sat Dec 16 02:53:18 GMT 2023 , Edited by admin on Sat Dec 16 02:53:18 GMT 2023

PRIMARY

FDA UNII

EIR1Q66583

Created by admin on Sat Dec 16 02:53:18 GMT 2023 , Edited by admin on Sat Dec 16 02:53:18 GMT 2023

PRIMARY

PUBCHEM

14770131

Created by admin on Sat Dec 16 02:53:18 GMT 2023 , Edited by admin on Sat Dec 16 02:53:18 GMT 2023

PRIMARY

Related Record Type Details


					EIR1Q66583

RO-41-3290

ACTIVE MOIETY

Comments:

Ro 41-3290 induced moderate, dose-independent effects, which were most pronounced at 4 h after intake. Long-term memory, as assessed by a word learning and recall test, was not clearly affected by any drug. The pharmacokinetics of Ro 41-3290 were dose proportional with an elimination half-life of approximately 8 h. The relatively slow absorption of Ro 41-3290 (t(max) approximately 2.5 h) and the concentration-effect time delay do not make it a good candidate to replace its parent compound Ro 41-3696 as an investigational hypnotic.